Slow-growing variant of adenocarcinoma arising in parotid
3rd most frequent primary parotid malignancy after mucoepidermoid and adenoid cystic carcinoma
IMAGING
General Features
CT Findings
MR Findings
Nuclear Medicine Findings
Ultrasonographic Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Ali SA et al: Predictors of distant metastasis in acinic cell carcinoma of the parotid gland. World J Clin Oncol. 11(1):11-9, 2020
Fang Q et al: Predictors of distant metastasis in parotid acinic cell carcinoma. BMC Cancer. 19(1):475, 2019
Grasl S et al: Nodal metastases in acinic cell carcinoma of the parotid gland. J Clin Med. 8(9), 2019
Janz TA et al: Are demographics associated with mucoepidermoid or acinic cell carcinoma parotid malignancies in children? World J Otorhinolaryngol Head Neck Surg. 5(4):222-227, 2019
Kuwabara H et al: Hemorrhage of MRI and Immunohistochemical Panels Distinguish Secretory Carcinoma From Acinic Cell Carcinoma. Laryngoscope Investig Otolaryngol. 3(4):268-274, 2018
Scherl C et al: Outcomes and prognostic factors for parotid acinic cell Carcinoma: A National Cancer Database study of 2362 cases. Oral Oncol. 82:53-60, 2018
Mamlouk MD et al: Paediatric parotid neoplasms: a 10 year retrospective imaging and pathology review of these rare tumours. Clin Radiol. 70(3):270-7, 2015
Bavle RM et al: Solid blue dot tumour: minor salivary gland acinic cell carcinoma. BMJ Case Rep. 2014, 2014
Li J et al: Ultrasound and computed tomography features of primary acinic cell carcinoma in the parotid gland: a retrospective study. Eur J Radiol. 83(7):1152-6, 2014
Durand N et al: Synchronous bilateral acinic cell carcinoma of the parotid: when a tumor reveals another one. Eur Ann Otorhinolaryngol Head Neck Dis. 130(1):22-5, 2013
Jia YL et al: Synchronous bilateral multifocal acinic cell carcinoma of parotid gland: case report and review of the literature. J Oral Maxillofac Surg. 70(10):e574-80, 2012
Lei Y et al: Re-evaluating historic cohort of salivary acinic cell carcinoma with new diagnostic tools. Head Neck Pathol. 6(2):166-70, 2012
Christe A et al: MR imaging of parotid tumors: typical lesion characteristics in MR imaging improve discrimination between benign and malignant disease. AJNR Am J Neuroradiol. 32(7):1202-7, 2011
Skálová A et al: Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity. Am J Surg Pathol. 34(5):599-608, 2010
Al-Zaher N et al: Acinic cell carcinoma of the salivary glands: a literature review. Hematol Oncol Stem Cell Ther. 2(1):259-64, 2009
Gomez DR et al: Clinical and pathologic prognostic features in acinic cell carcinoma of the parotid gland. Cancer. 115(10):2128-37, 2009
Lima RA et al: Clinical prognostic factors in malignant parotid gland tumors. Otolaryngol Head Neck Surg. 133(5):702-8, 2005
Suh SI et al: Acinic cell carcinoma of the head and neck: radiologic-pathologic correlation. J Comput Assist Tomogr. 29(1):121-6, 2005
Sakai O et al: Acinic cell Carcinoma of the parotid gland: CT and MRI. Neuroradiology. 38(7):675-9, 1996
Batsakis JG et al: Histopathologic grading of salivary gland neoplasms: II. Acinic cell carcinomas. Ann Otol Rhinol Laryngol. 99(11):929-33, 1990
Related Anatomy
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
Acinic cell carcinoma (AciCC)
Synonyms
Acinar cell carcinoma, acinous cell carcinoma
Definitions
Slow-growing variant of adenocarcinoma arising in parotid
3rd most frequent primary parotid malignancy after mucoepidermoid and adenoid cystic carcinoma
IMAGING
General Features
CT Findings
MR Findings
Nuclear Medicine Findings
Ultrasonographic Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Ali SA et al: Predictors of distant metastasis in acinic cell carcinoma of the parotid gland. World J Clin Oncol. 11(1):11-9, 2020
Fang Q et al: Predictors of distant metastasis in parotid acinic cell carcinoma. BMC Cancer. 19(1):475, 2019
Grasl S et al: Nodal metastases in acinic cell carcinoma of the parotid gland. J Clin Med. 8(9), 2019
Janz TA et al: Are demographics associated with mucoepidermoid or acinic cell carcinoma parotid malignancies in children? World J Otorhinolaryngol Head Neck Surg. 5(4):222-227, 2019
Kuwabara H et al: Hemorrhage of MRI and Immunohistochemical Panels Distinguish Secretory Carcinoma From Acinic Cell Carcinoma. Laryngoscope Investig Otolaryngol. 3(4):268-274, 2018
Scherl C et al: Outcomes and prognostic factors for parotid acinic cell Carcinoma: A National Cancer Database study of 2362 cases. Oral Oncol. 82:53-60, 2018
Mamlouk MD et al: Paediatric parotid neoplasms: a 10 year retrospective imaging and pathology review of these rare tumours. Clin Radiol. 70(3):270-7, 2015
Bavle RM et al: Solid blue dot tumour: minor salivary gland acinic cell carcinoma. BMJ Case Rep. 2014, 2014
Li J et al: Ultrasound and computed tomography features of primary acinic cell carcinoma in the parotid gland: a retrospective study. Eur J Radiol. 83(7):1152-6, 2014
Durand N et al: Synchronous bilateral acinic cell carcinoma of the parotid: when a tumor reveals another one. Eur Ann Otorhinolaryngol Head Neck Dis. 130(1):22-5, 2013
Jia YL et al: Synchronous bilateral multifocal acinic cell carcinoma of parotid gland: case report and review of the literature. J Oral Maxillofac Surg. 70(10):e574-80, 2012
Lei Y et al: Re-evaluating historic cohort of salivary acinic cell carcinoma with new diagnostic tools. Head Neck Pathol. 6(2):166-70, 2012
Christe A et al: MR imaging of parotid tumors: typical lesion characteristics in MR imaging improve discrimination between benign and malignant disease. AJNR Am J Neuroradiol. 32(7):1202-7, 2011
Skálová A et al: Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity. Am J Surg Pathol. 34(5):599-608, 2010
Al-Zaher N et al: Acinic cell carcinoma of the salivary glands: a literature review. Hematol Oncol Stem Cell Ther. 2(1):259-64, 2009
Gomez DR et al: Clinical and pathologic prognostic features in acinic cell carcinoma of the parotid gland. Cancer. 115(10):2128-37, 2009
Lima RA et al: Clinical prognostic factors in malignant parotid gland tumors. Otolaryngol Head Neck Surg. 133(5):702-8, 2005
Suh SI et al: Acinic cell carcinoma of the head and neck: radiologic-pathologic correlation. J Comput Assist Tomogr. 29(1):121-6, 2005
Sakai O et al: Acinic cell Carcinoma of the parotid gland: CT and MRI. Neuroradiology. 38(7):675-9, 1996
Batsakis JG et al: Histopathologic grading of salivary gland neoplasms: II. Acinic cell carcinomas. Ann Otol Rhinol Laryngol. 99(11):929-33, 1990
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