Tumor with monomorphic piloid cells dispersed in mucopolysaccharide-rich matrix
More aggressive tumor than PA with high risk of local recurrence, dissemination
IMAGING
General Features
CT Findings
MR Findings
Other Modality Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
He J et al: Posterior fossa pilomyxoid astrocytoma with spontaneous hemorrhage in pediatric patients. Childs Nerv Syst. 34(1):149-53, 2018
Louis DN et al: The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol. 131(6):803-20, 2016
Wang Z et al: Spontaneous intratumoural and intraventricular haemorrhage associated with a pilomyxoid astrocytoma in the hypothalamic/chiasmatic region. J Clin Neurosci. 33:217-20, 2016
Alkonyi B et al: Differential imaging characteristics and dissemination potential of pilomyxoid astrocytomas versus pilocytic astrocytomas. Neuroradiology. 57(6):625-38, 2015
Amarasinghe SG et al: A rare case of multicystic disseminated astrocytoma with pilomyxoid characteristics in a 4-year-old child. Childs Nerv Syst. 31(4):625-9, 2015
Nabavizadeh SA et al: High accuracy of arterial spin labeling perfusion imaging in differentiation of pilomyxoid from pilocytic astrocytoma. Neuroradiology. 57(5):527-33, 2015
El Beltagy MA et al: Surgical and clinical aspects of cerebellar pilomyxoid-spectrum astrocytomas in children. Childs Nerv Syst. 30(6):1045-53, 2014
Kleinschmidt-DeMasters BK et al: Pilomyxoid astrocytoma (PMA) shows significant differences in gene expression vs. pilocytic astrocytoma (PA) and variable tendency toward maturation to PA. Brain Pathol. 25(4):429-40, 2015
Amirjamshidi A et al: Pilomyxoid astrocytoma. J Neurosurg Pediatr. 11(5):613, 2013
Bhargava D et al: Occurrence and distribution of pilomyxoid astrocytoma. Br J Neurosurg. 27(4):413-8, 2013
Lee IH et al: Imaging characteristics of pilomyxoid astrocytomas in comparison with pilocytic astrocytomas. Eur J Radiol. 79(2):311-6, 2011
Johnson MW et al: Spectrum of pilomyxoid astrocytomas: intermediate pilomyxoid tumors. Am J Surg Pathol. 34(12):1783-91, 2010
Amatya VJ et al: Clinicopathological and immunohistochemical features of three pilomyxoid astrocytomas: comparative study with 11 pilocytic astrocytomas. Pathol Int. 59(2):80-5, 2009
Buccoliero AM et al: Occipital pilomyxoid astrocytoma in a 14-year-old girl--case report. Clin Neuropathol. 27(6):373-7, 2008
Komotar RJ et al: Magnetic resonance imaging characteristics of pilomyxoid astrocytoma. Neurol Res. 30(9):945-51, 2008
Linscott LL et al: Pilomyxoid astrocytoma: expanding the imaging spectrum. AJNR Am J Neuroradiol. 29(10):1861-6, 2008
Brat DJ et al: Newly codified glial neoplasms of the 2007 WHO Classification of Tumours of the Central Nervous System: angiocentric glioma, pilomyxoid astrocytoma and pituicytoma. Brain Pathol. 17(3):319-24, 2007
Ceppa EP et al: The pilomyxoid astrocytoma and its relationship to pilocytic astrocytoma: report of a case and a critical review of the entity. J Neurooncol. 81(2):191-6, 2007
Morales H et al: Magnetic resonance imaging and spectroscopy of pilomyxoid astrocytomas: case reports and comparison with pilocytic astrocytomas. J Comput Assist Tomogr. 31(5):682-7, 2007
Komotar RJ et al: Astrocytoma with pilomyxoid features presenting in an adult. Neuropathology. 26(1):89-93, 2006
Melendez B et al: BCR gene disruption in a pilomyxoid astrocytoma. Neuropathology. 26(5):442-6, 2006
Cirak B et al: Proton magnetic resonance spectroscopic imaging in pediatric pilomyxoid astrocytoma. Childs Nerv Syst. 21(5):404-9, 2005
Komotar RJ et al: Pilomyxoid astrocytoma of the spinal cord: report of three cases. Neurosurgery. 56(1):191, 2005
Chikai K et al: Clinico-pathological features of pilomyxoid astrocytoma of the optic pathway. Acta Neuropathol (Berl). 108(2):109-14, 2004
Darwish B et al: Juvenile pilocytic astrocytoma 'pilomyxoid variant' with spinal metastases. J Clin Neurosci. 11(6):640-2, 2004
Komotar RJ et al: Pilomyxoid astrocytoma: a review. MedGenMed. 6(4):42, 2004
Arslanoglu A et al: MR imaging characteristics of pilomyxoid astrocytomas. AJNR Am J Neuroradiol. 24(9):1906-8, 2003
Burger PC et al: Pathology of diencephalic astrocytomas. Pediatr Neurosurg. 32(4):214-9, 2000
Tihan T et al: Pediatric astrocytomas with monomorphous pilomyxoid features and a less favorable outcome. J Neuropathol Exp Neurol. 58(10):1061-8, 1999
Related Anatomy
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
Pilomyxoid astrocytoma (PMA)
