Malignant tumor arising within parotid benign mixed tumor (BMT)
2 types of MMT
Carcinoma ex pleomorphic adenoma
Common MMT type
Consists of single malignant cell type
Carcinosarcoma (true MMT)
Consists of multiple malignant cell types
Very rare (< 70 cases in literature)
IMAGING
General Features
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
Okano K et al: Cytological features of carcinoma ex pleomorphic adenoma of the salivary glands: a diagnostic challenge. Diagn Cytopathol. 48(2):149-53, 2020
Gupta A et al: Carcinoma ex pleomorphic adenoma: a review of incidence, demographics, risk factors, and survival. Am J Otolaryngol. 40(6):102279, 2019
Rauso R et al: Ossified Carcinoma Ex Pleomorphic Adenoma in accessory lobe of parotid gland: Complexity in clinical, imaging and histologic diagnosis and minimally invasive surgery. Oral Oncol. 92:95-98, 2019
Seok J et al: The Difference in the Clinical Features Between Carcinoma ex Pleomorphic Adenoma and Pleomorphic Adenoma. Ear Nose Throat J. 98(8):504-509, 2019
Covinsky M et al: Low Grade Carcinoma Ex-Pleomorphic Adenoma: Diagnosis and Diagnostic Challenges Caused by Fine Needle Aspiration: Report of Three Cases and Review of Literature. Head Neck Pathol. 12(1):82-88, 2018
Ogawa T et al: Clinical utility of dynamic-enhanced MRI in salivary gland tumors: retrospective study and literature review. Eur Arch Otorhinolaryngol. 275(6):1613-1621, 2018
Katayama I et al: Perfusion MR imaging detection of carcinoma arising from preexisting salivary gland pleomorphic adenoma by computer-assisted analysis of time-signal intensity maps. PLoS One. 12(5):e0178002, 2017
Kashiwagi N et al: Carcinoma ex pleomorphic adenoma of the parotid gland. Acta Radiol. 53(3):303-6, 2012
Katabi N et al: Prognostic factors of recurrence in salivary carcinoma ex pleomorphic adenoma, with emphasis on the carcinoma histologic subtype: a clinicopathologic study of 43 cases. Hum Pathol. Epub ahead of print, 2010
Lüers JC et al: Carcinoma ex pleomorphic adenoma of the parotid gland. Study and implications for diagnostics and therapy. Acta Oncol. 48(1):132-6, 2009
Kato H et al: Carcinoma ex pleomorphic adenoma of the parotid gland: radiologic-pathologic correlation with MR imaging including diffusion-weighted imaging. AJNR Am J Neuroradiol. 29(5):865-7, 2008
Zbären P et al: Carcinoma ex pleomorphic adenoma: diagnostic difficulty and outcome. Otolaryngol Head Neck Surg. 138(5):601-5, 2008
Völker HU et al: True malignant mixed tumour (carcinosarcoma) of submandibular gland--a rare neoplasm of monoclonal origin? Histopathology. 50(6):795-8, 2007
Fan KF et al: MRI findings of carcinosarcoma in the parotid gland. Oral Oncol. 42(3):323-6, 2006
Fowler MH et al: Malignant mixed tumors of the salivary gland: a study of loss of heterozygosity in tumor suppressor genes. Mod Pathol. 19(3):350-5, 2006
Sheedy SP et al: CNS metastases of carcinoma ex pleomorphic adenoma of the parotid gland. AJNR Am J Neuroradiol. 27(7):1483-5, 2006
Tortoledo ME et al: Carcinomas ex pleomorphic adenoma and malignant mixed tumors. Histomorphologic indexes. Arch Otolaryngol. 110(3):172-6, 1984
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
TERMINOLOGY
Abbreviations
Malignant mixed tumor (MMT)
Synonyms
Carcinoma ex pleomorphic adenoma
Carcinoma ex benign mixed tumor
Definitions
Malignant tumor arising within parotid benign mixed tumor (BMT)
2 types of MMT
Carcinoma ex pleomorphic adenoma
Common MMT type
Consists of single malignant cell type
Carcinosarcoma (true MMT)
Consists of multiple malignant cell types
Very rare (< 70 cases in literature)
IMAGING
General Features
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
Okano K et al: Cytological features of carcinoma ex pleomorphic adenoma of the salivary glands: a diagnostic challenge. Diagn Cytopathol. 48(2):149-53, 2020
Gupta A et al: Carcinoma ex pleomorphic adenoma: a review of incidence, demographics, risk factors, and survival. Am J Otolaryngol. 40(6):102279, 2019
Rauso R et al: Ossified Carcinoma Ex Pleomorphic Adenoma in accessory lobe of parotid gland: Complexity in clinical, imaging and histologic diagnosis and minimally invasive surgery. Oral Oncol. 92:95-98, 2019
Seok J et al: The Difference in the Clinical Features Between Carcinoma ex Pleomorphic Adenoma and Pleomorphic Adenoma. Ear Nose Throat J. 98(8):504-509, 2019
Covinsky M et al: Low Grade Carcinoma Ex-Pleomorphic Adenoma: Diagnosis and Diagnostic Challenges Caused by Fine Needle Aspiration: Report of Three Cases and Review of Literature. Head Neck Pathol. 12(1):82-88, 2018
Ogawa T et al: Clinical utility of dynamic-enhanced MRI in salivary gland tumors: retrospective study and literature review. Eur Arch Otorhinolaryngol. 275(6):1613-1621, 2018
Katayama I et al: Perfusion MR imaging detection of carcinoma arising from preexisting salivary gland pleomorphic adenoma by computer-assisted analysis of time-signal intensity maps. PLoS One. 12(5):e0178002, 2017
Kashiwagi N et al: Carcinoma ex pleomorphic adenoma of the parotid gland. Acta Radiol. 53(3):303-6, 2012
Katabi N et al: Prognostic factors of recurrence in salivary carcinoma ex pleomorphic adenoma, with emphasis on the carcinoma histologic subtype: a clinicopathologic study of 43 cases. Hum Pathol. Epub ahead of print, 2010
Lüers JC et al: Carcinoma ex pleomorphic adenoma of the parotid gland. Study and implications for diagnostics and therapy. Acta Oncol. 48(1):132-6, 2009
Kato H et al: Carcinoma ex pleomorphic adenoma of the parotid gland: radiologic-pathologic correlation with MR imaging including diffusion-weighted imaging. AJNR Am J Neuroradiol. 29(5):865-7, 2008
Zbären P et al: Carcinoma ex pleomorphic adenoma: diagnostic difficulty and outcome. Otolaryngol Head Neck Surg. 138(5):601-5, 2008
Völker HU et al: True malignant mixed tumour (carcinosarcoma) of submandibular gland--a rare neoplasm of monoclonal origin? Histopathology. 50(6):795-8, 2007
Fan KF et al: MRI findings of carcinosarcoma in the parotid gland. Oral Oncol. 42(3):323-6, 2006
Fowler MH et al: Malignant mixed tumors of the salivary gland: a study of loss of heterozygosity in tumor suppressor genes. Mod Pathol. 19(3):350-5, 2006
Sheedy SP et al: CNS metastases of carcinoma ex pleomorphic adenoma of the parotid gland. AJNR Am J Neuroradiol. 27(7):1483-5, 2006
Tortoledo ME et al: Carcinomas ex pleomorphic adenoma and malignant mixed tumors. Histomorphologic indexes. Arch Otolaryngol. 110(3):172-6, 1984
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