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Oxalosis
Derik L. Davis, MD; B. J. Manaster, MD, PhD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Definitions

              • Calcium oxalate crystal deposition in organ systems, including bone

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • PET Findings

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Gross Pathologic & Surgical Features

                          CLINICAL ISSUES

                          • Demographics

                            • Natural History & Prognosis

                              • Treatment

                                • Clinical Signs

                                  • Diagnosis

                                    Selected References

                                    1. Choi EJ et al: Bone oxaloma-a localized manifestation of bone oxalosis. Skeletal Radiol. 49(4):651-5, 2020
                                    2. Somme F et al: Evaluation of oxalate osteopathy secondary to hyperoxaluria with 18F-FDG PET/CT and 99mTc-HMDP bone scan. Clin Nucl Med. 44(2):123-4, 2019
                                    3. Strauss SB et al: Primary hyperoxaluria: spectrum of clinical and imaging findings. Pediatr Radiol. 47(1):96-103, 2017
                                    4. Assimos DG: Re: Nephrocalcinosis is a risk factor for kidney failure in primary hyperoxaluria. J Urol. 193(3):900-1, 2015
                                    5. Assimos DG: Re: pharmacologic rescue of an enzyme-trafficking defect in primary hyperoxaluria 1. J Urol. 193(3):1062, 2015
                                    6. Bacchetta J et al: Bone impairment in primary hyperoxaluria: a review. Pediatr Nephrol. 31(1):1-6, 2015
                                    7. Coulter-Mackie MB: SNP variants in RET and PAX2 and their possible contribution to the primary hyperoxaluria type 1 phenotype. Biochem Genet. 53(1-3):23-8, 2015
                                    8. Nazzal L et al: Enteric hyperoxaluria: an important cause of end-stage kidney disease. Nephrol Dial Transplant. 31(3):375-82, 2015
                                    9. Sasaki K et al: Two-step transplantation for primary hyperoxaluria: a winning strategy to prevent progression of systemic oxalosis in early onset renal insufficiency cases. Pediatr Transplant. 19(1):E1-6, 2015
                                    10. Orazi C et al: Oxalosis in primary hyperoxaluria in infancy : report of a case in a 3-month-old baby. Follow-up for 3 years and review of literature. Skeletal Radiol. 38(4):387-91, 2009
                                    11. Vichi GF et al: Progression of bone lesions in a child with primary hyperoxaluria type 1: evaluation by roentgenology and MRI. Pediatr Radiol. 25 Suppl 1:S102-4, 1995
                                    12. Solmos GR et al: Rapid reversal of bone scan abnormalities in a patient with type 1 primary hyperoxaluria and oxalosis. Clin Nucl Med. 19(9):769-72, 1994
                                    13. Knight RQ et al: Oxalosis: cause of degenerative spinal stenosis. A case report and review of the literature. Orthopedics. 11(6):955-8, 1988
                                    Related Anatomy
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                                    Related Differential Diagnoses
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                                    References
                                    Tables

                                    Tables

                                    KEY FACTS

                                    • Terminology

                                      • Imaging

                                        • Top Differential Diagnoses

                                          • Pathology

                                            • Clinical Issues

                                              TERMINOLOGY

                                              • Definitions

                                                • Calcium oxalate crystal deposition in organ systems, including bone

                                              IMAGING

                                              • General Features

                                                • Radiographic Findings

                                                  • CT Findings

                                                    • PET Findings

                                                      DIFFERENTIAL DIAGNOSIS

                                                        PATHOLOGY

                                                        • General Features

                                                          • Gross Pathologic & Surgical Features

                                                            CLINICAL ISSUES

                                                            • Demographics

                                                              • Natural History & Prognosis

                                                                • Treatment

                                                                  • Clinical Signs

                                                                    • Diagnosis

                                                                      Selected References

                                                                      1. Choi EJ et al: Bone oxaloma-a localized manifestation of bone oxalosis. Skeletal Radiol. 49(4):651-5, 2020
                                                                      2. Somme F et al: Evaluation of oxalate osteopathy secondary to hyperoxaluria with 18F-FDG PET/CT and 99mTc-HMDP bone scan. Clin Nucl Med. 44(2):123-4, 2019
                                                                      3. Strauss SB et al: Primary hyperoxaluria: spectrum of clinical and imaging findings. Pediatr Radiol. 47(1):96-103, 2017
                                                                      4. Assimos DG: Re: Nephrocalcinosis is a risk factor for kidney failure in primary hyperoxaluria. J Urol. 193(3):900-1, 2015
                                                                      5. Assimos DG: Re: pharmacologic rescue of an enzyme-trafficking defect in primary hyperoxaluria 1. J Urol. 193(3):1062, 2015
                                                                      6. Bacchetta J et al: Bone impairment in primary hyperoxaluria: a review. Pediatr Nephrol. 31(1):1-6, 2015
                                                                      7. Coulter-Mackie MB: SNP variants in RET and PAX2 and their possible contribution to the primary hyperoxaluria type 1 phenotype. Biochem Genet. 53(1-3):23-8, 2015
                                                                      8. Nazzal L et al: Enteric hyperoxaluria: an important cause of end-stage kidney disease. Nephrol Dial Transplant. 31(3):375-82, 2015
                                                                      9. Sasaki K et al: Two-step transplantation for primary hyperoxaluria: a winning strategy to prevent progression of systemic oxalosis in early onset renal insufficiency cases. Pediatr Transplant. 19(1):E1-6, 2015
                                                                      10. Orazi C et al: Oxalosis in primary hyperoxaluria in infancy : report of a case in a 3-month-old baby. Follow-up for 3 years and review of literature. Skeletal Radiol. 38(4):387-91, 2009
                                                                      11. Vichi GF et al: Progression of bone lesions in a child with primary hyperoxaluria type 1: evaluation by roentgenology and MRI. Pediatr Radiol. 25 Suppl 1:S102-4, 1995
                                                                      12. Solmos GR et al: Rapid reversal of bone scan abnormalities in a patient with type 1 primary hyperoxaluria and oxalosis. Clin Nucl Med. 19(9):769-72, 1994
                                                                      13. Knight RQ et al: Oxalosis: cause of degenerative spinal stenosis. A case report and review of the literature. Orthopedics. 11(6):955-8, 1988