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Pancreatic Ductal Carcinoma
Siva P. Raman, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Clinical Issues

        TERMINOLOGY

        • Synonyms

          • Pancreatic adenocarcinoma, pancreatic cancer
        • Definitions

          • Malignancy arising from ductal epithelium of exocrine pancreas

        IMAGING

        • General Features

          • CT Findings

            • MR Findings

              • Ultrasonographic Findings

                • Nuclear Medicine Findings

                  • Radiographic Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Image Interpretation Pearls

                                            • Reporting Tips

                                              Selected References

                                              1. Balachandran A et al: Imaging of pancreatic neoplasms. Surg Oncol Clin N Am. 23(4):751-88, 2014
                                              2. Becker AE et al: Pancreatic ductal adenocarcinoma: risk factors, screening, and early detection. World J Gastroenterol. 20(32):11182-98, 2014
                                              3. Loc WS et al: Novel strategies for managing pancreatic cancer. World J Gastroenterol. 20(40):14717-14725, 2014
                                              4. O'Neill E et al: MR imaging of the pancreas. Radiol Clin North Am. 52(4):757-77, 2014
                                              5. Raman SP et al: Abnormalities of the Distal Common Bile Duct and Ampulla: Diagnostic Approach and Differential Diagnosis Using Multiplanar Reformations and 3D Imaging. AJR Am J Roentgenol. 203(1):17-28, 2014
                                              6. Rossi ML et al: Therapeutic options for the management of pancreatic cancer. World J Gastroenterol. 20(32):11142-59, 2014
                                              7. Wang XY et al: Utility of PET/CT in diagnosis, staging, assessment of resectability and metabolic response of pancreatic cancer. World J Gastroenterol. 20(42):15580-15589, 2014
                                              8. Al-Hawary MM et al: Mimics of pancreatic ductal adenocarcinoma. Cancer Imaging. 13(3):342-9, 2013
                                              9. Raman SP et al: Endoscopic ultrasound and pancreatic applications: what the radiologist needs to know. Abdom Imaging. 38(6):1360-72, 2013
                                              10. Coakley FV et al: Pancreatic imaging mimics: part 1, imaging mimics of pancreatic adenocarcinoma. AJR Am J Roentgenol. 199(2):301-8, 2012
                                              11. Jeffrey RB: Pancreatic cancer: radiologic imaging. Gastroenterol Clin North Am. 41(1):159-77, 2012
                                              12. Raman SP et al: Multimodality imaging of pancreatic cancer-computed tomography, magnetic resonance imaging, and positron emission tomography. Cancer J. 18(6):511-22, 2012
                                              13. Low G et al: Multimodality imaging of neoplastic and nonneoplastic solid lesions of the pancreas. Radiographics. 31(4):993-1015, 2011
                                              14. Wang Y et al: Diffusion-weighted MR imaging of solid and cystic lesions of the pancreas. Radiographics. 2011 May-Jun;31(3):E47-64. Review. Erratum in: Radiographics. 31(5):1496, 2011
                                              15. Deshmukh SD et al: Pathways of extrapancreatic perineural invasion by pancreatic adenocarcinoma: evaluation with 3D volume-rendered MDCT imaging. AJR Am J Roentgenol. 194(3):668-74, 2010
                                              16. Morana G et al: Staging cancer of the pancreas. Cancer Imaging. 10 Spec no A:S137-41, 2010
                                              17. Kauhanen SP et al: A prospective diagnostic accuracy study of 18F-fluorodeoxyglucose positron emission tomography/computed tomography, multidetector row computed tomography, and magnetic resonance imaging in primary diagnosis and staging of pancreatic cancer. Ann Surg. 250(6):957-63, 2009
                                              18. Varadhachary GR et al: Borderline resectable pancreatic cancer: definitions, management, and role of preoperative therapy. Ann Surg Oncol. 13(8):1035-46, 2006
                                              Related Anatomy
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                                              Related Differential Diagnoses
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                                              References
                                              Tables

                                              Tables

                                              KEY FACTS

                                              • Terminology

                                                • Imaging

                                                  • Clinical Issues

                                                    TERMINOLOGY

                                                    • Synonyms

                                                      • Pancreatic adenocarcinoma, pancreatic cancer
                                                    • Definitions

