Major clinical manifestation of fetal infection with parvovirus B19 is triad of anemia, heart failure, hydrops
IMAGING
General Features
Ultrasonographic Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Attwood LO et al: Identification and management of congenital parvovirus B19 infection. Prenat Diagn. 40(13):1722-31, 2020
Khalil A et al: ISUOG practice guidelines: role of ultrasound in congenital infection. Ultrasound Obstet Gynecol. 56(1):128-51, 2020
Sánchez-Durán MÁ et al: Perinatal outcomes and central nervous system abnormalities following intrauterine fetal transfusion: 17years' experience in a tertiary center. Transfusion. 60(11):2557-64, 2020
Manaresi E et al: Advances in the development of antiviral strategies against parvovirus B19. Viruses. 11(7), 2019
Martinez-Portilla RJ et al: Performance of fetal middle cerebral artery peak systolic velocity for prediction of anemia in untransfused and transfused fetuses: systematic review and meta-analysis. Ultrasound Obstet Gynecol. 54(6):722-31, 2019
Bascietto F et al: Outcome of fetuses with congenital parvovirus B19 infection: systematic review and meta-analysis. Ultrasound Obstet Gynecol. 52(5):569-76, 2018
American College of Obstetricians and Gynecologists: practice bulletin no. 151: cytomegalovirus, parvovirus B19, varicella zoster, and toxoplasmosis in pregnancy. Obstet Gynecol. 125(6):1510-25, 2015
Chen CC et al: Parvovirus B19 infection presenting with severe erythroid aplastic crisis during pregnancy in a woman with autoimmune hemolytic anemia and alpha-thalassemia trait: a case report. J Med Case Rep. 9:58, 2015
Ishikawa A et al: Quantitative analysis of human parvovirus B19 DNA in maternal and fetal serum, and amniotic fluid during an early stage of pregnancy. J Med Virol. 87(4):683-5, 2015
Melamed N et al: Fetal thrombocytopenia in pregnancies with fetal human parvovirus-B19 infection. Am J Obstet Gynecol. 212(6):793.e1-8, 2015
Crane J et al: Parvovirus B19 infection in pregnancy. J Obstet Gynaecol Can. 36(12):1107-16, 2014
Macé G et al: Clinical presentation and outcome of 20 fetuses with parvovirus B19 infection complicated by severe anemia and/or fetal hydrops. Prenat Diagn. 34(11):1023-30, 2014
Fishman SG et al: Parvovirus-mediated fetal cardiomyopathy with atrioventricular nodal disease. Pediatr Cardiol. 32(1):84-6, 2011
Enders M et al: Risk of fetal hydrops and non-hydropic late intrauterine fetal death after gestational parvovirus B19 infection. J Clin Virol. 49(3):163-8, 2010
Simms RA et al: Management and outcome of pregnancies with parvovirus B19 infection over seven years in a tertiary fetal medicine unit. Fetal Diagn Ther. 25(4):373-8, 2009
Related Anatomy
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Synonyms
B19V
Parvovirus, parvo
Definitions
Erythema infectiosum (fifth disease in children)
Major clinical manifestation of fetal infection with parvovirus B19 is triad of anemia, heart failure, hydrops
IMAGING
General Features
Ultrasonographic Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Attwood LO et al: Identification and management of congenital parvovirus B19 infection. Prenat Diagn. 40(13):1722-31, 2020
Khalil A et al: ISUOG practice guidelines: role of ultrasound in congenital infection. Ultrasound Obstet Gynecol. 56(1):128-51, 2020
Sánchez-Durán MÁ et al: Perinatal outcomes and central nervous system abnormalities following intrauterine fetal transfusion: 17years' experience in a tertiary center. Transfusion. 60(11):2557-64, 2020
Manaresi E et al: Advances in the development of antiviral strategies against parvovirus B19. Viruses. 11(7), 2019
Martinez-Portilla RJ et al: Performance of fetal middle cerebral artery peak systolic velocity for prediction of anemia in untransfused and transfused fetuses: systematic review and meta-analysis. Ultrasound Obstet Gynecol. 54(6):722-31, 2019
Bascietto F et al: Outcome of fetuses with congenital parvovirus B19 infection: systematic review and meta-analysis. Ultrasound Obstet Gynecol. 52(5):569-76, 2018
American College of Obstetricians and Gynecologists: practice bulletin no. 151: cytomegalovirus, parvovirus B19, varicella zoster, and toxoplasmosis in pregnancy. Obstet Gynecol. 125(6):1510-25, 2015
Chen CC et al: Parvovirus B19 infection presenting with severe erythroid aplastic crisis during pregnancy in a woman with autoimmune hemolytic anemia and alpha-thalassemia trait: a case report. J Med Case Rep. 9:58, 2015
Ishikawa A et al: Quantitative analysis of human parvovirus B19 DNA in maternal and fetal serum, and amniotic fluid during an early stage of pregnancy. J Med Virol. 87(4):683-5, 2015
Melamed N et al: Fetal thrombocytopenia in pregnancies with fetal human parvovirus-B19 infection. Am J Obstet Gynecol. 212(6):793.e1-8, 2015
Crane J et al: Parvovirus B19 infection in pregnancy. J Obstet Gynaecol Can. 36(12):1107-16, 2014
Macé G et al: Clinical presentation and outcome of 20 fetuses with parvovirus B19 infection complicated by severe anemia and/or fetal hydrops. Prenat Diagn. 34(11):1023-30, 2014
Fishman SG et al: Parvovirus-mediated fetal cardiomyopathy with atrioventricular nodal disease. Pediatr Cardiol. 32(1):84-6, 2011
Enders M et al: Risk of fetal hydrops and non-hydropic late intrauterine fetal death after gestational parvovirus B19 infection. J Clin Virol. 49(3):163-8, 2010
Simms RA et al: Management and outcome of pregnancies with parvovirus B19 infection over seven years in a tertiary fetal medicine unit. Fetal Diagn Ther. 25(4):373-8, 2009
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