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Paget Disease
Kevin R. Moore, MD; Jeffrey S. Ross, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Paget disease (PD), Paget disease of bone (PDB)
              • Synonyms

                • Osteitis deformans
              • Definitions

                • Chronic metabolic disorder of abnormal bone remodeling in adult skeleton

              IMAGING

              • General Features

                • Radiographic Findings

                  • CT Findings

                    • MR Findings

                      • Nuclear Medicine Findings

                        • Imaging Recommendations

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              • Staging, Grading, & Classification

                                • Gross Pathologic & Surgical Features

                                  • Microscopic Features

                                    CLINICAL ISSUES

                                    • Presentation

                                      • Demographics

                                        • Natural History & Prognosis

                                          • Treatment

                                            DIAGNOSTIC CHECKLIST

                                            • Image Interpretation Pearls

                                              Selected References

                                              1. Rolvien T et al: Skeletal dissemination in Paget's disease of the spine. Eur Spine J. 27(Suppl 3):453-7, 2018
                                              2. Senthil V et al: Monostotic Paget disease of the lumbar vertebrae: a pathological mimicker. Neurospine. 15(2):182-6, 2018
                                              3. Winn N et al: Imaging of Paget's disease of bone. Wien Med Wochenschr. 167(1-2):9-17, 2017
                                              4. Jorge-Mora A et al: Surgical treatment in spine Paget's disease: a systematic review. Eur J Orthop Surg Traumatol. 26(1):27-30, 2016
                                              5. Morales H: MR imaging findings of Paget's disease of the spine. Clin Neuroradiol. 25(3):225-32, 2015
                                              6. Ralston SH: Clinical practice. Paget's disease of bone. N Engl J Med. 368(7):644-50, 2013
                                              7. Theodorou DJ et al: Imaging of Paget disease of bone and its musculoskeletal complications: review. AJR Am J Roentgenol. 196(6 Suppl):S64-75, 2011
                                              8. Varenna M et al: Demographic and clinical features related to a symptomatic onset of Paget's disease of bone. J Rheumatol. 37(1):155-60, 2010
                                              9. Merchant A et al: Somatic mutations in SQSTM1 detected in affected tissues from patients with sporadic Paget's disease of bone. J Bone Miner Res. 24(3):484-94, 2009
                                              10. Colina M et al: Paget's disease of bone: a review. Rheumatol Int. 28(11):1069-75, 2008
                                              11. Kimonis VE et al: Clinical studies in familial VCP myopathy associated with Paget disease of bone and frontotemporal dementia. Am J Med Genet A. 146A(6):745-57, 2008
                                              12. Rodallec MH et al: Diagnostic imaging of solitary tumors of the spine: what to do and say. Radiographics. 28(4):1019-41, 2008
                                              13. Tessitore E et al: Cervical Paget disease of bone with spinal cord compression due to atlanto-axial instability: a case report and review of the literature. Spine (Phila Pa 1976). 33(3):E85-9, 2008
                                              14. Oikonomou A et al: Paget disease of the spine manifested by thoracic and lumbar epidural lipomatosis: magnetic resonance imaging findings. Spine (Phila Pa 1976). 32(25):E789-92, 2007
                                              15. Hansen MF et al: Osteosarcoma in Paget's disease of bone. J Bone Miner Res. 21 Suppl 2:P58-63, 2006
                                              16. Saifuddin A et al: Paget's disease of the spine: unusual features and complications. Clin Radiol. 58(2):102-11, 2003
                                              17. Spieth ME et al: Positron emission tomography and Paget disease: hot is not necessarily malignant. Clin Nucl Med. 28(9):773-4, 2003
                                              18. Smith SE et al: From the archives of the AFIP. Radiologic spectrum of Paget disease of bone and its complications with pathologic correlation. Radiographics. 22(5):1191-216, 2002
                                              19. Whitehouse RW: Paget's disease of bone. Semin Musculoskelet Radiol. 6(4):313-22, 2002
                                              20. Hadjipavlou AG et al: Paget's disease of the spine and its management. Eur Spine J. 10(5):370-84, 2001
                                              21. Vande Berg BC et al: Magnetic resonance appearance of uncomplicated Paget's disease of bone. Semin Musculoskelet Radiol. 5(1):69-77, 2001
                                              22. Poncelet A: The neurologic complications of Paget's disease. J Bone Miner Res. 14 Suppl 2:88-91, 1999
                                              23. Boutin RD et al: Complications in Paget disease at MR imaging. Radiology. 209(3):641-51, 1998
                                              24. Cook GJ et al: Fluorine-18-FDG PET in Paget's disease of bone. J Nucl Med. 38(9):1495-7, 1997
                                              25. Klein RM et al: Diagnostic procedures for Paget's disease. Radiologic, pathologic, and laboratory testing. Endocrinol Metab Clin North Am. 24(2):437-50, 1995
                                              26. Mirra JM et al: Paget's disease of bone: review with emphasis on radiologic features, Part I. Skeletal Radiol. 24(3):163-71, 1995
                                              27. Mirra JM et al: Paget's disease of bone: review with emphasis on radiologic features, Part II. Skeletal Radiol. 24(3):173-84, 1995
                                              28. Hadjipavlou A et al: Malignant transformation in Paget disease of bone. Cancer. 70(12):2802-8, 1992
                                              29. Ryan MD et al: Spinal manifestations of Paget's disease. Aust N Z J Surg. 62(1):33-8, 1992
                                              30. Roberts MC et al: Paget disease: MR imaging findings. Radiology. 173(2):341-5, 1989
                                              31. Vellenga CJ et al: Bone scintigraphy and radiology in Paget's disease of bone: a review. Am J Physiol Imaging. 3(3):154-68, 1988
                                              32. Frame B et al: Paget disease: a review of current knowledge. Radiology. 141(1):21-4, 1981
                                              Related Anatomy
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                                              Related Differential Diagnoses
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                                              References
                                              Tables

