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Parathyroid Disorders
Miral D. Jhaveri, MD, MBA
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Definitions

              • CNS manifestations related to parathyroid hormone (PTH) metabolic abnormalities
                • 1° and 2° hyperparathyroidism (HPTH)
                • Hypoparathyroidism (HP)
                • Pseudohypoparathyroidism (PHP)
                • Pseudopseudohypoparathyroidism (PPHP)

            IMAGING

            • General Features

              • Imaging Recommendations

                • CT Findings

                  • MR Findings

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        CLINICAL ISSUES

                        • Presentation

                          • Treatment

                            DIAGNOSTIC CHECKLIST

                            • Consider

                              Selected References

                              1. Hakami Y et al: Hypoparathyroidism. Front Horm Res. 51:109-26, 2019
                              2. Bilezikian JP et al: Hyperparathyroidism. Lancet. 391(10116):168-78, 2018
                              3. de la Plaza Llamas R et al: Brain calcifications and primary hyperparathyroidism. Cir Esp. 94(1):e5-7, 2016
                              4. Bandeira F et al: Bone disease in primary hyperparathyroidism. Arq Bras Endocrinol Metabol. 58(5):553-61, 2014
                              5. Lachungpa T et al: Imaging features of primary hyperparathyroidism. BMJ Case Rep, 2014
                              6. Khalid S et al: Idiopathic hypoparathyroidism as a cause of extensive intracranial calcification. JBR-BTR. 95(3):176, 2012
                              7. Karimi M et al: Hypoparathyroidism and intracerebral calcification in patients with beta-thalassemia major. Eur J Radiol. 70(3):481-4, 2009
                              8. Kung B et al: Parathyroid carcinoma: a rare cause of primary hyperparathyroidism. Ear Nose Throat J. 88(9):E10-3, 2009
                              9. You JS et al: Intracranial bilateral symmetric calcification in hypoparathyroidism. Emerg Med J. 25(3):162, 2008
                              10. Uchino A et al: Manganese accumulation in the brain: MR imaging. Neuroradiology. 49(9):715-20, 2007
                              11. Kern M et al: Intracranial metastatic parathyroid carcinoma. Case report and review of the literature. J Neurosurg. 101(6):1065-9, 2004
                              12. Dorenbeck U et al: Tentorial and dural calcification with tertiary hyperparathyroidism: a rare entity in chronic renal failure. Eur Radiol. 12 Suppl 3:S11-3, 2002
                              13. Herrero Hernandez E et al: T1-weighted hyperintensity in basal ganglia at brain magnetic resonance imaging: are different pathologies sharing a common mechanism? Neurotoxicology. 23(6):669-74, 2002
                              Related Anatomy
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                              Related Differential Diagnoses
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                              References
                              Tables

                              Tables

                              KEY FACTS

                              • Terminology

                                • Imaging

                                  • Top Differential Diagnoses

                                    • Pathology

                                      • Clinical Issues

                                        TERMINOLOGY

                                        • Definitions

                                          • CNS manifestations related to parathyroid hormone (PTH) metabolic abnormalities
                                            • 1° and 2° hyperparathyroidism (HPTH)
                                            • Hypoparathyroidism (HP)
                                            • Pseudohypoparathyroidism (PHP)
                                            • Pseudopseudohypoparathyroidism (PPHP)

                                        IMAGING

                                        • General Features

                                          • Imaging Recommendations

                                            • CT Findings

                                              • MR Findings

                                                DIFFERENTIAL DIAGNOSIS

                                                  PATHOLOGY

                                                  • General Features

                                                    CLINICAL ISSUES

                                                    • Presentation

                                                      • Treatment

                                                        DIAGNOSTIC CHECKLIST

                                                        • Consider

                                                          Selected References

                                                          1. Hakami Y et al: Hypoparathyroidism. Front Horm Res. 51:109-26, 2019
                                                          2. Bilezikian JP et al: Hyperparathyroidism. Lancet. 391(10116):168-78, 2018
                                                          3. de la Plaza Llamas R et al: Brain calcifications and primary hyperparathyroidism. Cir Esp. 94(1):e5-7, 2016
                                                          4. Bandeira F et al: Bone disease in primary hyperparathyroidism. Arq Bras Endocrinol Metabol. 58(5):553-61, 2014
                                                          5. Lachungpa T et al: Imaging features of primary hyperparathyroidism. BMJ Case Rep, 2014
                                                          6. Khalid S et al: Idiopathic hypoparathyroidism as a cause of extensive intracranial calcification. JBR-BTR. 95(3):176, 2012
                                                          7. Karimi M et al: Hypoparathyroidism and intracerebral calcification in patients with beta-thalassemia major. Eur J Radiol. 70(3):481-4, 2009
                                                          8. Kung B et al: Parathyroid carcinoma: a rare cause of primary hyperparathyroidism. Ear Nose Throat J. 88(9):E10-3, 2009
                                                          9. You JS et al: Intracranial bilateral symmetric calcification in hypoparathyroidism. Emerg Med J. 25(3):162, 2008
                                                          10. Uchino A et al: Manganese accumulation in the brain: MR imaging. Neuroradiology. 49(9):715-20, 2007
                                                          11. Kern M et al: Intracranial metastatic parathyroid carcinoma. Case report and review of the literature. J Neurosurg. 101(6):1065-9, 2004
                                                          12. Dorenbeck U et al: Tentorial and dural calcification with tertiary hyperparathyroidism: a rare entity in chronic renal failure. Eur Radiol. 12 Suppl 3:S11-3, 2002
                                                          13. Herrero Hernandez E et al: T1-weighted hyperintensity in basal ganglia at brain magnetic resonance imaging: are different pathologies sharing a common mechanism? Neurotoxicology. 23(6):669-74, 2002