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Head and Neck
Diagnosis
Oral Cavity
Benign Tumors
Palate Benign Mixed Tumor
Palate Benign Mixed Tumor
Bronwyn E. Hamilton, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Palate benign mixed tumor (BMT)

            • Synonyms

              • Palate pleomorphic adenoma

            • Definitions

              • Benign tumor arising from palate minor salivary glands

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Angiographic Findings

                    • Nuclear Medicine Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Image Interpretation Pearls

                                            Selected References

                                            1. Kim HY et al: Clinical difference between benign and malignant tumors of the hard palate. Eur Arch Otorhinolaryngol. 277(3):903-7, 2020
                                            2. Singh M et al: Utility of fine needle aspiration in diagnosis of intraoral minor salivary gland tumors. J Cytol. 37(1):53-7, 2020
                                            3. Moon SY: Surgical management of the palatal pleomorphic adenoma. J Craniofac Surg. 30(6):e580-2, 2019
                                            4. Egal ES et al: Age and adenoma size are independent risk factors for the development of carcinoma ex pleomorphic adenoma. Oral Oncol. 84:106-7, 2018
                                            5. Kato H et al: Pleomorphic adenoma of salivary glands: common and uncommon CT and MR imaging features. Jpn J Radiol. 36(8):463-71, 2018
                                            6. Wu YC et al: Clinicopathological study of 74 palatal pleomorphic adenomas. J Formos Med Assoc. 115(1):25-30, 2016
                                            7. Aydil U et al: Neoplasms of the hard palate. J Oral Maxillofac Surg. 72(3):619-26, 2014
                                            8. Kato H et al: CT and MR imaging findings of palatal tumors. Eur J Radiol. 83(3):e137-46, 2014
                                            9. Akiba J et al: A case of metastasizing pleomorphic adenoma in the maxillary bone appearing twenty years after initial resection of pleomorphic adenoma of the hard palate. Pathol Int. 63(9):463-8, 2013
                                            10. Fu H et al: Pleomorphic adenoma of the salivary glands in children and adolescents. J Pediatr Surg. 47(4):715-9, 2012
                                            11. Matsuzaki H et al: Diagnostic value of dynamic contrast-enhanced MRI for submucosal palatal tumors. Eur J Radiol. 81(11):3306-12, 2012
                                            12. Lingam RK et al: Pleomorphic adenoma (benign mixed tumour) of the salivary glands: its diverse clinical, radiological, and histopathological presentation. Br J Oral Maxillofac Surg. 49(1):14-20, 2011
                                            13. Lee YY et al: Imaging of salivary gland tumours. Eur J Radiol. 66(3):419-36, 2008
                                            14. Pires FR et al: Intra-oral minor salivary gland tumors: a clinicopathological study of 546 cases. Oral Oncol. 43(5):463-70, 2007
                                            15. Yih WY et al: Intraoral minor salivary gland neoplasms: review of 213 cases. J Oral Maxillofac Surg. 63(6):805-10, 2005
                                            16. Cerulli G et al: Differential diagnosis between adenoid cystic carcinoma and pleomorphic adenoma of the minor salivary glands of palate. J Craniofac Surg. 15(6):1056-60, 2004
                                            17. Clauser L et al: Pleomorphic adenoma of the palate. J Craniofac Surg. 15(6):1026-9, 2004
                                            18. Białek EJ et al: Role of ultrasonography in diagnosis and differentiation of pleomorphic adenomas: work in progress. Arch Otolaryngol Head Neck Surg. 129(9):929-33, 2003
                                            19. Jansisyanont P et al: Intraoral minor salivary gland neoplasm: a single institution experience of 80 cases. Int J Oral Maxillofac Surg. 31(3):257-61, 2002
                                            20. Beckhardt RN et al: Minor salivary gland tumors of the palate: clinical and pathologic correlates of outcome. Laryngoscope. 105(11):1155-60, 1995
                                            21. Waldron CA et al: Tumors of the intraoral minor salivary glands: a demographic and histologic study of 426 cases. Oral Surg Oral Med Oral Pathol. 66(3):323-33, 1988
                                            22. Ma DQ et al: Tumours of the minor salivary glands. A clinicopathologic study of 243 cases. Acta Otolaryngol. 103(3-4):325-31, 1987
                                            23. Pinto RS et al: Radiologic features of benign pleomorphic adenoma of the hard palate. Oral Surg Oral Med Oral Pathol. 39(6):976-81, 1975
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Pathology

                                                    • Clinical Issues

                                                      TERMINOLOGY

                                                      • Abbreviations

                                                        • Palate benign mixed tumor (BMT)

