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Parotid Mucoepidermoid Carcinoma
Bronwyn E. Hamilton, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Mucoepidermoid carcinoma (MECa)
            • Definitions

              • Malignant epithelial salivary gland neoplasm composed of variable mixture of both epidermoid & mucus-secreting cells arising from ductal epithelium

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Nuclear Medicine Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Image Interpretation Pearls

                                            Selected References

                                            1. Mamlouk MD et al: Paediatric parotid neoplasms: a 10 year retrospective imaging and pathology review of these rare tumours. Clin Radiol. 70(3):270-7, 2015
                                            2. Gong X et al: Ultrasonographic appearances of mucoepidermoid carcinoma of the salivary glands. Oral Surg Oral Med Oral Pathol Oral Radiol. 114(3):382-7, 2012
                                            3. Kashiwagi N et al: MRI findings of mucoepidermoid carcinoma of the parotid gland: correlation with pathological features. Br J Radiol. 85(1014):709-13, 2012
                                            4. Singh Nanda KD et al: Fine-needle aspiration cytology: a reliable tool in the diagnosis of salivary gland lesions. J Oral Pathol Med. 41(1):106-12, 2012
                                            5. Christe A et al: MR imaging of parotid tumors: typical lesion characteristics in MR imaging improve discrimination between benign and malignant disease. AJNR Am J Neuroradiol. 32(7):1202-7, 2011
                                            6. Ashraf A et al: Diagnostic reliability of FNAC for salivary gland swellings: a comparative study. Diagn Cytopathol. 38(7):499-504, 2010
                                            7. Boukheris H et al: Incidence of carcinoma of the major salivary glands according to the WHO classification, 1992 to 2006: a population-based study in the United States. Cancer Epidemiol Biomarkers Prev. 18(11):2899-906, 2009
                                            8. Habermann CR et al: Diffusion-weighted echo-planar MR imaging of primary parotid gland tumors: is a prediction of different histologic subtypes possible? AJNR Am J Neuroradiol. 30(3):591-6, 2009
                                            9. Rapidis AD et al: Mucoepidermoid carcinoma of the salivary glands. Review of the literature and clinicopathological analysis of 18 patients. Oral Oncol. 43(2):130-6, 2007
                                            10. Pires FR et al: Prognostic factors in head and neck mucoepidermoid carcinoma. Arch Otolaryngol Head Neck Surg. 130(2):174-80, 2004
                                            11. Brachtel EF et al: Fine-needle aspiration biopsy of a cystic pleomorphic adenoma with extensive adnexa-like differentiation: differential diagnostic pitfall with mucoepidermoid carcinoma. Diagn Cytopathol. 28(2):100-3, 2003
                                            12. Catania A et al: Parotid gland tumours. Our experience and a review of the literature. Chir Ital. 55(6):857-64, 2003
                                            13. Nagao T et al: Dedifferentiation in low-grade mucoepidermoid carcinoma of the parotid gland. Hum Pathol. 34(10):1068-72, 2003
                                            14. Sakamoto M et al: Usefulness of heavily T(2) weighted magnetic resonance images for the differential diagnosis of parotid tumours. Dentomaxillofac Radiol. 32(5):295-9, 2003
                                            15. Wahlberg P et al: Carcinoma of the parotid and submandibular glands--a study of survival in 2465 patients. Oral Oncol. 38(7):706-13, 2002
                                            16. Brandwein MS et al: Mucoepidermoid carcinoma: a clinicopathologic study of 80 patients with special reference to histological grading. Am J Surg Pathol. 25(7):835-45, 2001
                                            17. Pinkston JA et al: Incidence rates of salivary gland tumors: results from a population-based study. Otolaryngol Head Neck Surg. 120(6):834-40, 1999
                                            18. Goode RK et al: Mucoepidermoid carcinoma of the major salivary glands: clinical and histopathologic analysis of 234 cases with evaluation of grading criteria. Cancer. 82(7):1217-24, 1998
                                            19. Schlakman BN et al: MR of intraparotid masses. AJNR Am J Neuroradiol. 14(5):1173-80, 1993
                                            20. Freling NJ et al: Malignant parotid tumors: clinical use of MR imaging and histologic correlation. Radiology. 185(3):691-6, 1992
                                            21. Som PM et al: High-grade malignancies of the parotid gland: identification with MR imaging. Radiology. 173(3):823-6, 1989
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Clinical Issues

                                                    • Diagnostic Checklist

                                                      TERMINOLOGY

                                                      • Abbreviations

                                                        • Mucoepidermoid carcinoma (MECa)
                                                      • Definitions

                                                        • Malignant epithelial salivary gland neoplasm composed of variable mixture of both epidermoid & mucus-secreting cells arising from ductal epithelium

