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Parotid Acinic Cell Carcinoma
Carmen C. Cho, MBBS, FRCR; H. Y. Yuen, MBChB, FRCR; Anil T. Ahuja, MD, FRCR
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KEY FACTS

  • Imaging

    • Top Differential Diagnoses

      • Clinical Issues

        • Diagnostic Checklist

          TERMINOLOGY

          • Abbreviations

            • Acinic cell carcinoma (AciCC)
          • Synonyms

            • Acinic cell adenocarcinoma
            • Acinous cell carcinoma
          • Definitions

            • Malignant epithelial neoplasm of salivary glands in which neoplastic cells demonstrate acinar differentiation

          IMAGING

          • General Features

            • Ultrasonographic Findings

              • CT Findings

                • MR Findings

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • Staging, Grading, & Classification

                        • Gross Pathologic & Surgical Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Consider

                                      • Image Interpretation Pearls

                                        Selected References

                                        1. Vander Poorten V et al: Salivary acinic cell carcinoma: reappraisal and update. Eur Arch Otorhinolaryngol. 273(11):3511-3531, 2016
                                        2. Jia YL et al: Synchronous bilateral multifocal acinic cell carcinoma of parotid gland: case report and review of the literature. J Oral Maxillofac Surg. 70(10):e574-80, 2012
                                        3. Gomez DR et al: Clinical and pathologic prognostic features in acinic cell carcinoma of the parotid gland. Cancer. 115(10):2128-37, 2009
                                        4. Ellis G et al. Tumors of the Salivary Glands AFIP Atlas of Tumor Pathology: Series 4. American Registry of Pathology. 4th ed. 216-8, 2008
                                        5. Lee YY et al: Imaging of salivary gland tumours. Eur J Radiol. 66(3):419-36, 2008
                                        6. Yabuuchi H et al: Parotid gland tumors: can addition of diffusion-weighted MR imaging to dynamic contrast-enhanced MR imaging improve diagnostic accuracy in characterization? Radiology. 249(3):909-16, 2008
                                        7. Thoeny HC: Imaging of salivary gland tumours. Cancer Imaging. 7:52-62, 2007
                                        8. Suh SI et al: Acinic cell carcinoma of the head and neck: radiologic-pathologic correlation. J Comput Assist Tomogr. 29(1):121-6, 2005
                                        9. Federspil PA et al: [Acinic cell carcinomas of the parotid gland. A retrospective analysis.] HNO. 49(10):825-30, 2001
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Clinical Issues

                                              • Diagnostic Checklist

                                                TERMINOLOGY

                                                • Abbreviations

                                                  • Acinic cell carcinoma (AciCC)
                                                • Synonyms

                                                  • Acinic cell adenocarcinoma
                                                  • Acinous cell carcinoma
                                                • Definitions

                                                  • Malignant epithelial neoplasm of salivary glands in which neoplastic cells demonstrate acinar differentiation

                                                IMAGING

                                                • General Features

                                                  • Ultrasonographic Findings

                                                    • CT Findings

                                                      • MR Findings

                                                        • Imaging Recommendations

                                                          DIFFERENTIAL DIAGNOSIS

                                                            PATHOLOGY

                                                            • Staging, Grading, & Classification

                                                              • Gross Pathologic & Surgical Features

                                                                • Microscopic Features

                                                                  CLINICAL ISSUES

                                                                  • Presentation

                                                                    • Demographics

                                                                      • Natural History & Prognosis

                                                                        • Treatment

                                                                          DIAGNOSTIC CHECKLIST

                                                                          • Consider

                                                                            • Image Interpretation Pearls

                                                                              Selected References

                                                                              1. Vander Poorten V et al: Salivary acinic cell carcinoma: reappraisal and update. Eur Arch Otorhinolaryngol. 273(11):3511-3531, 2016
                                                                              2. Jia YL et al: Synchronous bilateral multifocal acinic cell carcinoma of parotid gland: case report and review of the literature. J Oral Maxillofac Surg. 70(10):e574-80, 2012
                                                                              3. Gomez DR et al: Clinical and pathologic prognostic features in acinic cell carcinoma of the parotid gland. Cancer. 115(10):2128-37, 2009
                                                                              4. Ellis G et al. Tumors of the Salivary Glands AFIP Atlas of Tumor Pathology: Series 4. American Registry of Pathology. 4th ed. 216-8, 2008
                                                                              5. Lee YY et al: Imaging of salivary gland tumours. Eur J Radiol. 66(3):419-36, 2008
                                                                              6. Yabuuchi H et al: Parotid gland tumors: can addition of diffusion-weighted MR imaging to dynamic contrast-enhanced MR imaging improve diagnostic accuracy in characterization? Radiology. 249(3):909-16, 2008
                                                                              7. Thoeny HC: Imaging of salivary gland tumours. Cancer Imaging. 7:52-62, 2007
                                                                              8. Suh SI et al: Acinic cell carcinoma of the head and neck: radiologic-pathologic correlation. J Comput Assist Tomogr. 29(1):121-6, 2005
                                                                              9. Federspil PA et al: [Acinic cell carcinomas of the parotid gland. A retrospective analysis.] HNO. 49(10):825-30, 2001