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Peliosis Hepatis
Atif Zaheer, MD; Michael P. Federle, MD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Peliosis hepatis (PH)
            • Synonyms

              • Hepatic peliosis
            • Definitions

              • Rare, benign disorder characterized by sinusoidal dilation with engorgement of capillary bed and presence of multiple blood-filled lacunar spaces within liver

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Ultrasonographic Findings

                    • Angiographic Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Image Interpretation Pearls

                                            Selected References

                                            1. Demyashkin G et al: Peliosis hepatis complicated by portal hypertension following renal transplantation. World J Gastroenterol. 26(34):5220-2, 2020
                                            2. Yoshida M et al: The imaging findings of peliosis hepatis on gadoxetic acid enhanced MRI. Radiol Case Rep. 15(8):1261-5, 2020
                                            3. Dave YA et al: Liver haematoma as a presentation of peliosis hepatis. BMJ Case Rep. 12(2), 2019
                                            4. Liu ZJ et al: [Magnetic resonance imaging and diffusion weighted imaging features of focal peliosis hepatis.] Zhonghua Yi Xue Za Zhi. 99(7):496-9, 2019
                                            5. Yesmembetov K et al: Liver peliosis: a life-threatening condition with no clear indication for liver transplant. Exp Clin Transplant. 16 Suppl 1(Suppl 1):149-51, 2018
                                            6. Zucchetti BM et al: Peliosis hepatis simulates liver metastases. J Glob Oncol. 4:1-3, 2018
                                            7. Elsayes KM et al: A comprehensive approach to hepatic vascular disease. Radiographics. 37(3):813-36, 2017
                                            8. Iwata T et al: Peliosis hepatis mimicking malignant hypervascular tumors. J Gastrointest Surg. 21(6):1095-8, 2017
                                            9. Slim R et al: Education and imaging. hepatobiliary and pancreatic: peliosis hepatis associated with multiple myeloma. J Gastroenterol Hepatol. 29(1):5, 2014
                                            10. Estrogens and oral contraceptives. In LiverTox: Clinical and research information on drug-induced liver injury [Internet]. National Institute of Diabetes and Digestive and Kidney Diseases, 2012
                                            11. Fowell AJ et al: Education and imaging. Hepatobiliary and pancreatic: peliosis hepatis. J Gastroenterol Hepatol. 26(6):1082, 2011
                                            12. Tallón García M et al: [Peliosis hepatitis secondary to hormone treatment.] An Pediatr (Barc). 75(4):286-8, 2011
                                            13. Battal B et al: Multifocal peliosis hepatis: MR and diffusion-weighted MR-imaging findings of an atypical case. Ups J Med Sci. 115(2):153-6, 2010
                                            14. Wannesson L et al: Peliosis hepatis in cancer patients mimicking infection and metastases. Onkologie. 32(1-2):54-6, 2009
                                            15. Torabi M et al: CT of nonneoplastic hepatic vascular and perfusion disorders. Radiographics. 28(7):1967-82, 2008
                                            16. Kim EA et al: Peliosis hepatis with hemorrhagic necrosis and rupture: a case report with emphasis on the multi-detector CT findings. Korean J Radiol. 8(1):64-9, 2007
                                            17. Kim SH et al: Focal peliosis hepatis as a mimicker of hepatic tumors: radiological-pathological correlation. J Comput Assist Tomogr. 31(1):79-85, 2007
                                            18. Pitassi LH et al: Bartonella henselae infects human erythrocytes. Ultrastruct Pathol. 31(6):369-72, 2007
                                            19. Tsirigotis P et al: Peliosis hepatis following treatment with androgen-steroids in patients with bone marrow failure syndromes. Haematologica. 92(11):e106-10, 2007
                                            20. Berzigotti A et al: Peliosis hepatis as an early histological finding in idiopathic portal hypertension: A case report. World J Gastroenterol. 12(22):3612-5, 2006
                                            21. Iannaccone R et al: Peliosis hepatis: spectrum of imaging findings. AJR Am J Roentgenol. 187(1):W43-52, 2006
                                            22. Sandrasegaran K et al: Hepatic peliosis (bacillary angiomatosis) in AIDS: CT findings. Abdom Imaging. 30(6):738-40, 2005
                                            23. Savastano S et al: Pseudotumoral appearance of peliosis hepatis. AJR Am J Roentgenol. 185(2):558-9, 2005
                                            24. Yekeler E et al: Diagnosing of peliosis hepatis by magnetic resonance imaging. J Hepatol. 41(2):351, 2004
                                            25. Gouya H et al: Peliosis hepatis: triphasic helical CT and dynamic MRI findings. Abdom Imaging. 26(5):507-9, 2001
                                            26. Wang SY et al: Hepatic rupture caused by peliosis hepatis. J Pediatr Surg. 36(9):1456-9, 2001
                                            27. Vignaux O et al: Hemorrhagic necrosis due to peliosis hepatis: imaging findings and pathological correlation. Eur Radiol. 9(3):454-6, 1999
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Pathology

                                                    • Clinical Issues

                                                      TERMINOLOGY

                                                      • Abbreviations

                                                        • Peliosis hepatis (PH)
                                                      • Synonyms

                                                        • Hepatic peliosis
                                                      • Definitions

                                                        • Rare, benign disorder characterized by sinusoidal dilation with engorgement of capillary bed and presence of multiple blood-filled lacunar spaces within liver

