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Pediatric Lymphoma
Andrew T. Trout, MD
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KEY FACTS

  • Imaging

    • Top Differential Diagnoses

      • Pathology

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Definitions

              • Malignancy derived from cells of immune system

            IMAGING

            • F-18 FDG PET and PET/CT Findings

              • PET/MR Findings

                • General Features

                  • CT Findings

                    • MR Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Staging, Grading, & Classification

                              • Gross Pathologic & Surgical Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Image Interpretation Pearls

                                          • Reporting Tips

                                            Selected References

                                            1. Albano D et al: Comparison between whole-body MRI with diffusion-weighted imaging and PET/CT in staging newly diagnosed FDG-avid lymphomas. Eur J Radiol. 85(2):313-8, 2016
                                            2. Kluge R et al: Inter-Reader Reliability of Early FDG-PET/CT Response Assessment Using the Deauville Scale after 2 Cycles of Intensive Chemotherapy (OEPA) in Hodgkin's Lymphoma. PLoS One. 11(3):e0149072, 2016
                                            3. Sher AC et al: Assessment of Sequential PET/MRI in Comparison With PET/CT of Pediatric Lymphoma: A Prospective Study. AJR Am J Roentgenol. 206(3):623-31, 2016
                                            4. Bhojwani D et al: The role of FDG-PET/CT in the evaluation of residual disease in paediatric non-Hodgkin lymphoma. Br J Haematol. 168(6):845-53, 2015
                                            5. Chen-Liang TH et al: The role of bone marrow biopsy and FDG-PET/CT in identifying bone marrow infiltration in the initial diagnosis of high grade non-Hodgkin B-cell lymphoma and Hodgkin lymphoma. Accuracy in a multicenter series of 372 patients. Am J Hematol. 90(8):686-90, 2015
                                            6. Iltis A et al: Decisional early interim (18)F-fluoro-2-deoxy-D-glucose positron emission tomography after two cycles of chemotherapy in de novo Hodgkin lymphoma. Acta Haematol. 133(2):172-8, 2015
                                            7. Rosolen A et al: Revised International Pediatric Non-Hodgkin Lymphoma Staging System. J Clin Oncol. 33(18):2112-8, 2015
                                            8. Cheson BD et al: Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification. J Clin Oncol. 32(27):3059-68, 2014
                                            9. Hutchings M et al: In vivo treatment sensitivity testing with positron emission tomography/computed tomography after one cycle of chemotherapy for Hodgkin lymphoma. J Clin Oncol. 32(25):2705-11, 2014
                                            10. Littooij AS et al: Whole-body MRI for initial staging of paediatric lymphoma: prospective comparison to an FDG-PET/CT-based reference standard. Eur Radiol. 24(5):1153-65, 2014
                                            11. Platzek I et al: FDG PET/MR for the assessment of lymph node involvement in lymphoma: initial results and role of diffusion-weighted MR. Acad Radiol. 21(10):1314-9, 2014
                                            12. Weiler-Sagie M et al: Characterizing bone marrow involvement in Hodgkin's lymphoma by FDG-PET/CT. Eur J Nucl Med Mol Imaging. 41(6):1133-40, 2014
                                            13. Qiu L et al: The role of 18F-FDG PET and 18F-FDG PET/CT in the evaluation of pediatric Hodgkin's lymphoma and non-Hodgkin's lymphoma. Hell J Nucl Med. 16(3):230-6, 2013
                                            14. Biko DM et al: Childhood Burkitt lymphoma: abdominal and pelvic imaging findings. AJR Am J Roentgenol. 192(5):1304-15, 2009
                                            15. Toma P et al: Multimodality imaging of Hodgkin disease and non-Hodgkin lymphomas in children. Radiographics. 27(5):1335-54, 2007
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Pathology