                                                      IMAGING

                                                      • General Features

                                                        • CT Findings

                                                          • MR Findings

                                                            • Nuclear Medicine Findings

                                                              • Imaging Recommendations

                                                                DIFFERENTIAL DIAGNOSIS

                                                                  PATHOLOGY

                                                                  • General Features

                                                                    • Staging, Grading, & Classification

                                                                      • Gross Pathologic & Surgical Features

                                                                        • Microscopic Features

                                                                          CLINICAL ISSUES

                                                                          • Presentation

                                                                            • Demographics

                                                                              • Natural History & Prognosis

                                                                                • Treatment

                                                                                  DIAGNOSTIC CHECKLIST

                                                                                  • Consider

                                                                                    • Image Interpretation Pearls

                                                                                      Selected References

                                                                                      1. Mamlouk MD et al: Paediatric parotid neoplasms: a 10 year retrospective imaging and pathology review of these rare tumours. Clin Radiol. 70(3):270-7, 2015
                                                                                      2. Gong X et al: Ultrasonographic appearances of mucoepidermoid carcinoma of the salivary glands. Oral Surg Oral Med Oral Pathol Oral Radiol. 114(3):382-7, 2012
                                                                                      3. Kashiwagi N et al: MRI findings of mucoepidermoid carcinoma of the parotid gland: correlation with pathological features. Br J Radiol. 85(1014):709-13, 2012
                                                                                      4. Singh Nanda KD et al: Fine-needle aspiration cytology: a reliable tool in the diagnosis of salivary gland lesions. J Oral Pathol Med. 41(1):106-12, 2012
                                                                                      5. Christe A et al: MR imaging of parotid tumors: typical lesion characteristics in MR imaging improve discrimination between benign and malignant disease. AJNR Am J Neuroradiol. 32(7):1202-7, 2011
                                                                                      6. Ashraf A et al: Diagnostic reliability of FNAC for salivary gland swellings: a comparative study. Diagn Cytopathol. 38(7):499-504, 2010
                                                                                      7. Boukheris H et al: Incidence of carcinoma of the major salivary glands according to the WHO classification, 1992 to 2006: a population-based study in the United States. Cancer Epidemiol Biomarkers Prev. 18(11):2899-906, 2009
                                                                                      8. Habermann CR et al: Diffusion-weighted echo-planar MR imaging of primary parotid gland tumors: is a prediction of different histologic subtypes possible? AJNR Am J Neuroradiol. 30(3):591-6, 2009
                                                                                      9. Rapidis AD et al: Mucoepidermoid carcinoma of the salivary glands. Review of the literature and clinicopathological analysis of 18 patients. Oral Oncol. 43(2):130-6, 2007
                                                                                      10. Pires FR et al: Prognostic factors in head and neck mucoepidermoid carcinoma. Arch Otolaryngol Head Neck Surg. 130(2):174-80, 2004
                                                                                      11. Brachtel EF et al: Fine-needle aspiration biopsy of a cystic pleomorphic adenoma with extensive adnexa-like differentiation: differential diagnostic pitfall with mucoepidermoid carcinoma. Diagn Cytopathol. 28(2):100-3, 2003
                                                                                      12. Catania A et al: Parotid gland tumours. Our experience and a review of the literature. Chir Ital. 55(6):857-64, 2003
                                                                                      13. Nagao T et al: Dedifferentiation in low-grade mucoepidermoid carcinoma of the parotid gland. Hum Pathol. 34(10):1068-72, 2003
                                                                                      14. Sakamoto M et al: Usefulness of heavily T(2) weighted magnetic resonance images for the differential diagnosis of parotid tumours. Dentomaxillofac Radiol. 32(5):295-9, 2003
                                                                                      15. Wahlberg P et al: Carcinoma of the parotid and submandibular glands--a study of survival in 2465 patients. Oral Oncol. 38(7):706-13, 2002
                                                                                      16. Brandwein MS et al: Mucoepidermoid carcinoma: a clinicopathologic study of 80 patients with special reference to histological grading. Am J Surg Pathol. 25(7):835-45, 2001
                                                                                      17. Pinkston JA et al: Incidence rates of salivary gland tumors: results from a population-based study. Otolaryngol Head Neck Surg. 120(6):834-40, 1999
                                                                                      18. Goode RK et al: Mucoepidermoid carcinoma of the major salivary glands: clinical and histopathologic analysis of 234 cases with evaluation of grading criteria. Cancer. 82(7):1217-24, 1998
                                                                                      19. Schlakman BN et al: MR of intraparotid masses. AJNR Am J Neuroradiol. 14(5):1173-80, 1993
                                                                                      20. Freling NJ et al: Malignant parotid tumors: clinical use of MR imaging and histologic correlation. Radiology. 185(3):691-6, 1992
                                                                                      21. Som PM et al: High-grade malignancies of the parotid gland: identification with MR imaging. Radiology. 173(3):823-6, 1989