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Paget Disease
Jeffrey S. Ross, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Paget disease (PD)
            • Synonyms

              • Osteitis deformans
            • Definitions

              • Chronic metabolic disorder of abnormal bone remodeling in adult skeleton

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Nuclear Medicine Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Image Interpretation Pearls

                                          Selected References

                                          1. Ralston SH: Clinical practice. Paget's disease of bone. N Engl J Med. 368(7):644-50, 2013
                                          2. Theodorou DJ et al: Imaging of Paget disease of bone and its musculoskeletal complications: review. AJR Am J Roentgenol. 196(6 Suppl):S64-75, 2011
                                          3. Varenna M et al: Demographic and clinical features related to a symptomatic onset of Paget's disease of bone. J Rheumatol. 37(1):155-60, 2010
                                          4. Merchant A et al: Somatic mutations in SQSTM1 detected in affected tissues from patients with sporadic Paget's disease of bone. J Bone Miner Res. 24(3):484-94, 2009
                                          5. Colina M et al: Paget's disease of bone: a review. Rheumatol Int. 28(11):1069-75, 2008
                                          6. Kimonis VE et al: Clinical studies in familial VCP myopathy associated with Paget disease of bone and frontotemporal dementia. Am J Med Genet A. 146A(6):745-57, 2008
                                          7. Rodallec MH et al: Diagnostic imaging of solitary tumors of the spine: what to do and say. Radiographics. 28(4):1019-41, 2008
                                          8. Tessitore E et al: Cervical Paget disease of bone with spinal cord compression due to atlanto-axial instability: a case report and review of the literature. Spine (Phila Pa 1976). 33(3):E85-9, 2008
                                          9. Oikonomou A et al: Paget disease of the spine manifested by thoracic and lumbar epidural lipomatosis: magnetic resonance imaging findings. Spine (Phila Pa 1976). 32(25):E789-92, 2007
                                          10. Hansen MF et al: Osteosarcoma in Paget's disease of bone. J Bone Miner Res. 21 Suppl 2:P58-63, 2006
                                          11. Saifuddin A et al: Paget's disease of the spine: unusual features and complications. Clin Radiol. 58(2):102-11, 2003
                                          12. Spieth ME et al: Positron emission tomography and Paget disease: hot is not necessarily malignant. Clin Nucl Med. 28(9):773-4, 2003
                                          13. Smith SE et al: From the archives of the AFIP. Radiologic spectrum of Paget disease of bone and its complications with pathologic correlation. Radiographics. 22(5):1191-216, 2002
                                          14. Whitehouse RW: Paget's disease of bone. Semin Musculoskelet Radiol. 6(4):313-22, 2002
                                          15. Hadjipavlou AG et al: Paget's disease of the spine and its management. Eur Spine J. 10(5):370-84, 2001
                                          16. Vande Berg BC et al: Magnetic resonance appearance of uncomplicated Paget's disease of bone. Semin Musculoskelet Radiol. 5(1):69-77, 2001
                                          17. Poncelet A: The neurologic complications of Paget's disease. J Bone Miner Res. 14 Suppl 2:88-91, 1999
                                          18. Boutin RD et al: Complications in Paget disease at MR imaging. Radiology. 209(3):641-51, 1998
                                          19. Cook GJ et al: Fluorine-18-FDG PET in Paget's disease of bone. J Nucl Med. 38(9):1495-7, 1997
                                          20. Klein RM et al: Diagnostic procedures for Paget's disease. Radiologic, pathologic, and laboratory testing. Endocrinol Metab Clin North Am. 24(2):437-50, 1995
                                          21. Mirra JM et al: Paget's disease of bone: review with emphasis on radiologic features, Part I. Skeletal Radiol. 24(3):163-71, 1995
                                          22. Mirra JM et al: Paget's disease of bone: review with emphasis on radiologic features, Part II. Skeletal Radiol. 24(3):173-84, 1995
                                          23. Hadjipavlou A et al: Malignant transformation in Paget disease of bone. Cancer. 70(12):2802-8, 1992
                                          24. Ryan MD et al: Spinal manifestations of Paget's disease. Aust N Z J Surg. 62(1):33-8, 1992
                                          25. Roberts MC et al: Paget disease: MR imaging findings. Radiology. 173(2):341-5, 1989
                                          26. Vellenga CJ et al: Bone scintigraphy and radiology in Paget's disease of bone: a review. Am J Physiol Imaging. 3(3):154-68, 1988
                                          27. Frame B et al: Paget disease: a review of current knowledge. Radiology. 141(1):21-4, 1981
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Pathology

                                                  • Clinical Issues

                                                    TERMINOLOGY

                                                    • Abbreviations

                                                      • Paget disease (PD)
                                                    • Synonyms

                                                      • Osteitis deformans
                                                    • Definitions

