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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
Invasive papillary carcinoma (IPC)
Definitions
Invasive carcinoma with > 90% exclusively papillary architecture of papillae with fibrovascular cores and lacking myoepithelial layer
Distinct from invasive micropapillary carcinoma
Distinct from in situ papillary carcinomas [solid papillary carcinoma, papillary DCIS, encapsulated papillary carcinoma (EPC)]
When these in situ processes have associated invasive component, invasive components usually display ductal, not papillary, features
IPC often has (papillary) DCIS in surrounding breast
IMAGING
General Features
Mammographic Findings
Ultrasonographic Findings
MR Findings
Image-Guided Biopsy
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Genetics
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Rakha EA et al: Diagnostic challenges in papillary lesions of the breast. Pathology. 50(1):100-110, 2018
Zheng YZ et al: Clinicopathological characteristics and survival outcomes in invasive papillary carcinoma of the breast: A SEER population-based study. Sci Rep. 6:24037, 2016
Tan PH et al: Papillary and neuroendocrine breast lesions: the WHO stance. Histopathology. 66(6):761-70, 2015
Kestelman FP et al: Imaging findings of papillary breast lesions: a pictorial review. Clin Radiol. 69(4):436-41, 2014
Eiada R et al: Papillary lesions of the breast: MRI, ultrasound, and mammographic appearances. AJR Am J Roentgenol. 198(2):264-71, 2012
Schnitt, SJ et al: WHO Classification of Tumours of the Breast. Lyon: International Agency for Research on Cancer, 2012
Chang JM et al: Risk of carcinoma after subsequent excision of benign papilloma initially diagnosed with an ultrasound (US)-guided 14-gauge core needle biopsy: a prospective observational study. Eur Radiol. 20(5):1093-100, 2010
Linda A et al: Unusual malignant tumors of the breast: MRI features and pathologic correlation. Eur J Radiol. 75(2):178-84, 2010
Pal SK et al: Papillary carcinoma of the breast: an overview. Breast Cancer Res Treat. 122(3):637-45, 2010
Yoo JL et al: Can MR imaging contribute in characterizing well-circumscribed breast carcinomas? Radiographics. 30(6):1689-702, 2010
Tse GM et al: The role of immunohistochemistry in the differential diagnosis of papillary lesions of the breast. J Clin Pathol. 62(5):407-13, 2009
Brookes MJ et al: Radiological appearances of papillary breast lesions. Clin Radiol. 63(11):1265-73, 2008
Kim TH et al: Sonographic differentiation of benign and malignant papillary lesions of the breast. J Ultrasound Med. 27(1):75-82, 2008
Mercado CL et al: Papillary lesions of the breast at percutaneous core-needle biopsy. Radiology. 238(3):801-8, 2006
Carder PJ et al: Needle core biopsy can reliably distinguish between benign and malignant papillary lesions of the breast. Histopathology. 46(3):320-7, 2005
Hill CB et al: Myoepithelial cell staining patterns of papillary breast lesions: from intraductal papillomas to invasive papillary carcinomas. Am J Clin Pathol. 123(1):36-44, 2005
Nagi C et al: Epithelial displacement in breast lesions: a papillary phenomenon. Arch Pathol Lab Med. 129(11):1465-9, 2005
Putti TC et al: Breast pathology practice: most common problems in a consultation service. Histopathology. 47(5):445-57, 2005
Yang WT et al: Sonographic, mammographic, and histopathologic correlation of symptomatic ductal carcinoma in situ. AJR Am J Roentgenol. 182(1):101-10, 2004
Blaumeiser B et al: Invasive papillary carcinoma of the male breast. Eur Radiol. 12(9):2207-10, 2002
Hoda SA et al: Practical considerations in the pathologic diagnosis of needle core biopsies of breast. Am J Clin Pathol. 118(1):101-8, 2002
Renshaw AA: Predicting invasion in the excision specimen from breast core needle biopsy specimens with only ductal carcinoma in situ. Arch Pathol Lab Med. 126(1):39-41, 2002
Liberman L et al: Case 35: intracystic papillary carcinoma with invasion. Radiology. 219(3):781-4, 2001
Orel SG et al: MR imaging in patients with nipple discharge: initial experience. Radiology. 216(1):248-54, 2000
Philpotts LE et al: Uncommon high-risk lesions of the breast diagnosed at stereotactic core-needle biopsy: clinical importance. Radiology. 216(3):831-7, 2000
Liberman L et al: Percutaneous large-core biopsy of papillary breast lesions. AJR Am J Roentgenol. 172(2):331-7, 1999
McCulloch GL et al: Radiological features of papillary carcinoma of the breast. Clin Radiol. 52(11):865-8, 1997
Soo MS et al: Papillary carcinoma of the breast: imaging findings. AJR Am J Roentgenol. 164(2):321-6, 1995
Mitnick JS et al: Invasive papillary carcinoma of the breast: mammographic appearance. Radiology. 177(3):803-6, 1990
Tabár L et al: Galactography: the diagnostic procedure of choice for nipple discharge. Radiology. 149(1):31-8, 1983
KRAUS FT et al: The differential diagnosis of papillary tumors of the breast. Cancer. 15:444-55, 1962