                                              Tables

                                              KEY FACTS

                                              • Terminology

                                                • Imaging

                                                  • Top Differential Diagnoses

                                                    • Pathology

                                                      • Clinical Issues

                                                        • Diagnostic Checklist

                                                          TERMINOLOGY

                                                          • Abbreviations

                                                            • Paget disease (PD), Paget disease of bone (PDB)
                                                          • Synonyms

                                                            • Osteitis deformans
                                                          • Definitions

                                                            • Chronic metabolic disorder of abnormal bone remodeling in adult skeleton

                                                          IMAGING

                                                          • General Features

                                                            • Radiographic Findings

                                                              • CT Findings

                                                                • MR Findings

                                                                  • Nuclear Medicine Findings

                                                                    • Imaging Recommendations

                                                                      DIFFERENTIAL DIAGNOSIS

                                                                        PATHOLOGY

                                                                        • General Features

                                                                          • Staging, Grading, & Classification

                                                                            • Gross Pathologic & Surgical Features

                                                                              • Microscopic Features

                                                                                CLINICAL ISSUES

                                                                                • Presentation

                                                                                  • Demographics

                                                                                    • Natural History & Prognosis

                                                                                      • Treatment

                                                                                        DIAGNOSTIC CHECKLIST

                                                                                        • Image Interpretation Pearls

                                                                                          Selected References

                                                                                          1. Rolvien T et al: Skeletal dissemination in Paget's disease of the spine. Eur Spine J. 27(Suppl 3):453-7, 2018
                                                                                          2. Senthil V et al: Monostotic Paget disease of the lumbar vertebrae: a pathological mimicker. Neurospine. 15(2):182-6, 2018
                                                                                          3. Winn N et al: Imaging of Paget's disease of bone. Wien Med Wochenschr. 167(1-2):9-17, 2017
                                                                                          4. Jorge-Mora A et al: Surgical treatment in spine Paget's disease: a systematic review. Eur J Orthop Surg Traumatol. 26(1):27-30, 2016
                                                                                          5. Morales H: MR imaging findings of Paget's disease of the spine. Clin Neuroradiol. 25(3):225-32, 2015
                                                                                          6. Ralston SH: Clinical practice. Paget's disease of bone. N Engl J Med. 368(7):644-50, 2013
                                                                                          7. Theodorou DJ et al: Imaging of Paget disease of bone and its musculoskeletal complications: review. AJR Am J Roentgenol. 196(6 Suppl):S64-75, 2011
                                                                                          8. Varenna M et al: Demographic and clinical features related to a symptomatic onset of Paget's disease of bone. J Rheumatol. 37(1):155-60, 2010
                                                                                          9. Merchant A et al: Somatic mutations in SQSTM1 detected in affected tissues from patients with sporadic Paget's disease of bone. J Bone Miner Res. 24(3):484-94, 2009
