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Parotid Malignant Mixed Tumor
Bronwyn E. Hamilton, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Malignant mixed tumor (MMT)
          • Synonyms

            • Carcinoma ex pleomorphic adenoma
            • Carcinoma ex benign mixed tumor
          • Definitions

            • Malignant tumor arising within parotid benign mixed tumor (BMT)
            • 2 types of MMT
              • Carcinoma ex pleomorphic adenoma
                • Common MMT type
                • Consists of single malignant cell type
              • Carcinosarcoma (true MMT)
                • Consists of multiple malignant cell types
                • Very rare (< 70 cases in literature)

          IMAGING

          • General Features

            • MR Findings

              • Imaging Recommendations

                DIFFERENTIAL DIAGNOSIS

                  PATHOLOGY

                  • General Features

                    • Staging, Grading, & Classification

                      • Gross Pathologic & Surgical Features

                        CLINICAL ISSUES

                        • Presentation

                          • Demographics

                            • Natural History & Prognosis

                              • Treatment

                                DIAGNOSTIC CHECKLIST

                                • Image Interpretation Pearls

                                  Selected References

                                  1. Kashiwagi N et al: Carcinoma ex pleomorphic adenoma of the parotid gland. Acta Radiol. 53(3):303-6, 2012
                                  2. Lüers JC et al: Carcinoma ex pleomorphic adenoma of the parotid gland. Study and implications for diagnostics and therapy. Acta Oncol. 48(1):132-6, 2009
                                  3. Kato H et al: Carcinoma ex pleomorphic adenoma of the parotid gland: radiologic-pathologic correlation with MR imaging including diffusion-weighted imaging. AJNR Am J Neuroradiol. 29(5):865-7, 2008
                                  4. Zbären P et al: Carcinoma ex pleomorphic adenoma: diagnostic difficulty and outcome. Otolaryngol Head Neck Surg. 138(5):601-5, 2008
                                  5. Völker HU et al: True malignant mixed tumour (carcinosarcoma) of submandibular gland--a rare neoplasm of monoclonal origin? Histopathology. 50(6):795-8, 2007
                                  6. Fan KF et al: MRI findings of carcinosarcoma in the parotid gland. Oral Oncol. 42(3):323-6, 2006
                                  7. Fowler MH et al: Malignant mixed tumors of the salivary gland: a study of loss of heterozygosity in tumor suppressor genes. Mod Pathol. 19(3):350-5, 2006
                                  8. Sheedy SP et al: CNS metastases of carcinoma ex pleomorphic adenoma of the parotid gland. AJNR Am J Neuroradiol. 27(7):1483-5, 2006
                                  9. Tortoledo ME et al: Carcinomas ex pleomorphic adenoma and malignant mixed tumors. Histomorphologic indexes. Arch Otolaryngol. 110(3):172-6, 1984
                                  Related Anatomy
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                                  Related Differential Diagnoses
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                                  References
                                  Tables

                                  Tables

                                  KEY FACTS

                                  • Terminology

                                    • Imaging

                                      • Top Differential Diagnoses

                                        • Clinical Issues

                                          TERMINOLOGY

                                          • Abbreviations

                                            • Malignant mixed tumor (MMT)
                                          • Synonyms

                                            • Carcinoma ex pleomorphic adenoma
                                            • Carcinoma ex benign mixed tumor
                                          • Definitions

                                            • Malignant tumor arising within parotid benign mixed tumor (BMT)
                                            • 2 types of MMT
                                              • Carcinoma ex pleomorphic adenoma
                                                • Common MMT type
                                                • Consists of single malignant cell type
                                              • Carcinosarcoma (true MMT)
                                                • Consists of multiple malignant cell types
                                                • Very rare (< 70 cases in literature)

                                          IMAGING

                                          • General Features

                                            • MR Findings

                                              • Imaging Recommendations

                                                DIFFERENTIAL DIAGNOSIS

                                                  PATHOLOGY

                                                  • General Features

                                                    • Staging, Grading, & Classification

                                                      • Gross Pathologic & Surgical Features

                                                        CLINICAL ISSUES

                                                        • Presentation

                                                          • Demographics

                                                            • Natural History & Prognosis

                                                              • Treatment

                                                                DIAGNOSTIC CHECKLIST

                                                                • Image Interpretation Pearls

                                                                  Selected References

                                                                  1. Kashiwagi N et al: Carcinoma ex pleomorphic adenoma of the parotid gland. Acta Radiol. 53(3):303-6, 2012
                                                                  2. Lüers JC et al: Carcinoma ex pleomorphic adenoma of the parotid gland. Study and implications for diagnostics and therapy. Acta Oncol. 48(1):132-6, 2009
                                                                  3. Kato H et al: Carcinoma ex pleomorphic adenoma of the parotid gland: radiologic-pathologic correlation with MR imaging including diffusion-weighted imaging. AJNR Am J Neuroradiol. 29(5):865-7, 2008
                                                                  4. Zbären P et al: Carcinoma ex pleomorphic adenoma: diagnostic difficulty and outcome. Otolaryngol Head Neck Surg. 138(5):601-5, 2008
                                                                  5. Völker HU et al: True malignant mixed tumour (carcinosarcoma) of submandibular gland--a rare neoplasm of monoclonal origin? Histopathology. 50(6):795-8, 2007
                                                                  6. Fan KF et al: MRI findings of carcinosarcoma in the parotid gland. Oral Oncol. 42(3):323-6, 2006
                                                                  7. Fowler MH et al: Malignant mixed tumors of the salivary gland: a study of loss of heterozygosity in tumor suppressor genes. Mod Pathol. 19(3):350-5, 2006
                                                                  8. Sheedy SP et al: CNS metastases of carcinoma ex pleomorphic adenoma of the parotid gland. AJNR Am J Neuroradiol. 27(7):1483-5, 2006
                                                                  9. Tortoledo ME et al: Carcinomas ex pleomorphic adenoma and malignant mixed tumors. Histomorphologic indexes. Arch Otolaryngol. 110(3):172-6, 1984