Myxoid variant of pilocytic astrocytoma (PA)
Definitions
Tumor with monomorphic piloid cells dispersed in mucopolysaccharide-rich matrix
More aggressive tumor than PA with high risk of local recurrence, dissemination
IMAGING
General Features
CT Findings
MR Findings
Other Modality Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
He J et al: Posterior fossa pilomyxoid astrocytoma with spontaneous hemorrhage in pediatric patients. Childs Nerv Syst. 34(1):149-53, 2018
Louis DN et al: The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol. 131(6):803-20, 2016
Wang Z et al: Spontaneous intratumoural and intraventricular haemorrhage associated with a pilomyxoid astrocytoma in the hypothalamic/chiasmatic region. J Clin Neurosci. 33:217-20, 2016
Alkonyi B et al: Differential imaging characteristics and dissemination potential of pilomyxoid astrocytomas versus pilocytic astrocytomas. Neuroradiology. 57(6):625-38, 2015
Amarasinghe SG et al: A rare case of multicystic disseminated astrocytoma with pilomyxoid characteristics in a 4-year-old child. Childs Nerv Syst. 31(4):625-9, 2015
Nabavizadeh SA et al: High accuracy of arterial spin labeling perfusion imaging in differentiation of pilomyxoid from pilocytic astrocytoma. Neuroradiology. 57(5):527-33, 2015
El Beltagy MA et al: Surgical and clinical aspects of cerebellar pilomyxoid-spectrum astrocytomas in children. Childs Nerv Syst. 30(6):1045-53, 2014
Kleinschmidt-DeMasters BK et al: Pilomyxoid astrocytoma (PMA) shows significant differences in gene expression vs. pilocytic astrocytoma (PA) and variable tendency toward maturation to PA. Brain Pathol. 25(4):429-40, 2015
Amirjamshidi A et al: Pilomyxoid astrocytoma. J Neurosurg Pediatr. 11(5):613, 2013
Bhargava D et al: Occurrence and distribution of pilomyxoid astrocytoma. Br J Neurosurg. 27(4):413-8, 2013
Lee IH et al: Imaging characteristics of pilomyxoid astrocytomas in comparison with pilocytic astrocytomas. Eur J Radiol. 79(2):311-6, 2011
Johnson MW et al: Spectrum of pilomyxoid astrocytomas: intermediate pilomyxoid tumors. Am J Surg Pathol. 34(12):1783-91, 2010
Amatya VJ et al: Clinicopathological and immunohistochemical features of three pilomyxoid astrocytomas: comparative study with 11 pilocytic astrocytomas. Pathol Int. 59(2):80-5, 2009
Buccoliero AM et al: Occipital pilomyxoid astrocytoma in a 14-year-old girl--case report. Clin Neuropathol. 27(6):373-7, 2008
Komotar RJ et al: Magnetic resonance imaging characteristics of pilomyxoid astrocytoma. Neurol Res. 30(9):945-51, 2008
Linscott LL et al: Pilomyxoid astrocytoma: expanding the imaging spectrum. AJNR Am J Neuroradiol. 29(10):1861-6, 2008
Brat DJ et al: Newly codified glial neoplasms of the 2007 WHO Classification of Tumours of the Central Nervous System: angiocentric glioma, pilomyxoid astrocytoma and pituicytoma. Brain Pathol. 17(3):319-24, 2007
Ceppa EP et al: The pilomyxoid astrocytoma and its relationship to pilocytic astrocytoma: report of a case and a critical review of the entity. J Neurooncol. 81(2):191-6, 2007
Morales H et al: Magnetic resonance imaging and spectroscopy of pilomyxoid astrocytomas: case reports and comparison with pilocytic astrocytomas. J Comput Assist Tomogr. 31(5):682-7, 2007
Komotar RJ et al: Astrocytoma with pilomyxoid features presenting in an adult. Neuropathology. 26(1):89-93, 2006
Melendez B et al: BCR gene disruption in a pilomyxoid astrocytoma. Neuropathology. 26(5):442-6, 2006
Cirak B et al: Proton magnetic resonance spectroscopic imaging in pediatric pilomyxoid astrocytoma. Childs Nerv Syst. 21(5):404-9, 2005
Komotar RJ et al: Pilomyxoid astrocytoma of the spinal cord: report of three cases. Neurosurgery. 56(1):191, 2005
Chikai K et al: Clinico-pathological features of pilomyxoid astrocytoma of the optic pathway. Acta Neuropathol (Berl). 108(2):109-14, 2004
Darwish B et al: Juvenile pilocytic astrocytoma 'pilomyxoid variant' with spinal metastases. J Clin Neurosci. 11(6):640-2, 2004
Komotar RJ et al: Pilomyxoid astrocytoma: a review. MedGenMed. 6(4):42, 2004
Arslanoglu A et al: MR imaging characteristics of pilomyxoid astrocytomas. AJNR Am J Neuroradiol. 24(9):1906-8, 2003
Burger PC et al: Pathology of diencephalic astrocytomas. Pediatr Neurosurg. 32(4):214-9, 2000
Tihan T et al: Pediatric astrocytomas with monomorphous pilomyxoid features and a less favorable outcome. J Neuropathol Exp Neurol. 58(10):1061-8, 1999
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