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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
Pseudoangiomatous stromal hyperplasia (PASH)
Definitions
Pseudoangiomatous hyperplasia of mammary stroma
Benign, myofibroblastic, hyperplastic process
Contains extensive anastomosing, empty, "pseudoangiomatous," slit-like spaces lined by fibroblasts, mimicking vascular channels but lacking any red blood cells
IMAGING
General Features
Mammographic Findings
Ultrasonographic Findings
MR Findings
CT Findings
Nuclear Medicine Findings
Image-Guided Biopsy
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Canu GL et al: Pseudoangiomatous stromal hyperplasia (PASH) presenting as axillary lump: case report and review of the literature. G Chir. 39(6):378-382, 2018
Torous VF et al: Histopathologic findings in breast surgical specimens from patients undergoing female-to-male gender reassignment surgery. Mod Pathol. ePub, 2018
Whorms DS et al: Mesenchymal lesions of the breast: what radiologists need to know. AJR Am J Roentgenol. 211(1):224-233, 2018
Kelten Talu C et al: Pseudoangiomatous stromal hyperplasia in core needle biopsies of breast specimens. Int J Surg Pathol. 25(1):26-30, 2017
Kurt E et al: How to manage pseudoangiomatous stromal hyperplasia: our clinical experience Turk J Med Sci. 47(5):1410-1415, 2017
Raj SD et al: Pseudoangiomatous stromal hyperplasia of the breast: multimodality review with pathologic correlation. Curr Probl Diagn Radiol. 46(2):130-135, 2017
Protos A et al: Pseudoangiomatous Stromal Hyperplasia on Core Needle Biopsy Does Not Require Surgical Excision. Am Surg. 82(2):117-21, 2016
Bourke AG et al: Pseudoangiomatous stromal hyperplasia causing massive breast enlargement. BMJ Case Rep. 2015, 2015
Mizutou A et al: Large pseudoangiomatous stromal hyperplasia complicated with gynecomastia and lobular differentiation in a male breast. Springerplus. 4:282, 2015
Roy M et al: Pseudoangiomatous Stromal Hyperplasia: A Rare Cause of Idiopathic Gigantomastia. Plast Reconstr Surg Glob Open. 3(9):e501, 2015
Yılmaz E et al: Pseudoangiomatous stromal hyperplasia of the breast: mammosonography and elastography findings with a histopathological correlation. J Breast Health. 11(3):148-151, 2015
Bowman E et al: Pseudoangiomatous stromal hyperplasia (PASH) of the breast: a series of 24 patients. Breast J. 18(3):242-7, 2012
Celliers L et al: Pseudoangiomatous stromal hyperplasia: a study of the mammographic and sonographic features. Clin Radiol. 65(2):145-9, 2010
Degnim AC et al: Pseudoangiomatous stromal hyperplasia and breast cancer risk. Ann Surg Oncol. 17(12):3269-77, 2010
Gresik CM et al: Pseudoangiomatous stromal hyperplasia of the breast: a contemporary approach to its clinical and radiologic features and ideal management. Surgery. 148(4):752-7; discussion 757-8, 2010
Jones KN et al: Pseudoangiomatous stromal hyperplasia: imaging findings with pathologic and clinical correlation. AJR Am J Roentgenol. 195(4):1036-42, 2010
Ferreira M et al: Pseudoangiomatous stromal hyperplasia tumor: a clinical, radiologic and pathologic study of 26 cases. Mod Pathol. 21(2):201-7, 2008
Hargaden GC et al: Analysis of the mammographic and sonographic features of pseudoangiomatous stromal hyperplasia. AJR Am J Roentgenol. 191(2):359-63, 2008
Wieman SM et al: Tumoral pseudoangiomatous stromal hyperplasia of the breast. Am Surg. 74(12):1211-4, 2008
Leung JW et al: Developing asymmetry identified on mammography: correlation with imaging outcome and pathologic findings. AJR Am J Roentgenol. 188(3):667-75, 2007
