Rare, acquired stem cell disorder resulting in predisposition to complement-mediated hemolysis
IMAGING
General Features
CT Findings
MR Findings
Ultrasonographic Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
Alashkar F et al: The role of whole-body magnetic resonance imaging (WB-MRI) in patients with paroxysmal nocturnal hemoglobinuria (PNH). Sci Rep. 8(1):13458, 2018
Park C et al: Paroxysmal nocturnal hemoglobinuria: kidney biopsy and magnetic resonance imaging. Kidney Res Clin Pract. 37(1):96-7, 2018
De Cobelli F et al: New insights in abdominal pain in paroxysmal nocturnal hemoglobinuria (PNH): a MRI study. PLoS One. 10(4):e0122832, 2015
Van Bijnen ST et al: Mechanisms and clinical implications of thrombosis in paroxysmal nocturnal hemoglobinuria. J Thromb Haemost. 10(1):1-10, 2012
Jain P: An unusual cause of Budd-Chiari syndrome: paroxysmal nocturnal hemoglobinuria. J Gastrointestin Liver Dis. 19(1):107-8, 2010
Tufano A et al: Budd-Chiari syndrome in a paroxysmal nocturnal hemoglobinuria patient with previous cerebral venous thrombosis. Intern Emerg Med. 4(1):75-7, 2009
Nair RK et al: Spectrum of renal involvement in paroxysmal nocturnal hemoglobinuria: report of three cases and a brief review of the literature. Int Urol Nephrol. 40(2):471-5, 2008
Rimola J et al: The kidney in paroxysmal nocturnal haemoglobinuria: MRI findings. Br J Radiol. 77(923):953-6, 2004
Jeong JY et al: Atypical low-signal-intensity renal parenchyma: causes and patterns. Radiographics. 22(4):833-46, 2002
Titton RL et al: Case 51: paroxysmal nocturnal hemoglobinuria with thrombotic Budd-Chiari syndrome and renal cortical hemosiderin. Radiology. 225(1):67-70, 2002
Gayer G et al: Widespread abdominal venous thrombosis in paroxysmal nocturnal hemoglobinuria diagnosed on CT. Abdom Imaging. 26(4):414-9, 2001
Related Anatomy
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
Paroxysmal nocturnal hemoglobinuria (PNH)
Definitions
Rare, acquired stem cell disorder resulting in predisposition to complement-mediated hemolysis
IMAGING
General Features
CT Findings
MR Findings
Ultrasonographic Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
Alashkar F et al: The role of whole-body magnetic resonance imaging (WB-MRI) in patients with paroxysmal nocturnal hemoglobinuria (PNH). Sci Rep. 8(1):13458, 2018
Park C et al: Paroxysmal nocturnal hemoglobinuria: kidney biopsy and magnetic resonance imaging. Kidney Res Clin Pract. 37(1):96-7, 2018
De Cobelli F et al: New insights in abdominal pain in paroxysmal nocturnal hemoglobinuria (PNH): a MRI study. PLoS One. 10(4):e0122832, 2015
Van Bijnen ST et al: Mechanisms and clinical implications of thrombosis in paroxysmal nocturnal hemoglobinuria. J Thromb Haemost. 10(1):1-10, 2012
Jain P: An unusual cause of Budd-Chiari syndrome: paroxysmal nocturnal hemoglobinuria. J Gastrointestin Liver Dis. 19(1):107-8, 2010
Tufano A et al: Budd-Chiari syndrome in a paroxysmal nocturnal hemoglobinuria patient with previous cerebral venous thrombosis. Intern Emerg Med. 4(1):75-7, 2009
Nair RK et al: Spectrum of renal involvement in paroxysmal nocturnal hemoglobinuria: report of three cases and a brief review of the literature. Int Urol Nephrol. 40(2):471-5, 2008
Rimola J et al: The kidney in paroxysmal nocturnal haemoglobinuria: MRI findings. Br J Radiol. 77(923):953-6, 2004
Jeong JY et al: Atypical low-signal-intensity renal parenchyma: causes and patterns. Radiographics. 22(4):833-46, 2002
Titton RL et al: Case 51: paroxysmal nocturnal hemoglobinuria with thrombotic Budd-Chiari syndrome and renal cortical hemosiderin. Radiology. 225(1):67-70, 2002
Gayer G et al: Widespread abdominal venous thrombosis in paroxysmal nocturnal hemoglobinuria diagnosed on CT. Abdom Imaging. 26(4):414-9, 2001
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