Occurs primarily (but not exclusively) in children
Poorly differentiated
Aggressive behavior
Poor prognosis
IMAGING
General Features
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Reporting Tips
Selected References
Li BK et al: Pineoblastoma segregates into molecular sub-groups with distinct clinico-pathologic features: a Rare Brain Tumor Consortium registry study. Acta Neuropathol. 139(2):223-41, 2020
Choque-Velasquez J et al: Pineal parenchymal tumors of intermediate differentiation: a long-term follow-up study in Helsinki neurosurgery. World Neurosurg. 122:e729-39, 2019
Corrigenda. Neuro Oncol. 19(12):1702, 2017
Tamrazi B et al: Pineal region masses in pediatric patients. Neuroimaging Clin N Am. 27(1):85-97, 2017
Jouvet A. et al: Pineal parenchymal tumour of intermediate differentiation. In DN Louis et al: WHO Classification of Tumours of the Central Nervous System. IARC Press. 173-75, 2016
Yu T et al: Twenty-seven cases of pineal parenchymal tumours of intermediate differentiation: mitotic count, Ki-67 labelling index and extent of resection predict prognosis. J Neurol Neurosurg Psychiatry. ePub, 2015
Ito T et al: Clinicopathologic study of pineal parenchymal tumors of intermediate differentiation. World Neurosurg. 81(5-6):783-9, 2014
Kakigi T et al: Quantitative imaging values of CT, MR, and FDG-PET to differentiate pineal parenchymal tumors and germinomas: are they useful? Neuroradiology. 56(4):297-303, 2014
Watanabe T et al: Pineal parenchymal tumor of intermediate differentiation: Treatment outcomes of five cases. Mol Clin Oncol. 2(2):197-202, 2014
Fukuoka K et al: Pineal parenchymal tumor of intermediate differentiation with marked elevation of MIB-1 labeling index. Brain Tumor Pathol. Epub ahead of print, 2012
Han SJ et al: Pathology of pineal parenchymal tumors. Neurosurg Clin N Am. 22(3):335-40, 2011
Komakula S et al: Pineal parenchymal tumor of intermediate differentiation: imaging spectrum of an unusual tumor in 11 cases. Neuroradiology. 53(8):577-84, 2011
Kim BS et al: Pineal parenchymal tumor of intermediate differentiation showing malignant progression at relapse. Neuropathology. 29(5):602-8, 2009
Sato K et al: Pathology of pineal parenchymal tumors. Prog Neurol Surg. 23:12-25, 2009
Fèvre-Montange M et al: Pineocytoma and pineal parenchymal tumors of intermediate differentiation presenting cytologic pleomorphism: a multicenter study. Brain Pathol. 18(3):354-9, 2008
Rousseau A et al: The 2007 WHO classification of tumors of the central nervous system - what has changed? Curr Opin Neurol. 21(6):720-7, 2008
Senft C et al: Pineal parenchymal tumor of intermediate differentiation: diagnostic pitfalls and discussion of treatment options of a rare tumor entity. Neurosurg Rev. 31(2):231-6, 2008
Nakazato Y et al: Pineal parenchymal tumour of intermediate differentiation. In DN Louis et al: WHO Classification of Tumours of the Central Nervous System. IARC Press. 124-5, 2007
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
Pineal parenchymal tumor of intermediate differentiation (PPTID)
Synonyms
Atypical pineocytoma (outdated term)
Definitions
Primary parenchymal neoplasm of pineal gland
Intermediate in malignancy between pineocytoma and pineoblastoma
Pineocytoma (WHO grade 1): Slow-growing neoplasm with small mature cells that resemble pineocytes
Adults predominate
Well-differentiated histology with large "pineocytomatous rosettes"
Indolent course (imaging may remain stable for years)
Occurs primarily (but not exclusively) in children
Poorly differentiated
Aggressive behavior
Poor prognosis
IMAGING
General Features
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Reporting Tips
Selected References
Li BK et al: Pineoblastoma segregates into molecular sub-groups with distinct clinico-pathologic features: a Rare Brain Tumor Consortium registry study. Acta Neuropathol. 139(2):223-41, 2020
Choque-Velasquez J et al: Pineal parenchymal tumors of intermediate differentiation: a long-term follow-up study in Helsinki neurosurgery. World Neurosurg. 122:e729-39, 2019
Corrigenda. Neuro Oncol. 19(12):1702, 2017
Tamrazi B et al: Pineal region masses in pediatric patients. Neuroimaging Clin N Am. 27(1):85-97, 2017
Jouvet A. et al: Pineal parenchymal tumour of intermediate differentiation. In DN Louis et al: WHO Classification of Tumours of the Central Nervous System. IARC Press. 173-75, 2016
Yu T et al: Twenty-seven cases of pineal parenchymal tumours of intermediate differentiation: mitotic count, Ki-67 labelling index and extent of resection predict prognosis. J Neurol Neurosurg Psychiatry. ePub, 2015
Ito T et al: Clinicopathologic study of pineal parenchymal tumors of intermediate differentiation. World Neurosurg. 81(5-6):783-9, 2014
Kakigi T et al: Quantitative imaging values of CT, MR, and FDG-PET to differentiate pineal parenchymal tumors and germinomas: are they useful? Neuroradiology. 56(4):297-303, 2014
Watanabe T et al: Pineal parenchymal tumor of intermediate differentiation: Treatment outcomes of five cases. Mol Clin Oncol. 2(2):197-202, 2014
Fukuoka K et al: Pineal parenchymal tumor of intermediate differentiation with marked elevation of MIB-1 labeling index. Brain Tumor Pathol. Epub ahead of print, 2012
Han SJ et al: Pathology of pineal parenchymal tumors. Neurosurg Clin N Am. 22(3):335-40, 2011
Komakula S et al: Pineal parenchymal tumor of intermediate differentiation: imaging spectrum of an unusual tumor in 11 cases. Neuroradiology. 53(8):577-84, 2011
Kim BS et al: Pineal parenchymal tumor of intermediate differentiation showing malignant progression at relapse. Neuropathology. 29(5):602-8, 2009
Sato K et al: Pathology of pineal parenchymal tumors. Prog Neurol Surg. 23:12-25, 2009
Fèvre-Montange M et al: Pineocytoma and pineal parenchymal tumors of intermediate differentiation presenting cytologic pleomorphism: a multicenter study. Brain Pathol. 18(3):354-9, 2008
Rousseau A et al: The 2007 WHO classification of tumors of the central nervous system - what has changed? Curr Opin Neurol. 21(6):720-7, 2008
Senft C et al: Pineal parenchymal tumor of intermediate differentiation: diagnostic pitfalls and discussion of treatment options of a rare tumor entity. Neurosurg Rev. 31(2):231-6, 2008
Nakazato Y et al: Pineal parenchymal tumour of intermediate differentiation. In DN Louis et al: WHO Classification of Tumours of the Central Nervous System. IARC Press. 124-5, 2007
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