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Nuclear Medicine
Musculoskeletal
Bone Dysplasias
Paget Disease
Paget Disease
Fathima Fijula P. Manzil, MD
;
Umesh D. Oza, MD
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KEY FACTS
Terminology
Imaging
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Definitions
Paget disease (PD) of bone
Disorder of abnormal/excessive bone remodeling characterized by coarse trabeculae, sclerosis, and expansion of ≥ 1 bones
Active disease begins with osteolytic phase followed by sclerotic or mixed active phase; inactive or quiescent phase demonstrates sclerotic lesions
Although thickened, abnormal bone is weaker and bone deformity or fracture is common
a.k.a. osteitis deformans, osteoporosis circumscripta (skull)
IMAGING
General Features
Nuclear Medicine Findings
Radiographic Findings
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
Kravets I: Paget's disease of bone: Diagnosis and treatment. Am J Med. 131(11):1298-303, 2018
Wassef HR et al: Nuclear medicine imaging in the dentomaxillofacial region. Dent Clin North Am. 62(3):491-509, 2018
Ralston SH et al: Pathogenesis of Paget disease of bone. Calcif Tissue Int. 91(2):97-113, 2012
Cortis K et al: Imaging Paget's disease of bone--from head to toe. Clin Radiol. 66(7):662-72, 2011
Theodorou DJ et al: Imaging of Paget disease of bone and its musculoskeletal complications: review. AJR Am J Roentgenol. 196(6 Suppl):S64-75, 2011
Layfield R: The molecular pathogenesis of Paget disease of bone. Expert Rev Mol Med. 9(27):1-13, 2007
Installé J et al: (18)F-fluoride PET for monitoring therapeutic response in Paget's disease of bone. J Nucl Med. 46(10):1650-8, 2005
Spieth ME et al: Positron emission tomography and Paget disease: hot is not necessarily malignant. Clin Nucl Med. 28(9):773-4, 2003
Cook GJ et al: Fluorine-18-FDG PET in Paget's disease of bone. J Nucl Med. 38(9):1495-7, 1997
Bahk YW et al: Bone pathologic correlation of multimodality imaging in Paget's disease. J Nucl Med. 36(8):1421-6, 1995
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Definitions
Paget disease (PD) of bone
Disorder of abnormal/excessive bone remodeling characterized by coarse trabeculae, sclerosis, and expansion of ≥ 1 bones
Active disease begins with osteolytic phase followed by sclerotic or mixed active phase; inactive or quiescent phase demonstrates sclerotic lesions
Although thickened, abnormal bone is weaker and bone deformity or fracture is common
a.k.a. osteitis deformans, osteoporosis circumscripta (skull)
IMAGING
General Features
Nuclear Medicine Findings
Radiographic Findings
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
Kravets I: Paget's disease of bone: Diagnosis and treatment. Am J Med. 131(11):1298-303, 2018
Wassef HR et al: Nuclear medicine imaging in the dentomaxillofacial region. Dent Clin North Am. 62(3):491-509, 2018
Ralston SH et al: Pathogenesis of Paget disease of bone. Calcif Tissue Int. 91(2):97-113, 2012
Cortis K et al: Imaging Paget's disease of bone--from head to toe. Clin Radiol. 66(7):662-72, 2011
Theodorou DJ et al: Imaging of Paget disease of bone and its musculoskeletal complications: review. AJR Am J Roentgenol. 196(6 Suppl):S64-75, 2011
Layfield R: The molecular pathogenesis of Paget disease of bone. Expert Rev Mol Med. 9(27):1-13, 2007
Installé J et al: (18)F-fluoride PET for monitoring therapeutic response in Paget's disease of bone. J Nucl Med. 46(10):1650-8, 2005
Spieth ME et al: Positron emission tomography and Paget disease: hot is not necessarily malignant. Clin Nucl Med. 28(9):773-4, 2003
Cook GJ et al: Fluorine-18-FDG PET in Paget's disease of bone. J Nucl Med. 38(9):1495-7, 1997
Bahk YW et al: Bone pathologic correlation of multimodality imaging in Paget's disease. J Nucl Med. 36(8):1421-6, 1995
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