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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
- Pseudoangiomatous stromal hyperplasia (PASH)
Definitions
- Pseudoangiomatous hyperplasia of mammary stroma
- Benign, myofibroblastic, hyperplastic process
- Contains extensive anastomosing, empty, "pseudoangiomatous," slit-like spaces lined by fibroblasts, mimicking vascular channels but lacking any red blood cells
- Pseudoangiomatous hyperplasia of mammary stroma
IMAGING
General Features
Mammographic Findings
Ultrasonographic Findings
MR Findings
CT Findings
Nuclear Medicine Findings
Image-Guided Biopsy
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Canu GL et al: Pseudoangiomatous stromal hyperplasia (PASH) presenting as axillary lump: case report and review of the literature. G Chir. 39(6):378-382, 2018
- Torous VF et al: Histopathologic findings in breast surgical specimens from patients undergoing female-to-male gender reassignment surgery. Mod Pathol. ePub, 2018
- Whorms DS et al: Mesenchymal lesions of the breast: what radiologists need to know. AJR Am J Roentgenol. 211(1):224-233, 2018
- Kelten Talu C et al: Pseudoangiomatous stromal hyperplasia in core needle biopsies of breast specimens. Int J Surg Pathol. 25(1):26-30, 2017
- Kurt E et al: How to manage pseudoangiomatous stromal hyperplasia: our clinical experience Turk J Med Sci. 47(5):1410-1415, 2017
- Raj SD et al: Pseudoangiomatous stromal hyperplasia of the breast: multimodality review with pathologic correlation. Curr Probl Diagn Radiol. 46(2):130-135, 2017
- Protos A et al: Pseudoangiomatous Stromal Hyperplasia on Core Needle Biopsy Does Not Require Surgical Excision. Am Surg. 82(2):117-21, 2016
- Bourke AG et al: Pseudoangiomatous stromal hyperplasia causing massive breast enlargement. BMJ Case Rep. 2015, 2015
- Mizutou A et al: Large pseudoangiomatous stromal hyperplasia complicated with gynecomastia and lobular differentiation in a male breast. Springerplus. 4:282, 2015
- Roy M et al: Pseudoangiomatous Stromal Hyperplasia: A Rare Cause of Idiopathic Gigantomastia. Plast Reconstr Surg Glob Open. 3(9):e501, 2015
- Yılmaz E et al: Pseudoangiomatous stromal hyperplasia of the breast: mammosonography and elastography findings with a histopathological correlation. J Breast Health. 11(3):148-151, 2015
- Bowman E et al: Pseudoangiomatous stromal hyperplasia (PASH) of the breast: a series of 24 patients. Breast J. 18(3):242-7, 2012
- Celliers L et al: Pseudoangiomatous stromal hyperplasia: a study of the mammographic and sonographic features. Clin Radiol. 65(2):145-9, 2010
- Degnim AC et al: Pseudoangiomatous stromal hyperplasia and breast cancer risk. Ann Surg Oncol. 17(12):3269-77, 2010
- Gresik CM et al: Pseudoangiomatous stromal hyperplasia of the breast: a contemporary approach to its clinical and radiologic features and ideal management. Surgery. 148(4):752-7; discussion 757-8, 2010
- Jones KN et al: Pseudoangiomatous stromal hyperplasia: imaging findings with pathologic and clinical correlation. AJR Am J Roentgenol. 195(4):1036-42, 2010
- Ferreira M et al: Pseudoangiomatous stromal hyperplasia tumor: a clinical, radiologic and pathologic study of 26 cases. Mod Pathol. 21(2):201-7, 2008
- Hargaden GC et al: Analysis of the mammographic and sonographic features of pseudoangiomatous stromal hyperplasia. AJR Am J Roentgenol. 191(2):359-63, 2008
- Wieman SM et al: Tumoral pseudoangiomatous stromal hyperplasia of the breast. Am Surg. 74(12):1211-4, 2008
- Leung JW et al: Developing asymmetry identified on mammography: correlation with imaging outcome and pathologic findings. AJR Am J Roentgenol. 188(3):667-75, 2007
