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Persistent Craniopharyngeal Canal
C. Douglas Phillips, MD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Persistent craniopharyngeal canal (PCPC)
            • Synonyms

              • Transsphenoidal canal, craniopharyngeal duct, hypophyseal canal, basipharyngeal canal, persistent hypophyseal canal
            • Definitions

              • Developmental anomaly with persistent tract from nasopharyngeal roof to pituitary fossa
                • May represent persistent Rathke duct
                  • Alternative hypothesis: Persistent vascular channel unrelated to Rathke duct

            IMAGING

            • General Features

              • Imaging Recommendations

                • CT Findings

                  • MR Findings

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        CLINICAL ISSUES

                        • Presentation

                          • Demographics

                            • Natural History & Prognosis

                              • Treatment

                                DIAGNOSTIC CHECKLIST

                                • Image Interpretation Pearls

                                  Selected References

                                  1. Mohindra S et al: A novel minimally invasive endoscopic repair in a case of spontaneous CSF rhinorrhea with persistent craniopharyngeal canal. Neurol India. 63(3):434-6, 2015
                                  2. Abele TA et al: Craniopharyngeal canal and its spectrum of pathology. AJNR Am J Neuroradiol. 35(4):772-7, 2014
                                  3. Alatzoglou KS et al: SOX3 deletion in mouse and human is associated with persistence of the craniopharyngeal canal. J Clin Endocrinol Metab. 99(12):E2702-8, 2014
                                  4. Ginat DT et al: Multi-detector-row computed tomography imaging of variant skull base foramina. J Comput Assist Tomogr. 37(4):481-5, 2013
                                  5. Kaushik C et al: Ectopic pituitary adenoma in persistent craniopharyngeal canal: case report and literature review. J Comput Assist Tomogr. 34(4):612-4, 2010
                                  6. Pinilla-Arias D et al: Recurrent meningitis and persistence of craniopharyngeal canal: case report. Neurocirugia (Astur). 20(1):50-3, 2009
                                  7. Marsot-Dupuch K et al: A rare expression of neural crest disorders: an intrasphenoidal development of the anterior pituitary gland. AJNR Am J Neuroradiol. 25(2):285-8, 2004
                                  8. Ekinci G et al: Transsphenoidal (large craniopharyngeal) canal associated with a normally functioning pituitary gland and nasopharyngeal extension, hyperprolactinemia, and hypothalamic hamartoma. AJR Am J Roentgenol. 180(1):76-7, 2003
                                  9. Hughes ML et al: Persistent hypophyseal (craniopharyngeal) canal. Br J Radiol. 72(854):204-6, 1999
                                  10. Madeline LA et al: Postnatal development of the central skull base: normal variants. Radiology. 196(3):757-63, 1995
                                  11. Lowman RM et al: The craniopharyngeal canal. Acta Radiol Diagn (Stockh). 5:41-54, 1966
                                  12. Arey LB: The craniopharyngeal canal reviewed and reinterpreted. Anat Rec. 106(1):1-16, 1950
                                  Related Anatomy
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                                  Related Differential Diagnoses
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                                  References
                                  Tables

                                  Tables

                                  KEY FACTS

                                  • Terminology

                                    • Imaging

                                      • Top Differential Diagnoses

                                        • Pathology

                                          • Clinical Issues

                                            TERMINOLOGY

                                            • Abbreviations

                                              • Persistent craniopharyngeal canal (PCPC)
                                            • Synonyms

                                              • Transsphenoidal canal, craniopharyngeal duct, hypophyseal canal, basipharyngeal canal, persistent hypophyseal canal
                                            • Definitions

                                              • Developmental anomaly with persistent tract from nasopharyngeal roof to pituitary fossa
                                                • May represent persistent Rathke duct
                                                  • Alternative hypothesis: Persistent vascular channel unrelated to Rathke duct

                                            IMAGING

                                            • General Features

                                              • Imaging Recommendations

                                                • CT Findings

                                                  • MR Findings

                                                    DIFFERENTIAL DIAGNOSIS

                                                      PATHOLOGY

                                                      • General Features

                                                        CLINICAL ISSUES

                                                        • Presentation

                                                          • Demographics

                                                            • Natural History & Prognosis

                                                              • Treatment

                                                                DIAGNOSTIC CHECKLIST

                                                                • Image Interpretation Pearls

                                                                  Selected References

                                                                  1. Mohindra S et al: A novel minimally invasive endoscopic repair in a case of spontaneous CSF rhinorrhea with persistent craniopharyngeal canal. Neurol India. 63(3):434-6, 2015
                                                                  2. Abele TA et al: Craniopharyngeal canal and its spectrum of pathology. AJNR Am J Neuroradiol. 35(4):772-7, 2014
                                                                  3. Alatzoglou KS et al: SOX3 deletion in mouse and human is associated with persistence of the craniopharyngeal canal. J Clin Endocrinol Metab. 99(12):E2702-8, 2014
                                                                  4. Ginat DT et al: Multi-detector-row computed tomography imaging of variant skull base foramina. J Comput Assist Tomogr. 37(4):481-5, 2013
                                                                  5. Kaushik C et al: Ectopic pituitary adenoma in persistent craniopharyngeal canal: case report and literature review. J Comput Assist Tomogr. 34(4):612-4, 2010
                                                                  6. Pinilla-Arias D et al: Recurrent meningitis and persistence of craniopharyngeal canal: case report. Neurocirugia (Astur). 20(1):50-3, 2009
                                                                  7. Marsot-Dupuch K et al: A rare expression of neural crest disorders: an intrasphenoidal development of the anterior pituitary gland. AJNR Am J Neuroradiol. 25(2):285-8, 2004
                                                                  8. Ekinci G et al: Transsphenoidal (large craniopharyngeal) canal associated with a normally functioning pituitary gland and nasopharyngeal extension, hyperprolactinemia, and hypothalamic hamartoma. AJR Am J Roentgenol. 180(1):76-7, 2003
                                                                  9. Hughes ML et al: Persistent hypophyseal (craniopharyngeal) canal. Br J Radiol. 72(854):204-6, 1999
                                                                  10. Madeline LA et al: Postnatal development of the central skull base: normal variants. Radiology. 196(3):757-63, 1995
                                                                  11. Lowman RM et al: The craniopharyngeal canal. Acta Radiol Diagn (Stockh). 5:41-54, 1966
                                                                  12. Arey LB: The craniopharyngeal canal reviewed and reinterpreted. Anat Rec. 106(1):1-16, 1950