Persistent fetal vasculature = new term in recent literature
Congenital lesion due to incomplete regression of embryonic ocular blood supply
Failure of hyaloid vasculature to regress
IMAGING
General Features
CT Findings
MR Findings
Ultrasonographic Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Chiaroni PM et al: Diagnostic accuracy of quantitative colour doppler flow imaging in distinguishing persistent fetal vasculature from retinal detachment. Acta Ophthalmol. ePub, 2021
Prakhunhungsit S et al: Diagnostic and management strategies in patients with persistent fetal vasculature: current insights. Clin Ophthalmol. 14:4325-35, 2020
Wang J et al: Atypical anterior persistent hyperplastic primary vitreous: report of a rare case. BMC Ophthalmol. 20(1):290, 2020
Burns NS et al: Diagnostic imaging of fetal and pediatric orbital abnormalities. AJR Am J Roentgenol. 201(6):W797-808, 2013
Rizvi SW et al: Bilateral persistent hyperplastic primary vitreous: a close mimic of retinoblastoma. Semin Ophthalmol. 28(1):25-7, 2013
Brennan RC et al: US and MRI of pediatric ocular masses with histopathological correlation. Pediatr Radiol. 42(6):738-49, 2012
Khokhar S et al: Approach to cataract with persistent hyperplastic primary vitreous. J Cataract Refract Surg. 37(8):1382-5, 2011
Cerón O et al: The vitreo-retinal manifestations of persistent hyperplasic primary vitreous (PHPV) and their management. Int Ophthalmol Clin. 48(2):53-62, 2008
Katorza E et al: Prenatal ultrasonographic diagnosis of persistent hyperplastic primary vitreous. Ultrasound Obstet Gynecol. 32(2):226-8, 2008
Robinson AJ et al: MRI of the fetal eyes: morphologic and biometric assessment for abnormal development with ultrasonographic and clinicopathologic correlation. Pediatr Radiol. 38(9):971-81, 2008
Balmer A et al: Differential diagnosis of leukocoria and strabismus, first presenting signs of retinoblastoma. Clin Ophthalmol. 1(4):431-9, 2007
Schulz E et al: Long-term visual function and relative amblyopia in posterior persistent hyperplastic primary vitreous (PHPV). Strabismus. 14(2):121-5, 2006
Mackeen LD et al: High-frequency ultrasonography findings in persistent hyperplastic primary vitreous. J AAPOS. 4(4):217-24, 2000
Dass AB et al: Surgical results of persistent hyperplastic primary vitreous. Ophthalmology. 106(2):280-4, 1999
Castillo M et al: Persistent hyperplastic primary vitreous involving the anterior eye. AJNR Am J Neuroradiol. 18(8):1526-8, 1997
Pollard ZF: Persistent hyperplastic primary vitreous: diagnosis, treatment and results. Trans Am Ophthalmol Soc. 95(1):487-549, 1997
Kaste SC et al: Persistent hyperplastic primary vitreous of the eye: imaging findings with pathologic correlation. AJR Am J Roentgenol. 162(2):437-40, 1994
Mafee MF et al: Persistent hyperplastic primary vitreous (PHPV): role of computed tomography and magnetic resonance. Radiol Clin North Am. 25(4):683-92, 1987
Related Anatomy
Loading...
Related Differential Diagnoses
Loading...
References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
Persistent hyperplastic primary vitreous (PHPV)
Definitions
Persistent fetal vasculature = new term in recent literature
Congenital lesion due to incomplete regression of embryonic ocular blood supply
Failure of hyaloid vasculature to regress
IMAGING
General Features
CT Findings
MR Findings
Ultrasonographic Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Chiaroni PM et al: Diagnostic accuracy of quantitative colour doppler flow imaging in distinguishing persistent fetal vasculature from retinal detachment. Acta Ophthalmol. ePub, 2021
Prakhunhungsit S et al: Diagnostic and management strategies in patients with persistent fetal vasculature: current insights. Clin Ophthalmol. 14:4325-35, 2020
Wang J et al: Atypical anterior persistent hyperplastic primary vitreous: report of a rare case. BMC Ophthalmol. 20(1):290, 2020
Burns NS et al: Diagnostic imaging of fetal and pediatric orbital abnormalities. AJR Am J Roentgenol. 201(6):W797-808, 2013
Rizvi SW et al: Bilateral persistent hyperplastic primary vitreous: a close mimic of retinoblastoma. Semin Ophthalmol. 28(1):25-7, 2013
Brennan RC et al: US and MRI of pediatric ocular masses with histopathological correlation. Pediatr Radiol. 42(6):738-49, 2012
Khokhar S et al: Approach to cataract with persistent hyperplastic primary vitreous. J Cataract Refract Surg. 37(8):1382-5, 2011
Cerón O et al: The vitreo-retinal manifestations of persistent hyperplasic primary vitreous (PHPV) and their management. Int Ophthalmol Clin. 48(2):53-62, 2008
Katorza E et al: Prenatal ultrasonographic diagnosis of persistent hyperplastic primary vitreous. Ultrasound Obstet Gynecol. 32(2):226-8, 2008
Robinson AJ et al: MRI of the fetal eyes: morphologic and biometric assessment for abnormal development with ultrasonographic and clinicopathologic correlation. Pediatr Radiol. 38(9):971-81, 2008
Balmer A et al: Differential diagnosis of leukocoria and strabismus, first presenting signs of retinoblastoma. Clin Ophthalmol. 1(4):431-9, 2007
Schulz E et al: Long-term visual function and relative amblyopia in posterior persistent hyperplastic primary vitreous (PHPV). Strabismus. 14(2):121-5, 2006
Mackeen LD et al: High-frequency ultrasonography findings in persistent hyperplastic primary vitreous. J AAPOS. 4(4):217-24, 2000
Dass AB et al: Surgical results of persistent hyperplastic primary vitreous. Ophthalmology. 106(2):280-4, 1999
Castillo M et al: Persistent hyperplastic primary vitreous involving the anterior eye. AJNR Am J Neuroradiol. 18(8):1526-8, 1997
Pollard ZF: Persistent hyperplastic primary vitreous: diagnosis, treatment and results. Trans Am Ophthalmol Soc. 95(1):487-549, 1997
Kaste SC et al: Persistent hyperplastic primary vitreous of the eye: imaging findings with pathologic correlation. AJR Am J Roentgenol. 162(2):437-40, 1994
Mafee MF et al: Persistent hyperplastic primary vitreous (PHPV): role of computed tomography and magnetic resonance. Radiol Clin North Am. 25(4):683-92, 1987
STATdx includes over 200,000 searchable images, including x-ray, CT, MR, and ultrasound images. To access all images, please log in or subscribe.