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Pineoblastoma
Anne G. Osborn, MD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Pineoblastoma (PB)
              • Definitions

                • Highly cellular, poorly differentiated malignant embryonal tumor of pineal gland

              IMAGING

              • General Features

                • CT Findings

                  • MR Findings

                    • Angiographic Findings

                      • Nuclear Medicine Findings

                        • Other Modality Findings

                          • Imaging Recommendations

                            DIFFERENTIAL DIAGNOSIS

                              PATHOLOGY

                              • General Features

                                • Staging, Grading, & Classification

                                  • Gross Pathologic & Surgical Features

                                    • Microscopic Features

                                      CLINICAL ISSUES

                                      • Presentation

                                        • Demographics

                                          • Natural History & Prognosis

                                            • Treatment

                                              DIAGNOSTIC CHECKLIST

                                              • Consider

                                                • Image Interpretation Pearls

                                                  • Clinical Pearl

                                                    Selected References

                                                    1. Abdelbaki MS et al: Pineoblastoma in children less than six years of age: the Head Start I, II, and III experience. Pediatr Blood Cancer. e28252, 2020
                                                    2. Jin MC et al: Patterns of care and age-specific impact of extent of resection and adjuvant radiotherapy in pediatric pineoblastoma. Neurosurgery. 86(5):E426-35, 2020
                                                    3. Li BK et al: Pediatric embryonal brain tumors in the molecular era. Expert Rev Mol Diagn. 20(3):293-303, 2020
                                                    4. Li BK et al: Pineoblastoma segregates into molecular sub-groups with distinct clinico-pathologic features: a Rare Brain Tumor Consortium registry study. Acta Neuropathol. 139(2):223-41, 2020
                                                    5. Liu APY et al: Risk-adapted therapy and biological heterogeneity in pineoblastoma: integrated clinico-pathological analysis from the prospective, multi-center SJMB03 and SJYC07 trials. Acta Neuropathol. 139(2):259-71, 2020
                                                    6. Pfaff E et al: Molecular subgrouping of primary pineal parenchymal tumors reveals distinct subtypes correlated with clinical parameters and genetic alterations. Acta Neuropathol. 139(2):243-57, 2020
                                                    7. de Kock L et al: An update on the central nervous system manifestations of DICER1 syndrome. Acta Neuropathol. 139(4):689-701, 2019
                                                    8. Gaito S et al: Pineoblastoma in adults: a rare case successfully treated with multimodal approach including craniospinal irradiation using helical tomotherapy. Cureus. 11(10):e5852, 2019
                                                    9. Parikh KA et al: Pineoblastoma-the experience at St. Jude Children's Research Hospital. Neurosurgery. 81(1):120-8, 2017
                                                    10. Tamrazi B et al: Pineal region masses in pediatric patients. Neuroimaging Clin N Am. 27(1):85-97, 2017
                                                    11. Alkhotani A et al: A 49 year-old woman with a pineal mass. Brain Pathol. 24(2):191-2, 2014
                                                    Related Anatomy
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                                                    Related Differential Diagnoses
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                                                    References
                                                    Tables

                                                    Tables

                                                    KEY FACTS

                                                    • Terminology

                                                      • Imaging

                                                        • Top Differential Diagnoses

                                                          • Pathology

                                                            • Clinical Issues

                                                              • Diagnostic Checklist

                                                                TERMINOLOGY

                                                                • Abbreviations

                                                                  • Pineoblastoma (PB)
                                                                • Definitions

                                                                  • Highly cellular, poorly differentiated malignant embryonal tumor of pineal gland

                                                                IMAGING

                                                                • General Features

                                                                  • CT Findings

                                                                    • MR Findings

                                                                      • Angiographic Findings

                                                                        • Nuclear Medicine Findings

                                                                          • Other Modality Findings

                                                                            • Imaging Recommendations

                                                                              DIFFERENTIAL DIAGNOSIS

                                                                                PATHOLOGY

                                                                                • General Features

                                                                                  • Staging, Grading, & Classification

                                                                                    • Gross Pathologic & Surgical Features

                                                                                      • Microscopic Features

                                                                                        CLINICAL ISSUES

                                                                                        • Presentation

                                                                                          • Demographics

                                                                                            • Natural History & Prognosis

                                                                                              • Treatment

                                                                                                DIAGNOSTIC CHECKLIST

                                                                                                • Consider

                                                                                                  • Image Interpretation Pearls

                                                                                                    • Clinical Pearl

                                                                                                      Selected References

                                                                                                      1. Abdelbaki MS et al: Pineoblastoma in children less than six years of age: the Head Start I, II, and III experience. Pediatr Blood Cancer. e28252, 2020
                                                                                                      2. Jin MC et al: Patterns of care and age-specific impact of extent of resection and adjuvant radiotherapy in pediatric pineoblastoma. Neurosurgery. 86(5):E426-35, 2020
                                                                                                      3. Li BK et al: Pediatric embryonal brain tumors in the molecular era. Expert Rev Mol Diagn. 20(3):293-303, 2020
                                                                                                      4. Li BK et al: Pineoblastoma segregates into molecular sub-groups with distinct clinico-pathologic features: a Rare Brain Tumor Consortium registry study. Acta Neuropathol. 139(2):223-41, 2020
                                                                                                      5. Liu APY et al: Risk-adapted therapy and biological heterogeneity in pineoblastoma: integrated clinico-pathological analysis from the prospective, multi-center SJMB03 and SJYC07 trials. Acta Neuropathol. 139(2):259-71, 2020
                                                                                                      6. Pfaff E et al: Molecular subgrouping of primary pineal parenchymal tumors reveals distinct subtypes correlated with clinical parameters and genetic alterations. Acta Neuropathol. 139(2):243-57, 2020
                                                                                                      7. de Kock L et al: An update on the central nervous system manifestations of DICER1 syndrome. Acta Neuropathol. 139(4):689-701, 2019
                                                                                                      8. Gaito S et al: Pineoblastoma in adults: a rare case successfully treated with multimodal approach including craniospinal irradiation using helical tomotherapy. Cureus. 11(10):e5852, 2019
                                                                                                      9. Parikh KA et al: Pineoblastoma-the experience at St. Jude Children's Research Hospital. Neurosurgery. 81(1):120-8, 2017
                                                                                                      10. Tamrazi B et al: Pineal region masses in pediatric patients. Neuroimaging Clin N Am. 27(1):85-97, 2017
                                                                                                      11. Alkhotani A et al: A 49 year-old woman with a pineal mass. Brain Pathol. 24(2):191-2, 2014