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Parotid Non-Hodgkin Lymphoma
Bronwyn E. Hamilton, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Non-Hodgkin lymphoma (NHL)
              • Mucosa-associated lymphoid tissue (MALT) lymphoma
            • Definitions

              • 3 forms of parotid involvement with NHL
                • Nodal NHL
                  • Primary nodal NHL
                  • Systemic NHL involving parotid nodes
                • Primary parenchymal lymphoma
                  • Most often MALT-type NHL

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Ultrasonographic Findings

                    • Nuclear Medicine Findings

                      • Other Modality Findings

                        • Imaging Recommendations

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              • Staging, Grading, & Classification

                                • Gross Pathologic & Surgical Features

                                  • Microscopic Features

                                    CLINICAL ISSUES

                                    • Presentation

                                      • Demographics

                                        • Natural History & Prognosis

                                          • Treatment

                                            DIAGNOSTIC CHECKLIST

                                            • Consider

                                              • Image Interpretation Pearls

                                                Selected References

                                                1. Liang Y et al: Primary Sjogren's syndrome and malignancy risk: a systematic review and meta-analysis. Ann Rheum Dis. 73(6):1151-6, 2014
                                                2. Cohen C et al: 18F-fluorodeoxyglucose positron emission tomography/computer tomography as an objective tool for assessing disease activity in Sjögren's syndrome. Autoimmun Rev. 12(11):1109-14, 2013
                                                3. Feinstein AJ et al: Parotid gland lymphoma: prognostic analysis of 2140 patients. Laryngoscope. 123(5):1199-203, 2013
                                                4. Zhu L et al: Non-Hodgkin lymphoma involving the parotid gland: CT and MR imaging findings. Dentomaxillofac Radiol. 42(9):20130046, 2013
                                                5. Kato H et al: Mucosa-associated lymphoid tissue lymphoma of the salivary glands: MR imaging findings including diffusion-weighted imaging. Eur J Radiol. 81(4):e612-7, 2012
                                                6. Crampsey DP et al: Parotid lymphoma in west Scotland: two-year 'snapshot' of diagnosis, management and core issues. J Laryngol Otol. 123(11):1237-41, 2009
                                                7. Miyagi T et al: Extranodal adult T-cell leukemia/lymphoma of the head and neck: a clinicopathological study of nine cases and a review of the literature. Leuk Lymphoma. 50(2):187-95, 2009
                                                8. Aiken AH et al: Imaging Hodgkin and non-Hodgkin lymphoma in the head and neck. Radiol Clin North Am. 46(2):363-78, ix-x, 2008
                                                9. Just PA et al: 18F-fluorodeoxyglucose positron emission tomography/computed tomography in AIDS-related Burkitt lymphoma. AIDS Patient Care STDS. 22(9):695-700, 2008
                                                10. Ando M et al: Mucosa-associated lymphoid tissue lymphoma presented as diffuse swelling of the parotid gland. Am J Otolaryngol. 26(4):285-8, 2005
                                                11. Hafner JW et al: Childhood primary parotid non-Hodgkin's lymphoma with direct intracranial extension: a case report. Ear Nose Throat J. 83(12):828-30, 843, 2004
                                                12. Olivier KR et al: Efficacy and treatment-related toxicity of radiotherapy for early-stage primary non-Hodgkin lymphoma of the parotid gland. Int J Radiat Oncol Biol Phys. 60(5):1510-4, 2004
                                                13. Gasparotto D et al: Extrasalivary lymphoma development in Sjogren's syndrome: clonal evolution from parotid gland lymphoproliferation and role of local triggering. Arthritis Rheum. 48(11):3181-6, 2003
                                                14. Hamilton BE et al: Earring lesions of the parotid tail. AJNR Am J Neuroradiol. 24(9):1757-64, 2003
                                                15. Murga Penas EM et al: Translocations t(11;18)(q21;q21) and t(14;18)(q32;q21) are the main chromosomal abnormalities involving MLT/MALT1 in MALT lymphomas. Leukemia. 17(11):2225-9, 2003
                                                16. Zeebregts CJ et al: Synchronous tumours of the unilateral parotid gland: rare or undetected? J Craniomaxillofac Surg. 31(1):62-6, 2003
                                                17. Eichhorn KW et al: Malignant non-Hodgkin's lymphoma mimicking a benign parotid tumor: sonographic findings. J Clin Ultrasound. 30(1):42-4, 2002
                                                18. Hew WS et al: Primary T cell lymphoma of salivary gland: a report of a case and review of the literature. J Clin Pathol. 55(1):61-3, 2002
                                                19. Liao SL et al: Results of radiotherapy for orbital and adnexal lymphoma. Orbit. 21(2):117-23, 2002
                                                20. Stein ME et al: Diagnosis and treatment of primary non-Hodgkin's lymphoma of the parotid gland: a retrospective study - Experience at the Northern Israel Oncology Center (1977-1999). J BUON. 7(3):229-33, 2002
                                                21. Yencha MW: Primary parotid gland Hodgkin's lymphoma. Ann Otol Rhinol Laryngol. 111(4):338-42, 2002
                                                22. Abbondanzo SL: Extranodal marginal-zone B-cell lymphoma of the salivary gland. Ann Diagn Pathol. 5(4):246-54, 2001
                                                23. Epstein JB et al: Characteristics of oral and paraoral malignant lymphoma: a population-based review of 361 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 92(5):519-25, 2001
                                                24. Kojima M et al: Follicular lymphoma of the salivary gland: a clinicopathological and molecular study of six cases. Int J Surg Pathol. 9(4):287-93, 2001
                                                Related Anatomy
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                                                Related Differential Diagnoses
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                                                References
                                                Tables

