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Diagnosis
Pulmonary Neoplasms
Evaluation of Treatment Response
PERCIST
PERCIST
Brett W. Carter, MD, CPPS
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KEY FACTS

  • Terminology

    • Imaging Anatomy

      • Clinical Implications

        TERMINOLOGY

        • Abbreviations

          • PET response criteria in solid tumors (PERCIST)

        • Definitions

          • Response criteria based primarily on PET findings
            • Metabolic/functional information
            • Anatomic information may also be considered

        • Rationale and Key Concepts

          • Attempt to measure change in accumulation of radiotracer in neoplastic lesions
          • Standardized uptake value (SUV) is most commonly used metric in clinical practice
            • Lean body mass normalized SUV (SUL) has become preferred metric
              • Less susceptible to variations in body weight than SUV
              • SUV comparison depends on identical patient preparation and technical scan parameters between studies
              • Can be calculated by various software

        IMAGING ANATOMY

        • Baseline Measurement Guidelines

          CLINICAL IMPLICATIONS

          • Reassessment

            • Evaluation of Overall Response

              • Confirmation of Response

                Selected References

                1. Basu S et al: Assessment of treatment response using PET. PET Clin. 10(1):9-26, 2015
                2. Fendler WP et al: PET Response Criteria in Solid Tumors Predicts Progression-Free Survival and Time to Local or Distant Progression After Chemotherapy with Regional Hyperthermia for Soft-Tissue Sarcoma. J Nucl Med. 56(4):530-7, 2015
                3. Ordu C et al: Comparison of metabolic and anatomic response to chemotherapy based on PERCIST and RECIST in patients with advanced stage non-small cell lung cancer. Asian Pac J Cancer Prev. 16(1):321-6, 2015
                4. Ding Q et al: PET/CT evaluation of response to chemotherapy in non-small cell lung cancer: PET response criteria in solid tumors (PERCIST) versus response evaluation criteria in solid tumors (RECIST). J Thorac Dis. 6(6):677-83, 2014
                5. Ziai D et al: Therapy response evaluation with FDG-PET/CT in small cell lung cancer: a prognostic and comparison study of the PERCIST and EORTC criteria. Cancer Imaging. 13:73-80, 2013
                6. Wahl RL et al: From RECIST to PERCIST: Evolving Considerations for PET response criteria in solid tumors. J Nucl Med. 50 Suppl 1:122S-50S, 2009
                Related Anatomy
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                Related Differential Diagnoses
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                References
                Tables

                Tables

                KEY FACTS

                • Terminology

                  • Imaging Anatomy

                    • Clinical Implications

                      TERMINOLOGY

                      • Abbreviations

                        • PET response criteria in solid tumors (PERCIST)

                      • Definitions

                        • Response criteria based primarily on PET findings
                          • Metabolic/functional information
                          • Anatomic information may also be considered

                      • Rationale and Key Concepts

                        • Attempt to measure change in accumulation of radiotracer in neoplastic lesions
                        • Standardized uptake value (SUV) is most commonly used metric in clinical practice
                          • Lean body mass normalized SUV (SUL) has become preferred metric
                            • Less susceptible to variations in body weight than SUV
                            • SUV comparison depends on identical patient preparation and technical scan parameters between studies
                            • Can be calculated by various software

                      IMAGING ANATOMY

                      • Baseline Measurement Guidelines

                        CLINICAL IMPLICATIONS

                        • Reassessment

                          • Evaluation of Overall Response

                            • Confirmation of Response

                              Selected References

                              1. Basu S et al: Assessment of treatment response using PET. PET Clin. 10(1):9-26, 2015
                              2. Fendler WP et al: PET Response Criteria in Solid Tumors Predicts Progression-Free Survival and Time to Local or Distant Progression After Chemotherapy with Regional Hyperthermia for Soft-Tissue Sarcoma. J Nucl Med. 56(4):530-7, 2015
                              3. Ordu C et al: Comparison of metabolic and anatomic response to chemotherapy based on PERCIST and RECIST in patients with advanced stage non-small cell lung cancer. Asian Pac J Cancer Prev. 16(1):321-6, 2015
                              4. Ding Q et al: PET/CT evaluation of response to chemotherapy in non-small cell lung cancer: PET response criteria in solid tumors (PERCIST) versus response evaluation criteria in solid tumors (RECIST). J Thorac Dis. 6(6):677-83, 2014
                              5. Ziai D et al: Therapy response evaluation with FDG-PET/CT in small cell lung cancer: a prognostic and comparison study of the PERCIST and EORTC criteria. Cancer Imaging. 13:73-80, 2013
                              6. Wahl RL et al: From RECIST to PERCIST: Evolving Considerations for PET response criteria in solid tumors. J Nucl Med. 50 Suppl 1:122S-50S, 2009