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Paget Disease
Anne G. Osborn, MD, FACR; Miral D. Jhaveri, MD, MBA
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Paget disease (PD)
            • Synonyms

              • Osteitis deformans
            • Definitions

              • Chronic metabolic skeletal disorder
              • Characterized by bony expansion with variable destruction ± sclerosis

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Nuclear Medicine Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        Selected References

                                        1. Cronin O et al: Characteristics of early Paget's disease in SQSTM1 mutation carriers: baseline analysis of the ZiPP study cohort. J Bone Miner Res. ePub, 2020
                                        2. Omar AT 2nd et al: Management of hydrocephalus in Paget's disease of bone: systematic review and illustrative case. World Neurosurg. 135:e640-9, 2020
                                        3. Bou Antoun M et al: The lucent (CT) and enhancing (MR) rim, a sign of Paget's disease of the skull: case report. Skeletal Radiol. 47(11):1567-70, 2018
                                        4. Kravets I: Paget's disease of bone: diagnosis and treatment. Am J Med. 131(11):1298-303, 2018
                                        5. Czerniak B et al. Dorfman and Czerniak's Bone Tumors. Philadelphia, PA: Elsevier, 2016
                                        6. Sandford A et al: The 'cotton wool' sign in paget's disease of the skull. QJM. 109(2):131, 2016
                                        7. Wodajo FM: Top five lesions that do not need referral to orthopedic oncology. Orthop Clin North Am. 46(2):303-14, 2015
                                        8. Galson DL et al: Pathobiology of Paget's disease of bone. J Bone Metab. 21(2):85-98, 2014
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Pathology

                                                • Clinical Issues

                                                  TERMINOLOGY

                                                  • Abbreviations

                                                    • Paget disease (PD)
                                                  • Synonyms

                                                    • Osteitis deformans
                                                  • Definitions

                                                    • Chronic metabolic skeletal disorder
                                                    • Characterized by bony expansion with variable destruction ± sclerosis

                                                  IMAGING

                                                  • General Features

                                                    • Radiographic Findings

                                                      • CT Findings

                                                        • MR Findings

                                                          • Nuclear Medicine Findings

                                                            • Imaging Recommendations

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Gross Pathologic & Surgical Features

                                                                    • Microscopic Features

                                                                      CLINICAL ISSUES

                                                                      • Presentation

                                                                        • Demographics

                                                                          • Natural History & Prognosis

                                                                            • Treatment

                                                                              Selected References

                                                                              1. Cronin O et al: Characteristics of early Paget's disease in SQSTM1 mutation carriers: baseline analysis of the ZiPP study cohort. J Bone Miner Res. ePub, 2020
                                                                              2. Omar AT 2nd et al: Management of hydrocephalus in Paget's disease of bone: systematic review and illustrative case. World Neurosurg. 135:e640-9, 2020
                                                                              3. Bou Antoun M et al: The lucent (CT) and enhancing (MR) rim, a sign of Paget's disease of the skull: case report. Skeletal Radiol. 47(11):1567-70, 2018
                                                                              4. Kravets I: Paget's disease of bone: diagnosis and treatment. Am J Med. 131(11):1298-303, 2018
                                                                              5. Czerniak B et al. Dorfman and Czerniak's Bone Tumors. Philadelphia, PA: Elsevier, 2016
                                                                              6. Sandford A et al: The 'cotton wool' sign in paget's disease of the skull. QJM. 109(2):131, 2016
                                                                              7. Wodajo FM: Top five lesions that do not need referral to orthopedic oncology. Orthop Clin North Am. 46(2):303-14, 2015
                                                                              8. Galson DL et al: Pathobiology of Paget's disease of bone. J Bone Metab. 21(2):85-98, 2014