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Paraganglioma
Phillip Young, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Synonyms

              • Pheochromocytoma, cardiac neuroendocrine tumor
            • Definitions

              • Tumors that arise from cardiac autonomic paraganglia
              • 90% benign, ~ 1/3 hormonally active

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Ultrasonographic Findings

                      • Nuclear Medicine Findings

                        • Imaging Recommendations

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              • Gross Pathologic & Surgical Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Image Interpretation Pearls

                                            • Reporting Tips

                                              Selected References

                                              1. Young PM et al: Computed tomography imaging of cardiac masses. Radiol Clin North Am. 57(1):75-84, 2019
                                              2. Romano S et al: Succinate dehydrogenase gene mutation with cardiac paraganglioma: multimodality imaging and pathological correlation. Eur Heart J. 38(23):1853-54, 2017
                                              3. Semionov A et al: Multimodality imaging of a cardiac paraganglioma. Radiol Case Rep. 11(4):277-81, 2016
                                              4. Khan MF et al: Cardiac paraganglioma: clinical presentation, diagnostic approach and factors affecting short and long-term outcomes. Int J Cardiol. 166(2):315-20, 2013
                                              5. Rajiah P et al: Computed tomography of cardiac and pericardiac masses. J Cardiovasc Comput Tomogr. 5(1):16-29, 2011
                                              6. Erickson D et al: Benign paragangliomas: clinical presentation and treatment outcomes in 236 patients. J Clin Endocrinol Metab. 86(11):5210-6, 2001
                                              7. Araoz PA et al: CT and MR imaging of benign primary cardiac neoplasms with echocardiographic correlation. Radiographics. 20(5):1303-19, 2000
                                              8. Grebenc ML et al: Primary cardiac and pericardial neoplasms: radiologic-pathologic correlation. RadioGraphics. 20: 1073-1103, 2000
                                              9. Hamilton BH et al: Intrapericardial paragangliomas (pheochromocytomas): imaging features. AJR Am J Roentgenol. 168(1):109-13, 1997
                                              10. Jeevanandam V et al: Surgical management of cardiac pheochromocytoma. Resection versus transplantation. Ann Surg. 221(4):415-9, 1995
                                              Related Anatomy
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                                              Related Differential Diagnoses
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                                              References
                                              Tables

                                              Tables

                                              KEY FACTS

                                              • Terminology

                                                • Imaging

                                                  • Top Differential Diagnoses

                                                    • Clinical Issues

                                                      • Diagnostic Checklist

                                                        TERMINOLOGY

                                                        • Synonyms

                                                          • Pheochromocytoma, cardiac neuroendocrine tumor
                                                        • Definitions

                                                          • Tumors that arise from cardiac autonomic paraganglia
                                                          • 90% benign, ~ 1/3 hormonally active

                                                        IMAGING

                                                        • General Features

                                                          • Radiographic Findings

                                                            • CT Findings

                                                              • MR Findings

                                                                • Ultrasonographic Findings

                                                                  • Nuclear Medicine Findings

                                                                    • Imaging Recommendations

                                                                      DIFFERENTIAL DIAGNOSIS

                                                                        PATHOLOGY

                                                                        • General Features

                                                                          • Gross Pathologic & Surgical Features

                                                                            CLINICAL ISSUES

                                                                            • Presentation

                                                                              • Demographics

                                                                                • Natural History & Prognosis

                                                                                  • Treatment

                                                                                    DIAGNOSTIC CHECKLIST

                                                                                    • Consider

                                                                                      • Image Interpretation Pearls

                                                                                        • Reporting Tips

                                                                                          Selected References

                                                                                          1. Young PM et al: Computed tomography imaging of cardiac masses. Radiol Clin North Am. 57(1):75-84, 2019
                                                                                          2. Romano S et al: Succinate dehydrogenase gene mutation with cardiac paraganglioma: multimodality imaging and pathological correlation. Eur Heart J. 38(23):1853-54, 2017
                                                                                          3. Semionov A et al: Multimodality imaging of a cardiac paraganglioma. Radiol Case Rep. 11(4):277-81, 2016
                                                                                          4. Khan MF et al: Cardiac paraganglioma: clinical presentation, diagnostic approach and factors affecting short and long-term outcomes. Int J Cardiol. 166(2):315-20, 2013
                                                                                          5. Rajiah P et al: Computed tomography of cardiac and pericardiac masses. J Cardiovasc Comput Tomogr. 5(1):16-29, 2011
                                                                                          6. Erickson D et al: Benign paragangliomas: clinical presentation and treatment outcomes in 236 patients. J Clin Endocrinol Metab. 86(11):5210-6, 2001
                                                                                          7. Araoz PA et al: CT and MR imaging of benign primary cardiac neoplasms with echocardiographic correlation. Radiographics. 20(5):1303-19, 2000
                                                                                          8. Grebenc ML et al: Primary cardiac and pericardial neoplasms: radiologic-pathologic correlation. RadioGraphics. 20: 1073-1103, 2000
                                                                                          9. Hamilton BH et al: Intrapericardial paragangliomas (pheochromocytomas): imaging features. AJR Am J Roentgenol. 168(1):109-13, 1997
                                                                                          10. Jeevanandam V et al: Surgical management of cardiac pheochromocytoma. Resection versus transplantation. Ann Surg. 221(4):415-9, 1995