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Parathyroid Carcinoma
Jaclyn Thiessen, MD; Luke N. Ledbetter, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Parathyroid carcinoma (PTCa)
              • Definitions

                • Low-grade malignancy arising from PT gland

              IMAGING

              • General Features

                • MR Findings

                  • Nuclear Medicine Findings

                    • Ultrasonographic Findings

                      • CT Findings

                        • Imaging Recommendations

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              • Staging, Grading, & Classification

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Image Interpretation Pearls

                                          • Reporting Tips

                                            Selected References

                                            1. Liu J et al: Role of ultrasound in the differentiation of parathyroid carcinoma and benign parathyroid lesions. Clin Radiol. 75(3):179-84, 2020
                                            2. Ferraro V et al: Current concepts in parathyroid carcinoma: a single centre experience. BMC Endocr Disord. 19(Suppl 1):46, 2019
                                            3. Yildiz S et al: MRI findings and utility of DWI in the evaluation of solid parathyroid lesions. Radiol Med. 124(5):360-7, 2019
                                            4. Christakis I et al: The diagnostic accuracy of neck ultrasound, 4D-computed tomographyand sestamibi imaging in parathyroid carcinoma. Eur J Radiol. 95:82-8, 2017
                                            5. Nam M et al: Differentiation of parathyroid carcinoma and adenoma by preoperative ultrasonography. Acta Radiol. 58(6):670-5, 2017
                                            6. Asare EA et al: Parathyroid carcinoma: an update on treatment outcomes and prognostic factors from the national cancer data base (NCDB). Ann Surg Oncol. 22(12):3390-5, 2015
                                            7. Sadler C et al: Parathyroid carcinoma in more than 1,000 patients: a population-level analysis. Surgery. 156(6):1622-9; discussion 1629-30, 2014
                                            8. Wei CH et al: Parathyroid carcinoma: update and guidelines for management. Curr Treat Options Oncol. 13(1):11-23, 2012
                                            9. Owen RP et al: Parathyroid carcinoma: a review. Head Neck. 33(3): 429-36, 2011
                                            10. Dudney WC et al: Parathyroid carcinoma. Otolaryngol Clin North Am. 43(2):441-53, xi, 2010
                                            11. Givi B et al: Parathyroid carcinoma. Clin Oncol (R Coll Radiol). 22(6):498-507, 2010
                                            12. Lee YS et al: Parathyroid carcinoma: a 16-year experience in a single institution. Endocr J.57(6):493-7, 2010
                                            13. Okamoto T et al: Parathyroid carcinoma: etiology, diagnosis, and treatment. World J Surg. 33(11):2343-54, 2009
                                            14. Fakhran S et al: Parathyroid imaging. Neuroimaging Clin N Am. 18(3):537-49, ix, 2008
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Pathology

                                                    • Clinical Issues

                                                      • Diagnostic Checklist

                                                        TERMINOLOGY

                                                        • Abbreviations

                                                          • Parathyroid carcinoma (PTCa)
                                                        • Definitions

                                                          • Low-grade malignancy arising from PT gland

                                                        IMAGING

                                                        • General Features

                                                          • MR Findings

                                                            • Nuclear Medicine Findings

                                                              • Ultrasonographic Findings

                                                                • CT Findings

                                                                  • Imaging Recommendations

                                                                    DIFFERENTIAL DIAGNOSIS

                                                                      PATHOLOGY

                                                                      • General Features

                                                                        • Staging, Grading, & Classification

                                                                          CLINICAL ISSUES

                                                                          • Presentation

                                                                            • Demographics

                                                                              • Natural History & Prognosis

                                                                                • Treatment

                                                                                  DIAGNOSTIC CHECKLIST

                                                                                  • Image Interpretation Pearls

                                                                                    • Reporting Tips

                                                                                      Selected References

                                                                                      1. Liu J et al: Role of ultrasound in the differentiation of parathyroid carcinoma and benign parathyroid lesions. Clin Radiol. 75(3):179-84, 2020
                                                                                      2. Ferraro V et al: Current concepts in parathyroid carcinoma: a single centre experience. BMC Endocr Disord. 19(Suppl 1):46, 2019
                                                                                      3. Yildiz S et al: MRI findings and utility of DWI in the evaluation of solid parathyroid lesions. Radiol Med. 124(5):360-7, 2019
                                                                                      4. Christakis I et al: The diagnostic accuracy of neck ultrasound, 4D-computed tomographyand sestamibi imaging in parathyroid carcinoma. Eur J Radiol. 95:82-8, 2017
                                                                                      5. Nam M et al: Differentiation of parathyroid carcinoma and adenoma by preoperative ultrasonography. Acta Radiol. 58(6):670-5, 2017
                                                                                      6. Asare EA et al: Parathyroid carcinoma: an update on treatment outcomes and prognostic factors from the national cancer data base (NCDB). Ann Surg Oncol. 22(12):3390-5, 2015
                                                                                      7. Sadler C et al: Parathyroid carcinoma in more than 1,000 patients: a population-level analysis. Surgery. 156(6):1622-9; discussion 1629-30, 2014
                                                                                      8. Wei CH et al: Parathyroid carcinoma: update and guidelines for management. Curr Treat Options Oncol. 13(1):11-23, 2012
                                                                                      9. Owen RP et al: Parathyroid carcinoma: a review. Head Neck. 33(3): 429-36, 2011
                                                                                      10. Dudney WC et al: Parathyroid carcinoma. Otolaryngol Clin North Am. 43(2):441-53, xi, 2010
                                                                                      11. Givi B et al: Parathyroid carcinoma. Clin Oncol (R Coll Radiol). 22(6):498-507, 2010
                                                                                      12. Lee YS et al: Parathyroid carcinoma: a 16-year experience in a single institution. Endocr J.57(6):493-7, 2010
                                                                                      13. Okamoto T et al: Parathyroid carcinoma: etiology, diagnosis, and treatment. World J Surg. 33(11):2343-54, 2009
                                                                                      14. Fakhran S et al: Parathyroid imaging. Neuroimaging Clin N Am. 18(3):537-49, ix, 2008