                                                      • Chronic metabolic disorder of abnormal bone remodeling in adult skeleton

                                                    IMAGING

                                                    • General Features

                                                      • Radiographic Findings

                                                        • CT Findings

                                                          • MR Findings

                                                            • Nuclear Medicine Findings

                                                              • Imaging Recommendations

                                                                DIFFERENTIAL DIAGNOSIS

                                                                  PATHOLOGY

                                                                  • General Features

                                                                    • Gross Pathologic & Surgical Features

                                                                      • Microscopic Features

                                                                        CLINICAL ISSUES

                                                                        • Presentation

                                                                          • Demographics

                                                                            • Natural History & Prognosis

                                                                              • Treatment

                                                                                DIAGNOSTIC CHECKLIST

                                                                                • Image Interpretation Pearls

                                                                                  Selected References

                                                                                  1. Ralston SH: Clinical practice. Paget's disease of bone. N Engl J Med. 368(7):644-50, 2013
                                                                                  2. Theodorou DJ et al: Imaging of Paget disease of bone and its musculoskeletal complications: review. AJR Am J Roentgenol. 196(6 Suppl):S64-75, 2011
                                                                                  3. Varenna M et al: Demographic and clinical features related to a symptomatic onset of Paget's disease of bone. J Rheumatol. 37(1):155-60, 2010
                                                                                  4. Merchant A et al: Somatic mutations in SQSTM1 detected in affected tissues from patients with sporadic Paget's disease of bone. J Bone Miner Res. 24(3):484-94, 2009
                                                                                  5. Colina M et al: Paget's disease of bone: a review. Rheumatol Int. 28(11):1069-75, 2008
                                                                                  6. Kimonis VE et al: Clinical studies in familial VCP myopathy associated with Paget disease of bone and frontotemporal dementia. Am J Med Genet A. 146A(6):745-57, 2008
                                                                                  7. Rodallec MH et al: Diagnostic imaging of solitary tumors of the spine: what to do and say. Radiographics. 28(4):1019-41, 2008
                                                                                  8. Tessitore E et al: Cervical Paget disease of bone with spinal cord compression due to atlanto-axial instability: a case report and review of the literature. Spine (Phila Pa 1976). 33(3):E85-9, 2008
                                                                                  9. Oikonomou A et al: Paget disease of the spine manifested by thoracic and lumbar epidural lipomatosis: magnetic resonance imaging findings. Spine (Phila Pa 1976). 32(25):E789-92, 2007
                                                                                  10. Hansen MF et al: Osteosarcoma in Paget's disease of bone. J Bone Miner Res. 21 Suppl 2:P58-63, 2006
                                                                                  11. Saifuddin A et al: Paget's disease of the spine: unusual features and complications. Clin Radiol. 58(2):102-11, 2003
                                                                                  12. Spieth ME et al: Positron emission tomography and Paget disease: hot is not necessarily malignant. Clin Nucl Med. 28(9):773-4, 2003
                                                                                  13. Smith SE et al: From the archives of the AFIP. Radiologic spectrum of Paget disease of bone and its complications with pathologic correlation. Radiographics. 22(5):1191-216, 2002
                                                                                  14. Whitehouse RW: Paget's disease of bone. Semin Musculoskelet Radiol. 6(4):313-22, 2002
                                                                                  15. Hadjipavlou AG et al: Paget's disease of the spine and its management. Eur Spine J. 10(5):370-84, 2001
                                                                                  16. Vande Berg BC et al: Magnetic resonance appearance of uncomplicated Paget's disease of bone. Semin Musculoskelet Radiol. 5(1):69-77, 2001
                                                                                  17. Poncelet A: The neurologic complications of Paget's disease. J Bone Miner Res. 14 Suppl 2:88-91, 1999
                                                                                  18. Boutin RD et al: Complications in Paget disease at MR imaging. Radiology. 209(3):641-51, 1998
                                                                                  19. Cook GJ et al: Fluorine-18-FDG PET in Paget's disease of bone. J Nucl Med. 38(9):1495-7, 1997
                                                                                  20. Klein RM et al: Diagnostic procedures for Paget's disease. Radiologic, pathologic, and laboratory testing. Endocrinol Metab Clin North Am. 24(2):437-50, 1995
                                                                                  21. Mirra JM et al: Paget's disease of bone: review with emphasis on radiologic features, Part I. Skeletal Radiol. 24(3):163-71, 1995
                                                                                  22. Mirra JM et al: Paget's disease of bone: review with emphasis on radiologic features, Part II. Skeletal Radiol. 24(3):173-84, 1995
                                                                                  23. Hadjipavlou A et al: Malignant transformation in Paget disease of bone. Cancer. 70(12):2802-8, 1992
                                                                                  24. Ryan MD et al: Spinal manifestations of Paget's disease. Aust N Z J Surg. 62(1):33-8, 1992
                                                                                  25. Roberts MC et al: Paget disease: MR imaging findings. Radiology. 173(2):341-5, 1989
                                                                                  26. Vellenga CJ et al: Bone scintigraphy and radiology in Paget's disease of bone: a review. Am J Physiol Imaging. 3(3):154-68, 1988
                                                                                  27. Frame B et al: Paget disease: a review of current knowledge. Radiology. 141(1):21-4, 1981