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
Invasive papillary carcinoma (IPC)
Definitions
Invasive carcinoma with > 90% exclusively papillary architecture of papillae with fibrovascular cores and lacking myoepithelial layer
Distinct from invasive micropapillary carcinoma
Distinct from in situ papillary carcinomas [solid papillary carcinoma, papillary DCIS, encapsulated papillary carcinoma (EPC)]
When these in situ processes have associated invasive component, invasive components usually display ductal, not papillary, features
IPC often has (papillary) DCIS in surrounding breast
IMAGING
General Features
Mammographic Findings
Ultrasonographic Findings
MR Findings
Image-Guided Biopsy
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Genetics
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Rakha EA et al: Diagnostic challenges in papillary lesions of the breast. Pathology. 50(1):100-110, 2018
Zheng YZ et al: Clinicopathological characteristics and survival outcomes in invasive papillary carcinoma of the breast: A SEER population-based study. Sci Rep. 6:24037, 2016
Tan PH et al: Papillary and neuroendocrine breast lesions: the WHO stance. Histopathology. 66(6):761-70, 2015
Kestelman FP et al: Imaging findings of papillary breast lesions: a pictorial review. Clin Radiol. 69(4):436-41, 2014
Eiada R et al: Papillary lesions of the breast: MRI, ultrasound, and mammographic appearances. AJR Am J Roentgenol. 198(2):264-71, 2012
Schnitt, SJ et al: WHO Classification of Tumours of the Breast. Lyon: International Agency for Research on Cancer, 2012
Chang JM et al: Risk of carcinoma after subsequent excision of benign papilloma initially diagnosed with an ultrasound (US)-guided 14-gauge core needle biopsy: a prospective observational study. Eur Radiol. 20(5):1093-100, 2010
Linda A et al: Unusual malignant tumors of the breast: MRI features and pathologic correlation. Eur J Radiol. 75(2):178-84, 2010
Pal SK et al: Papillary carcinoma of the breast: an overview. Breast Cancer Res Treat. 122(3):637-45, 2010
Yoo JL et al: Can MR imaging contribute in characterizing well-circumscribed breast carcinomas? Radiographics. 30(6):1689-702, 2010
Tse GM et al: The role of immunohistochemistry in the differential diagnosis of papillary lesions of the breast. J Clin Pathol. 62(5):407-13, 2009
Brookes MJ et al: Radiological appearances of papillary breast lesions. Clin Radiol. 63(11):1265-73, 2008
Kim TH et al: Sonographic differentiation of benign and malignant papillary lesions of the breast. J Ultrasound Med. 27(1):75-82, 2008
Mercado CL et al: Papillary lesions of the breast at percutaneous core-needle biopsy. Radiology. 238(3):801-8, 2006
Carder PJ et al: Needle core biopsy can reliably distinguish between benign and malignant papillary lesions of the breast. Histopathology. 46(3):320-7, 2005
Hill CB et al: Myoepithelial cell staining patterns of papillary breast lesions: from intraductal papillomas to invasive papillary carcinomas. Am J Clin Pathol. 123(1):36-44, 2005
Nagi C et al: Epithelial displacement in breast lesions: a papillary phenomenon. Arch Pathol Lab Med. 129(11):1465-9, 2005
Putti TC et al: Breast pathology practice: most common problems in a consultation service. Histopathology. 47(5):445-57, 2005
Yang WT et al: Sonographic, mammographic, and histopathologic correlation of symptomatic ductal carcinoma in situ. AJR Am J Roentgenol. 182(1):101-10, 2004
Blaumeiser B et al: Invasive papillary carcinoma of the male breast. Eur Radiol. 12(9):2207-10, 2002
Hoda SA et al: Practical considerations in the pathologic diagnosis of needle core biopsies of breast. Am J Clin Pathol. 118(1):101-8, 2002
Renshaw AA: Predicting invasion in the excision specimen from breast core needle biopsy specimens with only ductal carcinoma in situ. Arch Pathol Lab Med. 126(1):39-41, 2002
Liberman L et al: Case 35: intracystic papillary carcinoma with invasion. Radiology. 219(3):781-4, 2001
Orel SG et al: MR imaging in patients with nipple discharge: initial experience. Radiology. 216(1):248-54, 2000
Philpotts LE et al: Uncommon high-risk lesions of the breast diagnosed at stereotactic core-needle biopsy: clinical importance. Radiology. 216(3):831-7, 2000
Liberman L et al: Percutaneous large-core biopsy of papillary breast lesions. AJR Am J Roentgenol. 172(2):331-7, 1999
McCulloch GL et al: Radiological features of papillary carcinoma of the breast. Clin Radiol. 52(11):865-8, 1997
Soo MS et al: Papillary carcinoma of the breast: imaging findings. AJR Am J Roentgenol. 164(2):321-6, 1995
Mitnick JS et al: Invasive papillary carcinoma of the breast: mammographic appearance. Radiology. 177(3):803-6, 1990
Tabár L et al: Galactography: the diagnostic procedure of choice for nipple discharge. Radiology. 149(1):31-8, 1983
KRAUS FT et al: The differential diagnosis of papillary tumors of the breast. Cancer. 15:444-55, 1962
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