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Parkinson Disease
Akiva Mintz, MD, PhD, MHA, CFA
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        TERMINOLOGY

        • Abbreviations

          • Parkinson disease (PD)
        • Definitions

          • Chronic, progressive brain disorder characterized by loss of dopaminergic neurons that leads to tremors at rest, rigidity, slowed movements, and gait

        IMAGING

        • General Features

          • Imaging Recommendations

            • Artifacts and Quality Control

              DIFFERENTIAL DIAGNOSIS

                PATHOLOGY

                • General Features

                  CLINICAL ISSUES

                  • Presentation

                    • Demographics

                      DIAGNOSTIC CHECKLIST

                      • Image Interpretation Pearls

                        • Reporting Tips

                          Selected References

                          1. Broski SM et al: Structural and functional imaging in parkinsonian syndromes. Radiographics. 34(5):1273-92, 2014
                          2. Bajaj N et al: Clinical utility of dopamine transporter single photon emission CT (DaT-SPECT) with (123I) ioflupane in diagnosis of parkinsonian syndromes. J Neurol Neurosurg Psychiatry. 84(11):1288-95, 2013
                          3. Djang DS et al: SNM practice guideline for dopamine transporter imaging with 123I-ioflupane SPECT 1.0. J Nucl Med. 53(1):154-63, 2012
                          4. Brooks DJ: Imaging approaches to Parkinson disease. J Nucl Med. 51(4):596-609, 2010
                          5. Tang CC et al: Differential diagnosis of parkinsonism: a metabolic imaging study using pattern analysis. Lancet Neurol. 9(2):149-58, 2010
                          6. Booij J et al: Dopamine transporter imaging with [(123)I]FP-CIT SPECT: potential effects of drugs. Eur J Nucl Med Mol Imaging. 35(2):424-38, 2008
                          7. Eckert T et al: FDG PET in the differential diagnosis of parkinsonian disorders. Neuroimage. 26(3):912-21, 2005
                          8. Marek K et al: [123I.] Neurology. 57(11):2089-94, 2001
                          9. Seil FJ et al: Reorganization of organotypic cultures of mouse cerebellum exposed to cytosine arabinoside: a timed ultrastructural study. J Comp Neurol. 313(2):193-212, 1991
                          10. FDA prescribing information for DaTscan Website. http://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/022454sOrig1s000Lbl.pdf
                          Related Anatomy
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                          Related Differential Diagnoses
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                          References
                          Tables

                          Tables

                          KEY FACTS

                          • Terminology

                            • Imaging

                              • Top Differential Diagnoses

                                TERMINOLOGY

                                • Abbreviations

                                  • Parkinson disease (PD)
                                • Definitions

                                  • Chronic, progressive brain disorder characterized by loss of dopaminergic neurons that leads to tremors at rest, rigidity, slowed movements, and gait

                                IMAGING

                                • General Features

                                  • Imaging Recommendations

                                    • Artifacts and Quality Control

                                      DIFFERENTIAL DIAGNOSIS

                                        PATHOLOGY

                                        • General Features

                                          CLINICAL ISSUES

                                          • Presentation

                                            • Demographics

                                              DIAGNOSTIC CHECKLIST

                                              • Image Interpretation Pearls

                                                • Reporting Tips

                                                  Selected References

                                                  1. Broski SM et al: Structural and functional imaging in parkinsonian syndromes. Radiographics. 34(5):1273-92, 2014
                                                  2. Bajaj N et al: Clinical utility of dopamine transporter single photon emission CT (DaT-SPECT) with (123I) ioflupane in diagnosis of parkinsonian syndromes. J Neurol Neurosurg Psychiatry. 84(11):1288-95, 2013
                                                  3. Djang DS et al: SNM practice guideline for dopamine transporter imaging with 123I-ioflupane SPECT 1.0. J Nucl Med. 53(1):154-63, 2012
                                                  4. Brooks DJ: Imaging approaches to Parkinson disease. J Nucl Med. 51(4):596-609, 2010
                                                  5. Tang CC et al: Differential diagnosis of parkinsonism: a metabolic imaging study using pattern analysis. Lancet Neurol. 9(2):149-58, 2010
                                                  6. Booij J et al: Dopamine transporter imaging with [(123)I]FP-CIT SPECT: potential effects of drugs. Eur J Nucl Med Mol Imaging. 35(2):424-38, 2008
                                                  7. Eckert T et al: FDG PET in the differential diagnosis of parkinsonian disorders. Neuroimage. 26(3):912-21, 2005
                                                  8. Marek K et al: [123I.] Neurology. 57(11):2089-94, 2001
                                                  9. Seil FJ et al: Reorganization of organotypic cultures of mouse cerebellum exposed to cytosine arabinoside: a timed ultrastructural study. J Comp Neurol. 313(2):193-212, 1991
                                                  10. FDA prescribing information for DaTscan Website. http://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/022454sOrig1s000Lbl.pdf