Zúbor P et al: Rapidly growing nodular pseudoangiomatous stromal hyperplasia of the breast in an 18-year-old girl. APMIS. 114(5):389-92, 2006
Goel NB et al: Fibrous lesions of the breast: imaging-pathologic correlation. Radiographics. 25(6):1547-59, 2005
Mercado CL et al: Pseudoangiomatous stromal hyperplasia of the breast: sonographic features with histopathologic correlation. Breast J. 10(5):427-32, 2004
Moore T et al: Expression of CD34 and bcl-2 in phyllodes tumours, fibroadenomas and spindle cell lesions of the breast. Histopathology. 38(1):62-7, 2001
Kirkpatrick UJ et al: Imaging appearances of pseudoangiomatous hyperplasia of mammary stroma. Clin Radiol. 55(7):576-8, 2000
Piccoli CW et al: Developing asymmetric breast tissue. Radiology. 211(1):111-7, 1999
Simsir A et al: Additional mimics of mucinous mammary carcinoma: fibroepithelial lesions. Am J Clin Pathol. 109(2):169-72, 1998
Vicandi B et al: Nodular pseudoangiomatous stromal hyperplasia of the breast. Cytologic features. Acta Cytol. 42(2):335-41, 1998
Zanella M et al: Pseudoangiomatous hyperplasia of the mammary stroma: true entity or phenotype? Pathol Res Pract. 194(8):535-40, 1998
Badve S et al: Pseudoangiomatous hyperplasia of male breast. Histopathology. 26(5):463-6, 1995
Anderson C et al: Immunocytochemical analysis of estrogen and progesterone receptors in benign stromal lesions of the breast. Evidence for hormonal etiology in pseudoangiomatous hyperplasia of mammary stroma. Am J Surg Pathol. 15(2):145-9, 1991
Ibrahim RE et al: Pseudoangiomatous hyperplasia of mammary stroma. Some observations regarding its clinicopathologic spectrum. Cancer. 63(6):1154-60, 1989
Vuitch MF et al: Pseudoangiomatous hyperplasia of mammary stroma. Hum Pathol. 17(2):185-91, 1986
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
Pseudoangiomatous stromal hyperplasia (PASH)
Definitions
Pseudoangiomatous hyperplasia of mammary stroma
Benign, myofibroblastic, hyperplastic process
Contains extensive anastomosing, empty, "pseudoangiomatous," slit-like spaces lined by fibroblasts, mimicking vascular channels but lacking any red blood cells
IMAGING
General Features
Mammographic Findings
Ultrasonographic Findings
MR Findings
CT Findings
Nuclear Medicine Findings
Image-Guided Biopsy
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Canu GL et al: Pseudoangiomatous stromal hyperplasia (PASH) presenting as axillary lump: case report and review of the literature. G Chir. 39(6):378-382, 2018
Torous VF et al: Histopathologic findings in breast surgical specimens from patients undergoing female-to-male gender reassignment surgery. Mod Pathol. ePub, 2018
Whorms DS et al: Mesenchymal lesions of the breast: what radiologists need to know. AJR Am J Roentgenol. 211(1):224-233, 2018
Kelten Talu C et al: Pseudoangiomatous stromal hyperplasia in core needle biopsies of breast specimens. Int J Surg Pathol. 25(1):26-30, 2017
Kurt E et al: How to manage pseudoangiomatous stromal hyperplasia: our clinical experience Turk J Med Sci. 47(5):1410-1415, 2017
Raj SD et al: Pseudoangiomatous stromal hyperplasia of the breast: multimodality review with pathologic correlation. Curr Probl Diagn Radiol. 46(2):130-135, 2017
Protos A et al: Pseudoangiomatous Stromal Hyperplasia on Core Needle Biopsy Does Not Require Surgical Excision. Am Surg. 82(2):117-21, 2016
Bourke AG et al: Pseudoangiomatous stromal hyperplasia causing massive breast enlargement. BMJ Case Rep. 2015, 2015
