NHL includes any of various lymphomas, characterized by absence of Reed-Steinberg cells
Can be categorized into aggressive/high-grade or indolent/low-grade types
Formed by either B cells or T cells
Different forms of parotid involvement with NHL
Nodal NHL
Primary nodal NHL
Systemic NHL involving parotid nodes
Primary parenchymal lymphoma
Most often mucosa-associated lymphoid tissue (MALT)-type NHL (MALToma), often associated with Sjögren syndrome (SS) or benign lymphoepithelial lesion (BLEL)
IMAGING
General Features
Ultrasonographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Reporting Tips
Selected References
Swerdlow SH et al: The 2016 revision of the World Health Organization (WHO) classification of lymphoid neoplasms. Blood. ePub, 2016
Johnson SA et al: Imaging for staging and response assessment in lymphoma. Radiology. 276(2):323-38, 2015
Wyss E et al: Diagnosis and treatment outcomes for patients with lymphoma of the parotid gland. Laryngoscope. 123(3):662-9, 2013
Miyagi T et al: Extranodal adult T-cell leukemia/lymphoma of the head and neck: a clinicopathological study of nine cases and a review of the literature. Leuk Lymphoma. 50(2):187-95, 2009
Aiken AH et al: Imaging Hodgkin and non-Hodgkin lymphoma in the head and neck. Radiol Clin North Am. 46(2):363-78, ix-x, 2008
Just PA et al: 18F-fluorodeoxyglucose positron emission tomography/computed tomography in AIDS-related Burkitt lymphoma. AIDS Patient Care STDS. 22(9):695-700, 2008
Lee YY et al: Imaging of salivary gland tumours. Eur J Radiol. 66(3):419-36, 2008
Ando M et al: Mucosa-associated lymphoid tissue lymphoma presented as diffuse swelling of the parotid gland. Am J Otolaryngol. 26(4):285-8, 2005
Hew WS et al: Primary T cell lymphoma of salivary gland: a report of a case and review of the literature. J Clin Pathol. 55(1):61-3, 2002
Stein ME et al: Diagnosis and treatment of primary non-Hodgkin's lymphoma of the parotid gland: a retrospective study - Experience at the Northern Israel Oncology Center (1977-1999). J BUON. 7(3):229-33, 2002
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Imaging
Top Differential Diagnoses
Diagnostic Checklist
TERMINOLOGY
Abbreviations
Non-Hodgkin lymphoma (NHL)
Definitions
NHL includes any of various lymphomas, characterized by absence of Reed-Steinberg cells
Can be categorized into aggressive/high-grade or indolent/low-grade types
Formed by either B cells or T cells
Different forms of parotid involvement with NHL
Nodal NHL
Primary nodal NHL
Systemic NHL involving parotid nodes
Primary parenchymal lymphoma
Most often mucosa-associated lymphoid tissue (MALT)-type NHL (MALToma), often associated with Sjögren syndrome (SS) or benign lymphoepithelial lesion (BLEL)
IMAGING
General Features
Ultrasonographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Reporting Tips
Selected References
Swerdlow SH et al: The 2016 revision of the World Health Organization (WHO) classification of lymphoid neoplasms. Blood. ePub, 2016
Johnson SA et al: Imaging for staging and response assessment in lymphoma. Radiology. 276(2):323-38, 2015
Wyss E et al: Diagnosis and treatment outcomes for patients with lymphoma of the parotid gland. Laryngoscope. 123(3):662-9, 2013
Miyagi T et al: Extranodal adult T-cell leukemia/lymphoma of the head and neck: a clinicopathological study of nine cases and a review of the literature. Leuk Lymphoma. 50(2):187-95, 2009
Aiken AH et al: Imaging Hodgkin and non-Hodgkin lymphoma in the head and neck. Radiol Clin North Am. 46(2):363-78, ix-x, 2008
Just PA et al: 18F-fluorodeoxyglucose positron emission tomography/computed tomography in AIDS-related Burkitt lymphoma. AIDS Patient Care STDS. 22(9):695-700, 2008
Lee YY et al: Imaging of salivary gland tumours. Eur J Radiol. 66(3):419-36, 2008
Ando M et al: Mucosa-associated lymphoid tissue lymphoma presented as diffuse swelling of the parotid gland. Am J Otolaryngol. 26(4):285-8, 2005
Hew WS et al: Primary T cell lymphoma of salivary gland: a report of a case and review of the literature. J Clin Pathol. 55(1):61-3, 2002
Stein ME et al: Diagnosis and treatment of primary non-Hodgkin's lymphoma of the parotid gland: a retrospective study - Experience at the Northern Israel Oncology Center (1977-1999). J BUON. 7(3):229-33, 2002
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