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Periapical Cyst (Radicular)
Kristine M. Mosier, DMD, PhD; Bernadette L. Koch, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Synonyms

                • Radicular cyst
              • Definitions

                • Focal cyst at apex of nonvital tooth
                  • "Apex" = root of tooth
                • Periapical rarefying osteitis = newer term to include periapical cyst, periapical granuloma, and periapical abscess 

              IMAGING

              • General Features

                • Imaging Recommendations

                  • CT Findings

                    • Radiographic Findings

                      • MR Findings

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Image Interpretation Pearls

                                            • Reporting Tips

                                              Selected References

                                              1. Chapman MN et al: Periapical lucency around the tooth: radiologic evaluation and differential diagnosis. Radiographics. 33(1):E15-32, 2013
                                              2. Curé JK et al: Radiopaque jaw lesions: an approach to the differential diagnosis. Radiographics. 32(7):1909-25, 2012
                                              3. Rosenberg PA et al: Evaluation of pathologists (histopathology) and radiologists (cone beam computed tomography) differentiating radicular cysts from granulomas. J Endod. 36(3):423-8, 2010
                                              4. Avelar RL et al: Odontogenic cysts: a clinicopathological study of 507 cases. J Oral Sci. 51(4):581-6, 2009
                                              5. Slootweg PJ: Lesions of the jaws. Histopathology. 54(4):401-18, 2009
                                              6. Erol B et al: Determinants of MR relaxation rates in jaw cysts: implications for diagnostic values of the relaxation times. Dentomaxillofac Radiol. 33(3):183-7, 2004
                                              7. Scholl RJ et al: Cysts and cystic lesions of the mandible: clinical and radiologic-histopathologic review. Radiographics. 19(5):1107-24, 1999
                                              8. Ramachandran Nair PN et al: Types and incidence of human periapical lesions obtained with extracted teeth. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 81(1):93-102, 1996
                                              Related Anatomy
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                                              Related Differential Diagnoses
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                                              References
                                              Tables

                                              Tables

                                              KEY FACTS

                                              • Terminology

                                                • Imaging

                                                  • Top Differential Diagnoses

                                                    • Pathology

                                                      • Clinical Issues

                                                        • Diagnostic Checklist

                                                          TERMINOLOGY

                                                          • Synonyms

                                                            • Radicular cyst
                                                          • Definitions

                                                            • Focal cyst at apex of nonvital tooth
                                                              • "Apex" = root of tooth
                                                            • Periapical rarefying osteitis = newer term to include periapical cyst, periapical granuloma, and periapical abscess 

                                                          IMAGING

                                                          • General Features

                                                            • Imaging Recommendations

                                                              • CT Findings

                                                                • Radiographic Findings

                                                                  • MR Findings

                                                                    DIFFERENTIAL DIAGNOSIS

                                                                      PATHOLOGY

                                                                      • General Features

                                                                        • Gross Pathologic & Surgical Features

                                                                          • Microscopic Features

                                                                            CLINICAL ISSUES

                                                                            • Presentation

                                                                              • Demographics

                                                                                • Natural History & Prognosis

                                                                                  • Treatment

                                                                                    DIAGNOSTIC CHECKLIST

                                                                                    • Consider

                                                                                      • Image Interpretation Pearls

                                                                                        • Reporting Tips

                                                                                          Selected References

                                                                                          1. Chapman MN et al: Periapical lucency around the tooth: radiologic evaluation and differential diagnosis. Radiographics. 33(1):E15-32, 2013
                                                                                          2. Curé JK et al: Radiopaque jaw lesions: an approach to the differential diagnosis. Radiographics. 32(7):1909-25, 2012
                                                                                          3. Rosenberg PA et al: Evaluation of pathologists (histopathology) and radiologists (cone beam computed tomography) differentiating radicular cysts from granulomas. J Endod. 36(3):423-8, 2010
                                                                                          4. Avelar RL et al: Odontogenic cysts: a clinicopathological study of 507 cases. J Oral Sci. 51(4):581-6, 2009
                                                                                          5. Slootweg PJ: Lesions of the jaws. Histopathology. 54(4):401-18, 2009
                                                                                          6. Erol B et al: Determinants of MR relaxation rates in jaw cysts: implications for diagnostic values of the relaxation times. Dentomaxillofac Radiol. 33(3):183-7, 2004
                                                                                          7. Scholl RJ et al: Cysts and cystic lesions of the mandible: clinical and radiologic-histopathologic review. Radiographics. 19(5):1107-24, 1999
                                                                                          8. Ramachandran Nair PN et al: Types and incidence of human periapical lesions obtained with extracted teeth. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 81(1):93-102, 1996