                                                      IMAGING

                                                      • General Features

                                                        • CT Findings

                                                          • MR Findings

                                                            • Ultrasonographic Findings

                                                              • Angiographic Findings

                                                                • Imaging Recommendations

                                                                  DIFFERENTIAL DIAGNOSIS

                                                                    PATHOLOGY

                                                                    • General Features

                                                                      • Gross Pathologic & Surgical Features

                                                                        • Microscopic Features

                                                                          CLINICAL ISSUES

                                                                          • Presentation

                                                                            • Demographics

                                                                              • Natural History & Prognosis

                                                                                • Treatment

                                                                                  DIAGNOSTIC CHECKLIST

                                                                                  • Consider

                                                                                    • Image Interpretation Pearls

                                                                                      Selected References

                                                                                      1. Demyashkin G et al: Peliosis hepatis complicated by portal hypertension following renal transplantation. World J Gastroenterol. 26(34):5220-2, 2020
                                                                                      2. Yoshida M et al: The imaging findings of peliosis hepatis on gadoxetic acid enhanced MRI. Radiol Case Rep. 15(8):1261-5, 2020
                                                                                      3. Dave YA et al: Liver haematoma as a presentation of peliosis hepatis. BMJ Case Rep. 12(2), 2019
                                                                                      4. Liu ZJ et al: [Magnetic resonance imaging and diffusion weighted imaging features of focal peliosis hepatis.] Zhonghua Yi Xue Za Zhi. 99(7):496-9, 2019
                                                                                      5. Yesmembetov K et al: Liver peliosis: a life-threatening condition with no clear indication for liver transplant. Exp Clin Transplant. 16 Suppl 1(Suppl 1):149-51, 2018
                                                                                      6. Zucchetti BM et al: Peliosis hepatis simulates liver metastases. J Glob Oncol. 4:1-3, 2018
                                                                                      7. Elsayes KM et al: A comprehensive approach to hepatic vascular disease. Radiographics. 37(3):813-36, 2017
                                                                                      8. Iwata T et al: Peliosis hepatis mimicking malignant hypervascular tumors. J Gastrointest Surg. 21(6):1095-8, 2017
                                                                                      9. Slim R et al: Education and imaging. hepatobiliary and pancreatic: peliosis hepatis associated with multiple myeloma. J Gastroenterol Hepatol. 29(1):5, 2014
                                                                                      10. Estrogens and oral contraceptives. In LiverTox: Clinical and research information on drug-induced liver injury [Internet]. National Institute of Diabetes and Digestive and Kidney Diseases, 2012
                                                                                      11. Fowell AJ et al: Education and imaging. Hepatobiliary and pancreatic: peliosis hepatis. J Gastroenterol Hepatol. 26(6):1082, 2011
                                                                                      12. Tallón García M et al: [Peliosis hepatitis secondary to hormone treatment.] An Pediatr (Barc). 75(4):286-8, 2011
                                                                                      13. Battal B et al: Multifocal peliosis hepatis: MR and diffusion-weighted MR-imaging findings of an atypical case. Ups J Med Sci. 115(2):153-6, 2010
                                                                                      14. Wannesson L et al: Peliosis hepatis in cancer patients mimicking infection and metastases. Onkologie. 32(1-2):54-6, 2009
                                                                                      15. Torabi M et al: CT of nonneoplastic hepatic vascular and perfusion disorders. Radiographics. 28(7):1967-82, 2008
                                                                                      16. Kim EA et al: Peliosis hepatis with hemorrhagic necrosis and rupture: a case report with emphasis on the multi-detector CT findings. Korean J Radiol. 8(1):64-9, 2007
                                                                                      17. Kim SH et al: Focal peliosis hepatis as a mimicker of hepatic tumors: radiological-pathological correlation. J Comput Assist Tomogr. 31(1):79-85, 2007
                                                                                      18. Pitassi LH et al: Bartonella henselae infects human erythrocytes. Ultrastruct Pathol. 31(6):369-72, 2007
                                                                                      19. Tsirigotis P et al: Peliosis hepatis following treatment with androgen-steroids in patients with bone marrow failure syndromes. Haematologica. 92(11):e106-10, 2007
                                                                                      20. Berzigotti A et al: Peliosis hepatis as an early histological finding in idiopathic portal hypertension: A case report. World J Gastroenterol. 12(22):3612-5, 2006
                                                                                      21. Iannaccone R et al: Peliosis hepatis: spectrum of imaging findings. AJR Am J Roentgenol. 187(1):W43-52, 2006
                                                                                      22. Sandrasegaran K et al: Hepatic peliosis (bacillary angiomatosis) in AIDS: CT findings. Abdom Imaging. 30(6):738-40, 2005
                                                                                      23. Savastano S et al: Pseudotumoral appearance of peliosis hepatis. AJR Am J Roentgenol. 185(2):558-9, 2005
                                                                                      24. Yekeler E et al: Diagnosing of peliosis hepatis by magnetic resonance imaging. J Hepatol. 41(2):351, 2004
                                                                                      25. Gouya H et al: Peliosis hepatis: triphasic helical CT and dynamic MRI findings. Abdom Imaging. 26(5):507-9, 2001
                                                                                      26. Wang SY et al: Hepatic rupture caused by peliosis hepatis. J Pediatr Surg. 36(9):1456-9, 2001
                                                                                      27. Vignaux O et al: Hemorrhagic necrosis due to peliosis hepatis: imaging findings and pathological correlation. Eur Radiol. 9(3):454-6, 1999