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Parotid Acinic Cell Carcinoma
Bronwyn E. Hamilton, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Synonyms

                • Acinic cell carcinoma (AciCC)
                • Synonyms: Acinar cell carcinoma, acinous cell carcinoma
              • Definitions

                • Slow-growing variant of adenocarcinoma arising in parotid glandular tissue
                • 3rd most frequent primary parotid malignancy after mucoepidermoid and adenoid cystic carcinoma

              IMAGING

              • General Features

                • CT Findings

                  • MR Findings

                    • Nuclear Medicine Findings

                      • Ultrasonographic Findings

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Staging, Grading, & Classification

                              • Gross Pathologic & Surgical Features

                                • Microscopic Features

                                  CLINICAL ISSUES

                                  • Presentation

                                    • Demographics

                                      • Natural History & Prognosis

                                        • Treatment

                                          DIAGNOSTIC CHECKLIST

                                          • Consider

                                            • Image Interpretation Pearls

                                              Selected References

                                              1. Mamlouk MD et al: Paediatric parotid neoplasms: a 10 year retrospective imaging and pathology review of these rare tumours. Clin Radiol. 70(3):270-7, 2015
                                              2. Bavle RM et al: Solid blue dot tumour: minor salivary gland acinic cell carcinoma. BMJ Case Rep. 2014, 2014
                                              3. Li J et al: Ultrasound and computed tomography features of primary acinic cell carcinoma in the parotid gland: a retrospective study. Eur J Radiol. 83(7):1152-6, 2014
                                              4. Durand N et al: Synchronous bilateral acinic cell carcinoma of the parotid: when a tumor reveals another one. Eur Ann Otorhinolaryngol Head Neck Dis. 130(1):22-5, 2013
                                              5. Jia YL et al: Synchronous bilateral multifocal acinic cell carcinoma of parotid gland: case report and review of the literature. J Oral Maxillofac Surg. 70(10):e574-80, 2012
                                              6. Lei Y et al: Re-evaluating historic cohort of salivary acinic cell carcinoma with new diagnostic tools. Head Neck Pathol. 6(2):166-70, 2012
                                              7. Christe A et al: MR imaging of parotid tumors: typical lesion characteristics in MR imaging improve discrimination between benign and malignant disease. AJNR Am J Neuroradiol. 32(7):1202-7, 2011
                                              8. Skálová A et al: Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity. Am J Surg Pathol. 34(5):599-608, 2010
                                              9. Al-Zaher N et al: Acinic cell carcinoma of the salivary glands: a literature review. Hematol Oncol Stem Cell Ther. 2(1):259-64, 2009
                                              10. Gomez DR et al: Clinical and pathologic prognostic features in acinic cell carcinoma of the parotid gland. Cancer. 115(10):2128-37, 2009
                                              11. Lima RA et al: Clinical prognostic factors in malignant parotid gland tumors. Otolaryngol Head Neck Surg. 133(5):702-8, 2005
                                              12. Suh SI et al: Acinic cell carcinoma of the head and neck: radiologic-pathologic correlation. J Comput Assist Tomogr. 29(1):121-6, 2005
                                              13. Sakai O et al: Acinic cell Carcinoma of the parotid gland: CT and MRI. Neuroradiology. 38(7):675-9, 1996
                                              14. Batsakis JG et al: Histopathologic grading of salivary gland neoplasms: II. Acinic cell carcinomas. Ann Otol Rhinol Laryngol. 99(11):929-33, 1990
                                              Related Anatomy
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                                              Related Differential Diagnoses
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                                              References
                                              Tables

                                              Tables

                                              KEY FACTS

                                              • Terminology

                                                • Imaging

                                                  • Top Differential Diagnoses

                                                    • Pathology

                                                      • Clinical Issues

                                                        • Diagnostic Checklist

                                                          TERMINOLOGY

                                                          • Synonyms

                                                            • Acinic cell carcinoma (AciCC)
                                                            • Synonyms: Acinar cell carcinoma, acinous cell carcinoma
                                                          • Definitions

                                                            • Slow-growing variant of adenocarcinoma arising in parotid glandular tissue
                                                            • 3rd most frequent primary parotid malignancy after mucoepidermoid and adenoid cystic carcinoma

                                                          IMAGING

                                                          • General Features

                                                            • CT Findings

                                                              • MR Findings

                                                                • Nuclear Medicine Findings

                                                                  • Ultrasonographic Findings

                                                                    DIFFERENTIAL DIAGNOSIS

                                                                      PATHOLOGY

                                                                      • General Features

                                                                        • Staging, Grading, & Classification

                                                                          • Gross Pathologic & Surgical Features

                                                                            • Microscopic Features

                                                                              CLINICAL ISSUES

                                                                              • Presentation

                                                                                • Demographics

                                                                                  • Natural History & Prognosis

                                                                                    • Treatment

                                                                                      DIAGNOSTIC CHECKLIST

                                                                                      • Consider

                                                                                        • Image Interpretation Pearls

                                                                                          Selected References

                                                                                          1. Mamlouk MD et al: Paediatric parotid neoplasms: a 10 year retrospective imaging and pathology review of these rare tumours. Clin Radiol. 70(3):270-7, 2015
                                                                                          2. Bavle RM et al: Solid blue dot tumour: minor salivary gland acinic cell carcinoma. BMJ Case Rep. 2014, 2014
                                                                                          3. Li J et al: Ultrasound and computed tomography features of primary acinic cell carcinoma in the parotid gland: a retrospective study. Eur J Radiol. 83(7):1152-6, 2014
                                                                                          4. Durand N et al: Synchronous bilateral acinic cell carcinoma of the parotid: when a tumor reveals another one. Eur Ann Otorhinolaryngol Head Neck Dis. 130(1):22-5, 2013
                                                                                          5. Jia YL et al: Synchronous bilateral multifocal acinic cell carcinoma of parotid gland: case report and review of the literature. J Oral Maxillofac Surg. 70(10):e574-80, 2012
                                                                                          6. Lei Y et al: Re-evaluating historic cohort of salivary acinic cell carcinoma with new diagnostic tools. Head Neck Pathol. 6(2):166-70, 2012
                                                                                          7. Christe A et al: MR imaging of parotid tumors: typical lesion characteristics in MR imaging improve discrimination between benign and malignant disease. AJNR Am J Neuroradiol. 32(7):1202-7, 2011
                                                                                          8. Skálová A et al: Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity. Am J Surg Pathol. 34(5):599-608, 2010
                                                                                          9. Al-Zaher N et al: Acinic cell carcinoma of the salivary glands: a literature review. Hematol Oncol Stem Cell Ther. 2(1):259-64, 2009
                                                                                          10. Gomez DR et al: Clinical and pathologic prognostic features in acinic cell carcinoma of the parotid gland. Cancer. 115(10):2128-37, 2009
                                                                                          11. Lima RA et al: Clinical prognostic factors in malignant parotid gland tumors. Otolaryngol Head Neck Surg. 133(5):702-8, 2005
                                                                                          12. Suh SI et al: Acinic cell carcinoma of the head and neck: radiologic-pathologic correlation. J Comput Assist Tomogr. 29(1):121-6, 2005
                                                                                          13. Sakai O et al: Acinic cell Carcinoma of the parotid gland: CT and MRI. Neuroradiology. 38(7):675-9, 1996
                                                                                          14. Batsakis JG et al: Histopathologic grading of salivary gland neoplasms: II. Acinic cell carcinomas. Ann Otol Rhinol Laryngol. 99(11):929-33, 1990