Bookmarks
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Panlobular emphysema (PLE)
- α-1-antitrypsin deficiency (α1AD or AATD)
Synonyms
- Panacinar emphysema
Definitions
- Enlargement and destruction of entire acinus or secondary pulmonary lobule
- Acinus: Lung distal to terminal bronchiole
- Respiratory bronchioles → alveolar ducts → alveolar sacs → alveoli
IMAGING
General Features
Radiographic Findings
CT Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
- Martini K et al: Advances in imaging for lung emphysema. Ann Transl Med. 8(21):1467, 2020
- Lynch DA et al: CT-based visual classification of emphysema: association with mortality in the COPDGene study. Radiology. 288(3):859-66, 2018
- Tanabe N et al: Micro-computed tomography comparison of preterminal bronchioles in centrilobular and panlobular emphysema. Am J Respir Crit Care Med. 195(5):630-8, 2017
- van Agteren JE et al: Lung volume reduction surgery for diffuse emphysema. Cochrane Database Syst Rev. 10:CD001001, 2016
- Lynch DA et al: CT-definable subtypes of chronic obstructive pulmonary disease: a statement of the Fleischner Society. Radiology. 277(1):192-205, 2015
- Smith BM et al: Pulmonary emphysema subtypes on computed tomography: the MESA COPD study. Am J Med. 127(1):94.e7-23, 2014
- Kukkonen MK et al: SERPINE2 haplotype as a risk factor for panlobular type of emphysema. BMC Med Genet. 12:157, 2011
- Litmanovich D et al: CT of pulmonary emphysema--current status, challenges, and future directions. Eur Radiol. 19(3):537-51, 2009
- Weder W et al: Persistent benefit from lung volume reduction surgery in patients with homogeneous emphysema. Ann Thorac Surg. 87(1):229-36; discussion 236-7, 2009
- Bankier AA et al: CT quantification of pulmonary emphysema: assessment of lung structure and function. Crit Rev Comput Tomogr. 43(6):399-417, 2002
- Copley SJ et al: Thin-section CT in obstructive pulmonary disease: discriminatory value. Radiology. 223(3):812-9, 2002
- Sugi K et al: The outcome of volume reduction surgery according to the underlying type of emphysema. Surg Today. 31(7):580-5, 2001
- Bankier AA et al: Pulmonary emphysema: subjective visual grading versus objective quantification with macroscopic morphometry and thin-section CT densitometry. Radiology. 211(3):851-8, 1999
- Slone RM et al: Preoperative and postoperative imaging in the surgical management of pulmonary emphysema. Radiol Clin North Am. 36(1):57-89, 1998
- Webb WR: Radiology of obstructive pulmonary disease. AJR Am J Roentgenol. 169(3):637-47, 1997
- Stern EJ et al: CT of the lungs in patients with pulmonary emphysema. Semin Ultrasound CT MR. 16(5):345-52, 1995
- Stern EJ et al: CT of the lung in patients with pulmonary emphysema: diagnosis, quantification, and correlation with pathologic and physiologic findings. AJR Am J Roentgenol. 162(4):791-8, 1994
- Stern EJ et al: Panlobular pulmonary emphysema caused by i.v. injection of methylphenidate (Ritalin): findings on chest radiographs and CT scans. AJR Am J Roentgenol. 162(3):555-60, 1994
Related Anatomy
Loading...
Related Differential Diagnoses
Loading...
References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Panlobular emphysema (PLE)
- α-1-antitrypsin deficiency (α1AD or AATD)
Synonyms
- Panacinar emphysema
Definitions
- Enlargement and destruction of entire acinus or secondary pulmonary lobule
- Acinus: Lung distal to terminal bronchiole
- Respiratory bronchioles → alveolar ducts → alveolar sacs → alveoli
IMAGING
General Features
Radiographic Findings
CT Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
- Martini K et al: Advances in imaging for lung emphysema. Ann Transl Med. 8(21):1467, 2020
- Lynch DA et al: CT-based visual classification of emphysema: association with mortality in the COPDGene study. Radiology. 288(3):859-66, 2018
- Tanabe N et al: Micro-computed tomography comparison of preterminal bronchioles in centrilobular and panlobular emphysema. Am J Respir Crit Care Med. 195(5):630-8, 2017
- van Agteren JE et al: Lung volume reduction surgery for diffuse emphysema. Cochrane Database Syst Rev. 10:CD001001, 2016
- Lynch DA et al: CT-definable subtypes of chronic obstructive pulmonary disease: a statement of the Fleischner Society. Radiology. 277(1):192-205, 2015
- Smith BM et al: Pulmonary emphysema subtypes on computed tomography: the MESA COPD study. Am J Med. 127(1):94.e7-23, 2014
- Kukkonen MK et al: SERPINE2 haplotype as a risk factor for panlobular type of emphysema. BMC Med Genet. 12:157, 2011
- Litmanovich D et al: CT of pulmonary emphysema--current status, challenges, and future directions. Eur Radiol. 19(3):537-51, 2009
- Weder W et al: Persistent benefit from lung volume reduction surgery in patients with homogeneous emphysema. Ann Thorac Surg. 87(1):229-36; discussion 236-7, 2009
- Bankier AA et al: CT quantification of pulmonary emphysema: assessment of lung structure and function. Crit Rev Comput Tomogr. 43(6):399-417, 2002
- Copley SJ et al: Thin-section CT in obstructive pulmonary disease: discriminatory value. Radiology. 223(3):812-9, 2002
- Sugi K et al: The outcome of volume reduction surgery according to the underlying type of emphysema. Surg Today. 31(7):580-5, 2001
- Bankier AA et al: Pulmonary emphysema: subjective visual grading versus objective quantification with macroscopic morphometry and thin-section CT densitometry. Radiology. 211(3):851-8, 1999
- Slone RM et al: Preoperative and postoperative imaging in the surgical management of pulmonary emphysema. Radiol Clin North Am. 36(1):57-89, 1998
- Webb WR: Radiology of obstructive pulmonary disease. AJR Am J Roentgenol. 169(3):637-47, 1997
- Stern EJ et al: CT of the lungs in patients with pulmonary emphysema. Semin Ultrasound CT MR. 16(5):345-52, 1995
- Stern EJ et al: CT of the lung in patients with pulmonary emphysema: diagnosis, quantification, and correlation with pathologic and physiologic findings. AJR Am J Roentgenol. 162(4):791-8, 1994
- Stern EJ et al: Panlobular pulmonary emphysema caused by i.v. injection of methylphenidate (Ritalin): findings on chest radiographs and CT scans. AJR Am J Roentgenol. 162(3):555-60, 1994