Mizutou A et al: Large pseudoangiomatous stromal hyperplasia complicated with gynecomastia and lobular differentiation in a male breast. Springerplus. 4:282, 2015
Roy M et al: Pseudoangiomatous Stromal Hyperplasia: A Rare Cause of Idiopathic Gigantomastia. Plast Reconstr Surg Glob Open. 3(9):e501, 2015
Yılmaz E et al: Pseudoangiomatous stromal hyperplasia of the breast: mammosonography and elastography findings with a histopathological correlation. J Breast Health. 11(3):148-151, 2015
Bowman E et al: Pseudoangiomatous stromal hyperplasia (PASH) of the breast: a series of 24 patients. Breast J. 18(3):242-7, 2012
Celliers L et al: Pseudoangiomatous stromal hyperplasia: a study of the mammographic and sonographic features. Clin Radiol. 65(2):145-9, 2010
Degnim AC et al: Pseudoangiomatous stromal hyperplasia and breast cancer risk. Ann Surg Oncol. 17(12):3269-77, 2010
Gresik CM et al: Pseudoangiomatous stromal hyperplasia of the breast: a contemporary approach to its clinical and radiologic features and ideal management. Surgery. 148(4):752-7; discussion 757-8, 2010
Jones KN et al: Pseudoangiomatous stromal hyperplasia: imaging findings with pathologic and clinical correlation. AJR Am J Roentgenol. 195(4):1036-42, 2010
Ferreira M et al: Pseudoangiomatous stromal hyperplasia tumor: a clinical, radiologic and pathologic study of 26 cases. Mod Pathol. 21(2):201-7, 2008
Hargaden GC et al: Analysis of the mammographic and sonographic features of pseudoangiomatous stromal hyperplasia. AJR Am J Roentgenol. 191(2):359-63, 2008
Wieman SM et al: Tumoral pseudoangiomatous stromal hyperplasia of the breast. Am Surg. 74(12):1211-4, 2008
Leung JW et al: Developing asymmetry identified on mammography: correlation with imaging outcome and pathologic findings. AJR Am J Roentgenol. 188(3):667-75, 2007
Zúbor P et al: Rapidly growing nodular pseudoangiomatous stromal hyperplasia of the breast in an 18-year-old girl. APMIS. 114(5):389-92, 2006
Goel NB et al: Fibrous lesions of the breast: imaging-pathologic correlation. Radiographics. 25(6):1547-59, 2005
Mercado CL et al: Pseudoangiomatous stromal hyperplasia of the breast: sonographic features with histopathologic correlation. Breast J. 10(5):427-32, 2004
Moore T et al: Expression of CD34 and bcl-2 in phyllodes tumours, fibroadenomas and spindle cell lesions of the breast. Histopathology. 38(1):62-7, 2001
Kirkpatrick UJ et al: Imaging appearances of pseudoangiomatous hyperplasia of mammary stroma. Clin Radiol. 55(7):576-8, 2000
Piccoli CW et al: Developing asymmetric breast tissue. Radiology. 211(1):111-7, 1999
Simsir A et al: Additional mimics of mucinous mammary carcinoma: fibroepithelial lesions. Am J Clin Pathol. 109(2):169-72, 1998
Vicandi B et al: Nodular pseudoangiomatous stromal hyperplasia of the breast. Cytologic features. Acta Cytol. 42(2):335-41, 1998
Zanella M et al: Pseudoangiomatous hyperplasia of the mammary stroma: true entity or phenotype? Pathol Res Pract. 194(8):535-40, 1998
Badve S et al: Pseudoangiomatous hyperplasia of male breast. Histopathology. 26(5):463-6, 1995
Anderson C et al: Immunocytochemical analysis of estrogen and progesterone receptors in benign stromal lesions of the breast. Evidence for hormonal etiology in pseudoangiomatous hyperplasia of mammary stroma. Am J Surg Pathol. 15(2):145-9, 1991
Ibrahim RE et al: Pseudoangiomatous hyperplasia of mammary stroma. Some observations regarding its clinicopathologic spectrum. Cancer. 63(6):1154-60, 1989
Vuitch MF et al: Pseudoangiomatous hyperplasia of mammary stroma. Hum Pathol. 17(2):185-91, 1986
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