                                                                                          10. Colina M et al: Paget's disease of bone: a review. Rheumatol Int. 28(11):1069-75, 2008
                                                                                          11. Kimonis VE et al: Clinical studies in familial VCP myopathy associated with Paget disease of bone and frontotemporal dementia. Am J Med Genet A. 146A(6):745-57, 2008
                                                                                          12. Rodallec MH et al: Diagnostic imaging of solitary tumors of the spine: what to do and say. Radiographics. 28(4):1019-41, 2008
                                                                                          13. Tessitore E et al: Cervical Paget disease of bone with spinal cord compression due to atlanto-axial instability: a case report and review of the literature. Spine (Phila Pa 1976). 33(3):E85-9, 2008
                                                                                          14. Oikonomou A et al: Paget disease of the spine manifested by thoracic and lumbar epidural lipomatosis: magnetic resonance imaging findings. Spine (Phila Pa 1976). 32(25):E789-92, 2007
                                                                                          15. Hansen MF et al: Osteosarcoma in Paget's disease of bone. J Bone Miner Res. 21 Suppl 2:P58-63, 2006
                                                                                          16. Saifuddin A et al: Paget's disease of the spine: unusual features and complications. Clin Radiol. 58(2):102-11, 2003
                                                                                          17. Spieth ME et al: Positron emission tomography and Paget disease: hot is not necessarily malignant. Clin Nucl Med. 28(9):773-4, 2003
                                                                                          18. Smith SE et al: From the archives of the AFIP. Radiologic spectrum of Paget disease of bone and its complications with pathologic correlation. Radiographics. 22(5):1191-216, 2002
                                                                                          19. Whitehouse RW: Paget's disease of bone. Semin Musculoskelet Radiol. 6(4):313-22, 2002
                                                                                          20. Hadjipavlou AG et al: Paget's disease of the spine and its management. Eur Spine J. 10(5):370-84, 2001
                                                                                          21. Vande Berg BC et al: Magnetic resonance appearance of uncomplicated Paget's disease of bone. Semin Musculoskelet Radiol. 5(1):69-77, 2001
                                                                                          22. Poncelet A: The neurologic complications of Paget's disease. J Bone Miner Res. 14 Suppl 2:88-91, 1999
                                                                                          23. Boutin RD et al: Complications in Paget disease at MR imaging. Radiology. 209(3):641-51, 1998
                                                                                          24. Cook GJ et al: Fluorine-18-FDG PET in Paget's disease of bone. J Nucl Med. 38(9):1495-7, 1997
                                                                                          25. Klein RM et al: Diagnostic procedures for Paget's disease. Radiologic, pathologic, and laboratory testing. Endocrinol Metab Clin North Am. 24(2):437-50, 1995
                                                                                          26. Mirra JM et al: Paget's disease of bone: review with emphasis on radiologic features, Part I. Skeletal Radiol. 24(3):163-71, 1995
                                                                                          27. Mirra JM et al: Paget's disease of bone: review with emphasis on radiologic features, Part II. Skeletal Radiol. 24(3):173-84, 1995
                                                                                          28. Hadjipavlou A et al: Malignant transformation in Paget disease of bone. Cancer. 70(12):2802-8, 1992
                                                                                          29. Ryan MD et al: Spinal manifestations of Paget's disease. Aust N Z J Surg. 62(1):33-8, 1992
                                                                                          30. Roberts MC et al: Paget disease: MR imaging findings. Radiology. 173(2):341-5, 1989
                                                                                          31. Vellenga CJ et al: Bone scintigraphy and radiology in Paget's disease of bone: a review. Am J Physiol Imaging. 3(3):154-68, 1988
                                                                                          32. Frame B et al: Paget disease: a review of current knowledge. Radiology. 141(1):21-4, 1981