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Pancreatic Neuroendocrine Tumors
Umesh D. Oza, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Diagnostic Checklist

        TERMINOLOGY

        • Synonyms

          • Gastroenteropancreatic neuroendocrine tumor (GEP-NET), islet cell tumors
        • Definitions

          • Tumors arising from pancreatic endocrine cells (islets of Langerhans)

        IMAGING

        • General Features

          • Nuclear Medicine Findings

            • CT Findings

              • Angiographic Findings

                • MR Findings

                  • Ultrasonographic Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        • Image Interpretation Pearls

                                          Selected References

                                          1. Mansi L et al: Diagnostic imaging in neuroendocrine tumors. J Nucl Med. 55(10):1576-7, 2014
                                          2. Herwick S et al: MRI of islet cell tumors of the pancreas. AJR Am J Roentgenol. 187(5):W472-80, 2006
                                          3. Noone TC et al: Imaging and localization of islet-cell tumours of the pancreas on CT and MRI. Best Pract Res Clin Endocrinol Metab. 19(2):195-211, 2005
                                          4. Dromain C et al: MR imaging of hepatic metastases caused by neuroendocrine tumors: comparing four techniques. AJR Am J Roentgenol. 180(1):121-8, 2003
                                          5. Krausz Y et al: Somatostatin-receptor scintigraphy in the management of gastroenteropancreatic tumors. Am J Gastroenterol. 93(1):66-70, 1998
                                          6. van Eijck CH et al: The use of somatostatin receptor scintigraphy in the differential diagnosis of pancreatic duct cancers and islet cell tumors. Ann Surg. 224(2):119-24, 1996
                                          7. Becker W et al: Octreotide scintigraphy localizes somatostatin receptor-positive islet cell carcinomas. Eur J Nucl Med. 18(11):924-7, 1991
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Diagnostic Checklist

                                                TERMINOLOGY

                                                • Synonyms

                                                  • Gastroenteropancreatic neuroendocrine tumor (GEP-NET), islet cell tumors
                                                • Definitions

                                                  • Tumors arising from pancreatic endocrine cells (islets of Langerhans)

                                                IMAGING

                                                • General Features

                                                  • Nuclear Medicine Findings

                                                    • CT Findings

                                                      • Angiographic Findings

                                                        • MR Findings

                                                          • Ultrasonographic Findings

                                                            • Imaging Recommendations

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Gross Pathologic & Surgical Features

                                                                    • Microscopic Features

                                                                      CLINICAL ISSUES

                                                                      • Presentation

                                                                        • Demographics

                                                                          • Natural History & Prognosis

                                                                            • Treatment

                                                                              DIAGNOSTIC CHECKLIST

                                                                              • Consider

                                                                                • Image Interpretation Pearls

                                                                                  Selected References

                                                                                  1. Mansi L et al: Diagnostic imaging in neuroendocrine tumors. J Nucl Med. 55(10):1576-7, 2014
                                                                                  2. Herwick S et al: MRI of islet cell tumors of the pancreas. AJR Am J Roentgenol. 187(5):W472-80, 2006
                                                                                  3. Noone TC et al: Imaging and localization of islet-cell tumours of the pancreas on CT and MRI. Best Pract Res Clin Endocrinol Metab. 19(2):195-211, 2005
                                                                                  4. Dromain C et al: MR imaging of hepatic metastases caused by neuroendocrine tumors: comparing four techniques. AJR Am J Roentgenol. 180(1):121-8, 2003
                                                                                  5. Krausz Y et al: Somatostatin-receptor scintigraphy in the management of gastroenteropancreatic tumors. Am J Gastroenterol. 93(1):66-70, 1998
                                                                                  6. van Eijck CH et al: The use of somatostatin receptor scintigraphy in the differential diagnosis of pancreatic duct cancers and islet cell tumors. Ann Surg. 224(2):119-24, 1996
                                                                                  7. Becker W et al: Octreotide scintigraphy localizes somatostatin receptor-positive islet cell carcinomas. Eur J Nucl Med. 18(11):924-7, 1991