- Zúbor P et al: Rapidly growing nodular pseudoangiomatous stromal hyperplasia of the breast in an 18-year-old girl. APMIS. 114(5):389-92, 2006
- Goel NB et al: Fibrous lesions of the breast: imaging-pathologic correlation. Radiographics. 25(6):1547-59, 2005
- Mercado CL et al: Pseudoangiomatous stromal hyperplasia of the breast: sonographic features with histopathologic correlation. Breast J. 10(5):427-32, 2004
- Moore T et al: Expression of CD34 and bcl-2 in phyllodes tumours, fibroadenomas and spindle cell lesions of the breast. Histopathology. 38(1):62-7, 2001
- Kirkpatrick UJ et al: Imaging appearances of pseudoangiomatous hyperplasia of mammary stroma. Clin Radiol. 55(7):576-8, 2000
- Piccoli CW et al: Developing asymmetric breast tissue. Radiology. 211(1):111-7, 1999
- Simsir A et al: Additional mimics of mucinous mammary carcinoma: fibroepithelial lesions. Am J Clin Pathol. 109(2):169-72, 1998
- Vicandi B et al: Nodular pseudoangiomatous stromal hyperplasia of the breast. Cytologic features. Acta Cytol. 42(2):335-41, 1998
- Zanella M et al: Pseudoangiomatous hyperplasia of the mammary stroma: true entity or phenotype? Pathol Res Pract. 194(8):535-40, 1998
- Badve S et al: Pseudoangiomatous hyperplasia of male breast. Histopathology. 26(5):463-6, 1995
- Anderson C et al: Immunocytochemical analysis of estrogen and progesterone receptors in benign stromal lesions of the breast. Evidence for hormonal etiology in pseudoangiomatous hyperplasia of mammary stroma. Am J Surg Pathol. 15(2):145-9, 1991
- Ibrahim RE et al: Pseudoangiomatous hyperplasia of mammary stroma. Some observations regarding its clinicopathologic spectrum. Cancer. 63(6):1154-60, 1989
- Vuitch MF et al: Pseudoangiomatous hyperplasia of mammary stroma. Hum Pathol. 17(2):185-91, 1986
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
- Pseudoangiomatous stromal hyperplasia (PASH)
Definitions
- Pseudoangiomatous hyperplasia of mammary stroma
- Benign, myofibroblastic, hyperplastic process
- Contains extensive anastomosing, empty, "pseudoangiomatous," slit-like spaces lined by fibroblasts, mimicking vascular channels but lacking any red blood cells
- Pseudoangiomatous hyperplasia of mammary stroma
IMAGING
General Features
Mammographic Findings
Ultrasonographic Findings
MR Findings
CT Findings
Nuclear Medicine Findings
Image-Guided Biopsy
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Canu GL et al: Pseudoangiomatous stromal hyperplasia (PASH) presenting as axillary lump: case report and review of the literature. G Chir. 39(6):378-382, 2018
- Torous VF et al: Histopathologic findings in breast surgical specimens from patients undergoing female-to-male gender reassignment surgery. Mod Pathol. ePub, 2018
- Whorms DS et al: Mesenchymal lesions of the breast: what radiologists need to know. AJR Am J Roentgenol. 211(1):224-233, 2018
- Kelten Talu C et al: Pseudoangiomatous stromal hyperplasia in core needle biopsies of breast specimens. Int J Surg Pathol. 25(1):26-30, 2017
- Kurt E et al: How to manage pseudoangiomatous stromal hyperplasia: our clinical experience Turk J Med Sci. 47(5):1410-1415, 2017
- Raj SD et al: Pseudoangiomatous stromal hyperplasia of the breast: multimodality review with pathologic correlation. Curr Probl Diagn Radiol. 46(2):130-135, 2017
- Protos A et al: Pseudoangiomatous Stromal Hyperplasia on Core Needle Biopsy Does Not Require Surgical Excision. Am Surg. 82(2):117-21, 2016
- Bourke AG et al: Pseudoangiomatous stromal hyperplasia causing massive breast enlargement. BMJ Case Rep. 2015, 2015