                                                Tables

                                                KEY FACTS

                                                • Terminology

                                                  • Imaging

                                                    • Top Differential Diagnoses

                                                      • Clinical Issues

                                                        • Diagnostic Checklist

                                                          TERMINOLOGY

                                                          • Abbreviations

                                                            • Non-Hodgkin lymphoma (NHL)
                                                            • Mucosa-associated lymphoid tissue (MALT) lymphoma
                                                          • Definitions

                                                            • 3 forms of parotid involvement with NHL
                                                              • Nodal NHL
                                                                • Primary nodal NHL
                                                                • Systemic NHL involving parotid nodes
                                                              • Primary parenchymal lymphoma
                                                                • Most often MALT-type NHL

                                                          IMAGING

                                                          • General Features

                                                            • CT Findings

                                                              • MR Findings

                                                                • Ultrasonographic Findings

                                                                  • Nuclear Medicine Findings

                                                                    • Other Modality Findings

                                                                      • Imaging Recommendations

                                                                        DIFFERENTIAL DIAGNOSIS

                                                                          PATHOLOGY

                                                                          • General Features

                                                                            • Staging, Grading, & Classification

                                                                              • Gross Pathologic & Surgical Features

                                                                                • Microscopic Features

                                                                                  CLINICAL ISSUES

                                                                                  • Presentation

                                                                                    • Demographics

                                                                                      • Natural History & Prognosis

                                                                                        • Treatment

                                                                                          DIAGNOSTIC CHECKLIST

                                                                                          • Consider

                                                                                            • Image Interpretation Pearls

                                                                                              Selected References

                                                                                              1. Liang Y et al: Primary Sjogren's syndrome and malignancy risk: a systematic review and meta-analysis. Ann Rheum Dis. 73(6):1151-6, 2014
                                                                                              2. Cohen C et al: 18F-fluorodeoxyglucose positron emission tomography/computer tomography as an objective tool for assessing disease activity in Sjögren's syndrome. Autoimmun Rev. 12(11):1109-14, 2013
                                                                                              3. Feinstein AJ et al: Parotid gland lymphoma: prognostic analysis of 2140 patients. Laryngoscope. 123(5):1199-203, 2013
                                                                                              4. Zhu L et al: Non-Hodgkin lymphoma involving the parotid gland: CT and MR imaging findings. Dentomaxillofac Radiol. 42(9):20130046, 2013
                                                                                              5. Kato H et al: Mucosa-associated lymphoid tissue lymphoma of the salivary glands: MR imaging findings including diffusion-weighted imaging. Eur J Radiol. 81(4):e612-7, 2012