                                                  • Clinical Issues

                                                    • Diagnostic Checklist

                                                      TERMINOLOGY

                                                      • Definitions

                                                        • Malignancy derived from cells of immune system

                                                      IMAGING

                                                      • F-18 FDG PET and PET/CT Findings

                                                        • PET/MR Findings

                                                          • General Features

                                                            • CT Findings

                                                              • MR Findings

                                                                • Imaging Recommendations

                                                                  DIFFERENTIAL DIAGNOSIS

                                                                    PATHOLOGY

                                                                    • General Features

                                                                      • Staging, Grading, & Classification

                                                                        • Gross Pathologic & Surgical Features

                                                                          CLINICAL ISSUES

                                                                          • Presentation

                                                                            • Demographics

                                                                              • Natural History & Prognosis

                                                                                • Treatment

                                                                                  DIAGNOSTIC CHECKLIST

                                                                                  • Image Interpretation Pearls

                                                                                    • Reporting Tips

                                                                                      Selected References

                                                                                      1. Albano D et al: Comparison between whole-body MRI with diffusion-weighted imaging and PET/CT in staging newly diagnosed FDG-avid lymphomas. Eur J Radiol. 85(2):313-8, 2016
                                                                                      2. Kluge R et al: Inter-Reader Reliability of Early FDG-PET/CT Response Assessment Using the Deauville Scale after 2 Cycles of Intensive Chemotherapy (OEPA) in Hodgkin's Lymphoma. PLoS One. 11(3):e0149072, 2016
                                                                                      3. Sher AC et al: Assessment of Sequential PET/MRI in Comparison With PET/CT of Pediatric Lymphoma: A Prospective Study. AJR Am J Roentgenol. 206(3):623-31, 2016
                                                                                      4. Bhojwani D et al: The role of FDG-PET/CT in the evaluation of residual disease in paediatric non-Hodgkin lymphoma. Br J Haematol. 168(6):845-53, 2015
                                                                                      5. Chen-Liang TH et al: The role of bone marrow biopsy and FDG-PET/CT in identifying bone marrow infiltration in the initial diagnosis of high grade non-Hodgkin B-cell lymphoma and Hodgkin lymphoma. Accuracy in a multicenter series of 372 patients. Am J Hematol. 90(8):686-90, 2015
                                                                                      6. Iltis A et al: Decisional early interim (18)F-fluoro-2-deoxy-D-glucose positron emission tomography after two cycles of chemotherapy in de novo Hodgkin lymphoma. Acta Haematol. 133(2):172-8, 2015
                                                                                      7. Rosolen A et al: Revised International Pediatric Non-Hodgkin Lymphoma Staging System. J Clin Oncol. 33(18):2112-8, 2015
                                                                                      8. Cheson BD et al: Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification. J Clin Oncol. 32(27):3059-68, 2014
                                                                                      9. Hutchings M et al: In vivo treatment sensitivity testing with positron emission tomography/computed tomography after one cycle of chemotherapy for Hodgkin lymphoma. J Clin Oncol. 32(25):2705-11, 2014
                                                                                      10. Littooij AS et al: Whole-body MRI for initial staging of paediatric lymphoma: prospective comparison to an FDG-PET/CT-based reference standard. Eur Radiol. 24(5):1153-65, 2014
                                                                                      11. Platzek I et al: FDG PET/MR for the assessment of lymph node involvement in lymphoma: initial results and role of diffusion-weighted MR. Acad Radiol. 21(10):1314-9, 2014
                                                                                      12. Weiler-Sagie M et al: Characterizing bone marrow involvement in Hodgkin's lymphoma by FDG-PET/CT. Eur J Nucl Med Mol Imaging. 41(6):1133-40, 2014
                                                                                      13. Qiu L et al: The role of 18F-FDG PET and 18F-FDG PET/CT in the evaluation of pediatric Hodgkin's lymphoma and non-Hodgkin's lymphoma. Hell J Nucl Med. 16(3):230-6, 2013
                                                                                      14. Biko DM et al: Childhood Burkitt lymphoma: abdominal and pelvic imaging findings. AJR Am J Roentgenol. 192(5):1304-15, 2009
                                                                                      15. Toma P et al: Multimodality imaging of Hodgkin disease and non-Hodgkin lymphomas in children. Radiographics. 27(5):1335-54, 2007