- Mizutou A et al: Large pseudoangiomatous stromal hyperplasia complicated with gynecomastia and lobular differentiation in a male breast. Springerplus. 4:282, 2015
- Roy M et al: Pseudoangiomatous Stromal Hyperplasia: A Rare Cause of Idiopathic Gigantomastia. Plast Reconstr Surg Glob Open. 3(9):e501, 2015
- Yılmaz E et al: Pseudoangiomatous stromal hyperplasia of the breast: mammosonography and elastography findings with a histopathological correlation. J Breast Health. 11(3):148-151, 2015
- Bowman E et al: Pseudoangiomatous stromal hyperplasia (PASH) of the breast: a series of 24 patients. Breast J. 18(3):242-7, 2012
- Celliers L et al: Pseudoangiomatous stromal hyperplasia: a study of the mammographic and sonographic features. Clin Radiol. 65(2):145-9, 2010
- Degnim AC et al: Pseudoangiomatous stromal hyperplasia and breast cancer risk. Ann Surg Oncol. 17(12):3269-77, 2010
- Gresik CM et al: Pseudoangiomatous stromal hyperplasia of the breast: a contemporary approach to its clinical and radiologic features and ideal management. Surgery. 148(4):752-7; discussion 757-8, 2010
- Jones KN et al: Pseudoangiomatous stromal hyperplasia: imaging findings with pathologic and clinical correlation. AJR Am J Roentgenol. 195(4):1036-42, 2010
- Ferreira M et al: Pseudoangiomatous stromal hyperplasia tumor: a clinical, radiologic and pathologic study of 26 cases. Mod Pathol. 21(2):201-7, 2008
- Hargaden GC et al: Analysis of the mammographic and sonographic features of pseudoangiomatous stromal hyperplasia. AJR Am J Roentgenol. 191(2):359-63, 2008
- Wieman SM et al: Tumoral pseudoangiomatous stromal hyperplasia of the breast. Am Surg. 74(12):1211-4, 2008
- Leung JW et al: Developing asymmetry identified on mammography: correlation with imaging outcome and pathologic findings. AJR Am J Roentgenol. 188(3):667-75, 2007
- Zúbor P et al: Rapidly growing nodular pseudoangiomatous stromal hyperplasia of the breast in an 18-year-old girl. APMIS. 114(5):389-92, 2006
- Goel NB et al: Fibrous lesions of the breast: imaging-pathologic correlation. Radiographics. 25(6):1547-59, 2005
- Mercado CL et al: Pseudoangiomatous stromal hyperplasia of the breast: sonographic features with histopathologic correlation. Breast J. 10(5):427-32, 2004
- Moore T et al: Expression of CD34 and bcl-2 in phyllodes tumours, fibroadenomas and spindle cell lesions of the breast. Histopathology. 38(1):62-7, 2001
- Kirkpatrick UJ et al: Imaging appearances of pseudoangiomatous hyperplasia of mammary stroma. Clin Radiol. 55(7):576-8, 2000
- Piccoli CW et al: Developing asymmetric breast tissue. Radiology. 211(1):111-7, 1999
- Simsir A et al: Additional mimics of mucinous mammary carcinoma: fibroepithelial lesions. Am J Clin Pathol. 109(2):169-72, 1998
- Vicandi B et al: Nodular pseudoangiomatous stromal hyperplasia of the breast. Cytologic features. Acta Cytol. 42(2):335-41, 1998
- Zanella M et al: Pseudoangiomatous hyperplasia of the mammary stroma: true entity or phenotype? Pathol Res Pract. 194(8):535-40, 1998
- Badve S et al: Pseudoangiomatous hyperplasia of male breast. Histopathology. 26(5):463-6, 1995
- Anderson C et al: Immunocytochemical analysis of estrogen and progesterone receptors in benign stromal lesions of the breast. Evidence for hormonal etiology in pseudoangiomatous hyperplasia of mammary stroma. Am J Surg Pathol. 15(2):145-9, 1991
- Ibrahim RE et al: Pseudoangiomatous hyperplasia of mammary stroma. Some observations regarding its clinicopathologic spectrum. Cancer. 63(6):1154-60, 1989
- Vuitch MF et al: Pseudoangiomatous hyperplasia of mammary stroma. Hum Pathol. 17(2):185-91, 1986
