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Pancreatic Neuroendocrine Neoplasm
Tara A. Morgan, MD
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KEY FACTS

  • Imaging

    • Top Differential Diagnoses

      • Pathology

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Synonyms

              • Neuroendocrine tumor, neuroendocrine carcinoma

            IMAGING

            • General Features

              • Ultrasonographic Findings

                • CT Findings

                  • MR Findings

                    • Nuclear Medicine Findings

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    Selected References

                                    1. Walczyk J et al: Diagnostic imaging of gastrointestinal neuroendocrine neoplasms with a focus on ultrasound. J Ultrason. 19(78):228-35, 2019
                                    2. Sanli Y et al: Neuroendocrine tumor diagnosis and management: 68Ga-DOTATATE PET/CT. AJR Am J Roentgenol. 211(2):267-77, 2018
                                    3. Braden B et al: B-mode and contrast-enhancement characteristics of small nonincidental neuroendocrine pancreatic tumors. Endosc Ultrasound. 6(1):49-54, 2017
                                    4. Hofman MS et al: Somatostatin receptor imaging with 68Ga DOTATATE PET/CT: clinical utility, normal patterns, pearls, and pitfalls in interpretation. Radiographics. 35(2):500-16, 2015
                                    5. Kartalis N et al: Recent developments in imaging of pancreatic neuroendocrine tumors. Ann Gastroenterol. 28(2):193-202, 2015
                                    6. Kim KW et al: Update on the management of gastroenteropancreatic neuroendocrine tumors with emphasis on the role of imaging. AJR Am J Roentgenol. 201(4):811-24, 2013
                                    7. Sahani DV et al: Gastroenteropancreatic neuroendocrine tumors: role of imaging in diagnosis and management. Radiology. 266(1):38-61, 2013
                                    8. Milan SA et al: Neuroendocrine tumors of the pancreas. Curr Opin Oncol. 24(1):46-55, 2012
                                    9. Klimstra DS et al: The pathologic classification of neuroendocrine tumors: a review of nomenclature, grading, and staging systems. Pancreas. 39(6):707-12, 2010
                                    10. Lewis RB et al: Pancreatic endocrine tumors: radiologic-clinicopathologic correlation. Radiographics. 30(6):1445-64, 2010
                                    11. Herwick S et al: MRI of islet cell tumors of the pancreas. AJR Am J Roentgenol. 187(5):W472-80, 2006
                                    12. Horton KM et al: Multi-detector row CT of pancreatic islet cell tumors. Radiographics. 26(2):453-64, 2006
                                    13. Proye CA et al: Current concepts in functioning endocrine tumors of the pancreas. World J Surg. 28(12):1231-8, 2004
                                    14. Marcos HB et al: Neuroendocrine tumors of the pancreas in von Hippel-Lindau disease: spectrum of appearances at CT and MR imaging with histopathologic comparison. Radiology. 225(3):751-8, 2002
                                    15. Theni RF et al: Detection of small, functional islet cell tumors in the pancreas: selection of imaging sequences for optimal sensitivity. Radiology. 214(2):483-90, 2000
                                    16. Vazquez Sequeiros E et al: The role of endoscopic ultrasonography in diagnosis, staging, and management of pancreatic disease states. Curr Gastroenterol Rep. 2(2):125-32, 2000
                                    Related Anatomy
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                                    Related Differential Diagnoses
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                                    References
                                    Tables

                                    Tables

                                    KEY FACTS

                                    • Imaging

                                      • Top Differential Diagnoses

                                        • Pathology

                                          • Clinical Issues

                                            • Diagnostic Checklist

                                              TERMINOLOGY

                                              • Synonyms

                                                • Neuroendocrine tumor, neuroendocrine carcinoma

                                              IMAGING

                                              • General Features

                                                • Ultrasonographic Findings

                                                  • CT Findings

                                                    • MR Findings

                                                      • Nuclear Medicine Findings

                                                        DIFFERENTIAL DIAGNOSIS

                                                          PATHOLOGY

                                                          • General Features

                                                            • Staging, Grading, & Classification

                                                              CLINICAL ISSUES

                                                              • Presentation

                                                                • Demographics

                                                                  • Natural History & Prognosis

                                                                    • Treatment

                                                                      Selected References

                                                                      1. Walczyk J et al: Diagnostic imaging of gastrointestinal neuroendocrine neoplasms with a focus on ultrasound. J Ultrason. 19(78):228-35, 2019
                                                                      2. Sanli Y et al: Neuroendocrine tumor diagnosis and management: 68Ga-DOTATATE PET/CT. AJR Am J Roentgenol. 211(2):267-77, 2018
                                                                      3. Braden B et al: B-mode and contrast-enhancement characteristics of small nonincidental neuroendocrine pancreatic tumors. Endosc Ultrasound. 6(1):49-54, 2017
                                                                      4. Hofman MS et al: Somatostatin receptor imaging with 68Ga DOTATATE PET/CT: clinical utility, normal patterns, pearls, and pitfalls in interpretation. Radiographics. 35(2):500-16, 2015
                                                                      5. Kartalis N et al: Recent developments in imaging of pancreatic neuroendocrine tumors. Ann Gastroenterol. 28(2):193-202, 2015
                                                                      6. Kim KW et al: Update on the management of gastroenteropancreatic neuroendocrine tumors with emphasis on the role of imaging. AJR Am J Roentgenol. 201(4):811-24, 2013
                                                                      7. Sahani DV et al: Gastroenteropancreatic neuroendocrine tumors: role of imaging in diagnosis and management. Radiology. 266(1):38-61, 2013
                                                                      8. Milan SA et al: Neuroendocrine tumors of the pancreas. Curr Opin Oncol. 24(1):46-55, 2012
                                                                      9. Klimstra DS et al: The pathologic classification of neuroendocrine tumors: a review of nomenclature, grading, and staging systems. Pancreas. 39(6):707-12, 2010
                                                                      10. Lewis RB et al: Pancreatic endocrine tumors: radiologic-clinicopathologic correlation. Radiographics. 30(6):1445-64, 2010
                                                                      11. Herwick S et al: MRI of islet cell tumors of the pancreas. AJR Am J Roentgenol. 187(5):W472-80, 2006
                                                                      12. Horton KM et al: Multi-detector row CT of pancreatic islet cell tumors. Radiographics. 26(2):453-64, 2006
                                                                      13. Proye CA et al: Current concepts in functioning endocrine tumors of the pancreas. World J Surg. 28(12):1231-8, 2004
                                                                      14. Marcos HB et al: Neuroendocrine tumors of the pancreas in von Hippel-Lindau disease: spectrum of appearances at CT and MR imaging with histopathologic comparison. Radiology. 225(3):751-8, 2002
                                                                      15. Theni RF et al: Detection of small, functional islet cell tumors in the pancreas: selection of imaging sequences for optimal sensitivity. Radiology. 214(2):483-90, 2000
                                                                      16. Vazquez Sequeiros E et al: The role of endoscopic ultrasonography in diagnosis, staging, and management of pancreatic disease states. Curr Gastroenterol Rep. 2(2):125-32, 2000