                                                                                              6. Crampsey DP et al: Parotid lymphoma in west Scotland: two-year 'snapshot' of diagnosis, management and core issues. J Laryngol Otol. 123(11):1237-41, 2009
                                                                                              7. Miyagi T et al: Extranodal adult T-cell leukemia/lymphoma of the head and neck: a clinicopathological study of nine cases and a review of the literature. Leuk Lymphoma. 50(2):187-95, 2009
                                                                                              8. Aiken AH et al: Imaging Hodgkin and non-Hodgkin lymphoma in the head and neck. Radiol Clin North Am. 46(2):363-78, ix-x, 2008
                                                                                              9. Just PA et al: 18F-fluorodeoxyglucose positron emission tomography/computed tomography in AIDS-related Burkitt lymphoma. AIDS Patient Care STDS. 22(9):695-700, 2008
                                                                                              10. Ando M et al: Mucosa-associated lymphoid tissue lymphoma presented as diffuse swelling of the parotid gland. Am J Otolaryngol. 26(4):285-8, 2005
                                                                                              11. Hafner JW et al: Childhood primary parotid non-Hodgkin's lymphoma with direct intracranial extension: a case report. Ear Nose Throat J. 83(12):828-30, 843, 2004
                                                                                              12. Olivier KR et al: Efficacy and treatment-related toxicity of radiotherapy for early-stage primary non-Hodgkin lymphoma of the parotid gland. Int J Radiat Oncol Biol Phys. 60(5):1510-4, 2004
                                                                                              13. Gasparotto D et al: Extrasalivary lymphoma development in Sjogren's syndrome: clonal evolution from parotid gland lymphoproliferation and role of local triggering. Arthritis Rheum. 48(11):3181-6, 2003
                                                                                              14. Hamilton BE et al: Earring lesions of the parotid tail. AJNR Am J Neuroradiol. 24(9):1757-64, 2003
                                                                                              15. Murga Penas EM et al: Translocations t(11;18)(q21;q21) and t(14;18)(q32;q21) are the main chromosomal abnormalities involving MLT/MALT1 in MALT lymphomas. Leukemia. 17(11):2225-9, 2003
                                                                                              16. Zeebregts CJ et al: Synchronous tumours of the unilateral parotid gland: rare or undetected? J Craniomaxillofac Surg. 31(1):62-6, 2003
                                                                                              17. Eichhorn KW et al: Malignant non-Hodgkin's lymphoma mimicking a benign parotid tumor: sonographic findings. J Clin Ultrasound. 30(1):42-4, 2002
                                                                                              18. Hew WS et al: Primary T cell lymphoma of salivary gland: a report of a case and review of the literature. J Clin Pathol. 55(1):61-3, 2002
                                                                                              19. Liao SL et al: Results of radiotherapy for orbital and adnexal lymphoma. Orbit. 21(2):117-23, 2002
                                                                                              20. Stein ME et al: Diagnosis and treatment of primary non-Hodgkin's lymphoma of the parotid gland: a retrospective study - Experience at the Northern Israel Oncology Center (1977-1999). J BUON. 7(3):229-33, 2002
                                                                                              21. Yencha MW: Primary parotid gland Hodgkin's lymphoma. Ann Otol Rhinol Laryngol. 111(4):338-42, 2002
                                                                                              22. Abbondanzo SL: Extranodal marginal-zone B-cell lymphoma of the salivary gland. Ann Diagn Pathol. 5(4):246-54, 2001
                                                                                              23. Epstein JB et al: Characteristics of oral and paraoral malignant lymphoma: a population-based review of 361 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 92(5):519-25, 2001
                                                                                              24. Kojima M et al: Follicular lymphoma of the salivary gland: a clinicopathological and molecular study of six cases. Int J Surg Pathol. 9(4):287-93, 2001