                                                      • Synonyms

                                                        • Palate pleomorphic adenoma

                                                      • Definitions

                                                        • Benign tumor arising from palate minor salivary glands

                                                      IMAGING

                                                      • General Features

                                                        • CT Findings

                                                          • MR Findings

                                                            • Angiographic Findings

                                                              • Nuclear Medicine Findings

                                                                • Imaging Recommendations

                                                                  DIFFERENTIAL DIAGNOSIS

                                                                    PATHOLOGY

                                                                    • General Features

                                                                      • Gross Pathologic & Surgical Features

                                                                        • Microscopic Features

                                                                          CLINICAL ISSUES

                                                                          • Presentation

                                                                            • Demographics

                                                                              • Natural History & Prognosis

                                                                                • Treatment

                                                                                  DIAGNOSTIC CHECKLIST

                                                                                  • Consider

                                                                                    • Image Interpretation Pearls

                                                                                      Selected References

                                                                                      1. Kim HY et al: Clinical difference between benign and malignant tumors of the hard palate. Eur Arch Otorhinolaryngol. 277(3):903-7, 2020
                                                                                      2. Singh M et al: Utility of fine needle aspiration in diagnosis of intraoral minor salivary gland tumors. J Cytol. 37(1):53-7, 2020
                                                                                      3. Moon SY: Surgical management of the palatal pleomorphic adenoma. J Craniofac Surg. 30(6):e580-2, 2019
                                                                                      4. Egal ES et al: Age and adenoma size are independent risk factors for the development of carcinoma ex pleomorphic adenoma. Oral Oncol. 84:106-7, 2018
                                                                                      5. Kato H et al: Pleomorphic adenoma of salivary glands: common and uncommon CT and MR imaging features. Jpn J Radiol. 36(8):463-71, 2018
                                                                                      6. Wu YC et al: Clinicopathological study of 74 palatal pleomorphic adenomas. J Formos Med Assoc. 115(1):25-30, 2016
                                                                                      7. Aydil U et al: Neoplasms of the hard palate. J Oral Maxillofac Surg. 72(3):619-26, 2014
                                                                                      8. Kato H et al: CT and MR imaging findings of palatal tumors. Eur J Radiol. 83(3):e137-46, 2014
                                                                                      9. Akiba J et al: A case of metastasizing pleomorphic adenoma in the maxillary bone appearing twenty years after initial resection of pleomorphic adenoma of the hard palate. Pathol Int. 63(9):463-8, 2013
                                                                                      10. Fu H et al: Pleomorphic adenoma of the salivary glands in children and adolescents. J Pediatr Surg. 47(4):715-9, 2012
                                                                                      11. Matsuzaki H et al: Diagnostic value of dynamic contrast-enhanced MRI for submucosal palatal tumors. Eur J Radiol. 81(11):3306-12, 2012
                                                                                      12. Lingam RK et al: Pleomorphic adenoma (benign mixed tumour) of the salivary glands: its diverse clinical, radiological, and histopathological presentation. Br J Oral Maxillofac Surg. 49(1):14-20, 2011
                                                                                      13. Lee YY et al: Imaging of salivary gland tumours. Eur J Radiol. 66(3):419-36, 2008
                                                                                      14. Pires FR et al: Intra-oral minor salivary gland tumors: a clinicopathological study of 546 cases. Oral Oncol. 43(5):463-70, 2007
                                                                                      15. Yih WY et al: Intraoral minor salivary gland neoplasms: review of 213 cases. J Oral Maxillofac Surg. 63(6):805-10, 2005
                                                                                      16. Cerulli G et al: Differential diagnosis between adenoid cystic carcinoma and pleomorphic adenoma of the minor salivary glands of palate. J Craniofac Surg. 15(6):1056-60, 2004
                                                                                      17. Clauser L et al: Pleomorphic adenoma of the palate. J Craniofac Surg. 15(6):1026-9, 2004
                                                                                      18. Białek EJ et al: Role of ultrasonography in diagnosis and differentiation of pleomorphic adenomas: work in progress. Arch Otolaryngol Head Neck Surg. 129(9):929-33, 2003
                                                                                      19. Jansisyanont P et al: Intraoral minor salivary gland neoplasm: a single institution experience of 80 cases. Int J Oral Maxillofac Surg. 31(3):257-61, 2002
                                                                                      20. Beckhardt RN et al: Minor salivary gland tumors of the palate: clinical and pathologic correlates of outcome. Laryngoscope. 105(11):1155-60, 1995
                                                                                      21. Waldron CA et al: Tumors of the intraoral minor salivary glands: a demographic and histologic study of 426 cases. Oral Surg Oral Med Oral Pathol. 66(3):323-33, 1988
                                                                                      22. Ma DQ et al: Tumours of the minor salivary glands. A clinicopathologic study of 243 cases. Acta Otolaryngol. 103(3-4):325-31, 1987
                                                                                      23. Pinto RS et al: Radiologic features of benign pleomorphic adenoma of the hard palate. Oral Surg Oral Med Oral Pathol. 39(6):976-81, 1975