                                                      • Malignancy arising from ductal epithelium of exocrine pancreas

                                                    IMAGING

                                                    • General Features

                                                      • CT Findings

                                                        • MR Findings

                                                          • Ultrasonographic Findings

                                                            • Nuclear Medicine Findings

                                                              • Radiographic Findings

                                                                • Imaging Recommendations

                                                                  DIFFERENTIAL DIAGNOSIS

                                                                    PATHOLOGY

                                                                    • General Features

                                                                      • Staging, Grading, & Classification

                                                                        • Gross Pathologic & Surgical Features

                                                                          • Microscopic Features

                                                                            CLINICAL ISSUES

                                                                            • Presentation

                                                                              • Demographics

                                                                                • Natural History & Prognosis

                                                                                  • Treatment

                                                                                    DIAGNOSTIC CHECKLIST

                                                                                    • Consider

                                                                                      • Image Interpretation Pearls

                                                                                        • Reporting Tips

                                                                                          Selected References

                                                                                          1. Balachandran A et al: Imaging of pancreatic neoplasms. Surg Oncol Clin N Am. 23(4):751-88, 2014
                                                                                          2. Becker AE et al: Pancreatic ductal adenocarcinoma: risk factors, screening, and early detection. World J Gastroenterol. 20(32):11182-98, 2014
                                                                                          3. Loc WS et al: Novel strategies for managing pancreatic cancer. World J Gastroenterol. 20(40):14717-14725, 2014
                                                                                          4. O'Neill E et al: MR imaging of the pancreas. Radiol Clin North Am. 52(4):757-77, 2014
                                                                                          5. Raman SP et al: Abnormalities of the Distal Common Bile Duct and Ampulla: Diagnostic Approach and Differential Diagnosis Using Multiplanar Reformations and 3D Imaging. AJR Am J Roentgenol. 203(1):17-28, 2014
                                                                                          6. Rossi ML et al: Therapeutic options for the management of pancreatic cancer. World J Gastroenterol. 20(32):11142-59, 2014
                                                                                          7. Wang XY et al: Utility of PET/CT in diagnosis, staging, assessment of resectability and metabolic response of pancreatic cancer. World J Gastroenterol. 20(42):15580-15589, 2014
                                                                                          8. Al-Hawary MM et al: Mimics of pancreatic ductal adenocarcinoma. Cancer Imaging. 13(3):342-9, 2013
                                                                                          9. Raman SP et al: Endoscopic ultrasound and pancreatic applications: what the radiologist needs to know. Abdom Imaging. 38(6):1360-72, 2013
                                                                                          10. Coakley FV et al: Pancreatic imaging mimics: part 1, imaging mimics of pancreatic adenocarcinoma. AJR Am J Roentgenol. 199(2):301-8, 2012
                                                                                          11. Jeffrey RB: Pancreatic cancer: radiologic imaging. Gastroenterol Clin North Am. 41(1):159-77, 2012
                                                                                          12. Raman SP et al: Multimodality imaging of pancreatic cancer-computed tomography, magnetic resonance imaging, and positron emission tomography. Cancer J. 18(6):511-22, 2012
                                                                                          13. Low G et al: Multimodality imaging of neoplastic and nonneoplastic solid lesions of the pancreas. Radiographics. 31(4):993-1015, 2011
                                                                                          14. Wang Y et al: Diffusion-weighted MR imaging of solid and cystic lesions of the pancreas. Radiographics. 2011 May-Jun;31(3):E47-64. Review. Erratum in: Radiographics. 31(5):1496, 2011
                                                                                          15. Deshmukh SD et al: Pathways of extrapancreatic perineural invasion by pancreatic adenocarcinoma: evaluation with 3D volume-rendered MDCT imaging. AJR Am J Roentgenol. 194(3):668-74, 2010
                                                                                          16. Morana G et al: Staging cancer of the pancreas. Cancer Imaging. 10 Spec no A:S137-41, 2010
                                                                                          17. Kauhanen SP et al: A prospective diagnostic accuracy study of 18F-fluorodeoxyglucose positron emission tomography/computed tomography, multidetector row computed tomography, and magnetic resonance imaging in primary diagnosis and staging of pancreatic cancer. Ann Surg. 250(6):957-63, 2009
                                                                                          18. Varadhachary GR et al: Borderline resectable pancreatic cancer: definitions, management, and role of preoperative therapy. Ann Surg Oncol. 13(8):1035-46, 2006