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Pineoblastoma
Luke L. Linscott, MD; Anne G. Osborn, MD, FACR; Laurie A. Loevner, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Pineoblastoma (PB)
              • Synonyms

                • Primitive neuroectodermal tumor (PNET) of pineal gland
              • Definitions

                • Highly malignant embryonal tumor of pineal gland
                • Pineal parenchymal tumor (not germ cell tumor)

              IMAGING

              • General Features

                • CT Findings

                  • MR Findings

                    • Angiographic Findings

                      • Nuclear Medicine Findings

                        • Other Modality Findings

                          • Imaging Recommendations

                            DIFFERENTIAL DIAGNOSIS

                              PATHOLOGY

                              • General Features

                                • Staging, Grading, & Classification

                                  • Gross Pathologic & Surgical Features

                                    • Microscopic Features

                                      CLINICAL ISSUES

                                      • Presentation

                                        • Demographics

                                          • Natural History & Prognosis

                                            • Treatment

                                              DIAGNOSTIC CHECKLIST

                                              • Consider

                                                • Image Interpretation Pearls

                                                  • Clinical Pearl

                                                    Selected References

                                                    1. Deng X et al: Prognosis of pediatric patients with pineoblastoma: a SEER analysis 1990-2013. World Neurosurg. 118:e871-9, 2018
                                                    2. Galluzzi P et al: MRI-based assessment of the pineal gland in a large population of children aged 0-5 years and comparison with pineoblastoma: part I, the solid gland. Neuroradiology. 58(7):705-12, 2016
                                                    3. Sirin S et al: MRI-based assessment of the pineal gland in a large population of children aged 0-5 years and comparison with pineoblastoma: part II, the cystic gland. Neuroradiology. 58(7):713-21, 2016
                                                    4. Sturm D et al: New brain tumor entities emerge from molecular classification of CNS-PNETs. Cell. 164(5):1060-72, 2016
                                                    5. Choudhri AF et al: Diffusion characteristics of pediatric pineal tumors. Neuroradiol J. 28(2):209-16, 2015
                                                    6. Awa R et al: Neuroimaging diagnosis of pineal region tumors-quest for pathognomonic finding of germinoma. Neuroradiology. 56(7):525-34, 2014
                                                    7. de Kock L et al: Germ-line and somatic DICER1 mutations in pineoblastoma. Acta Neuropathol. 128(4):583-95, 2014
                                                    8. Farnia B et al: Clinical outcomes and patterns of failure in pineoblastoma: a 30-year, single-institution retrospective review. World Neurosurg. 82(6):1232-1241, 2014
                                                    9. Jouvet A et al: Pineal parenchymal tumours and pineal cysts. Neurochirurgie. ePub, 2014
                                                    10. Kakigi T et al: Quantitative imaging values of CT, MR, and FDG-PET to differentiate pineal parenchymal tumors and germinomas: are they useful? Neuroradiology. 56(4):297-303, 2014
                                                    11. Ramasubramanian A et al: Incidence of pineal gland cyst and pineoblastoma in children with retinoblastoma during the chemoreduction era. Am J Ophthalmol. 156(4):825-9, 2013
                                                    12. Dumrongpisutikul N et al: Distinguishing between germinomas and pineal cell tumors on MR imaging. AJNR Am J Neuroradiol. 33(3):550-5, 2012
                                                    13. Amemiya S et al: Recently established entities of central nervous system tumors: review of radiological findings. J Comput Assist Tomogr. 32(2):279-85, 2008
                                                    14. Gasparetto EL et al: Diffusion-weighted MR images and pineoblastoma: diagnosis and follow-up. Arq Neuropsiquiatr. 66(1):64-8, 2008
                                                    15. Senft C et al: Pineal parenchymal tumor of intermediate differentiation: diagnostic pitfalls and discussion of treatment options of a rare tumor entity. Neurosurg Rev. 31(2):231-6, 2008
                                                    16. Cuccia V et al: Pinealoblastomas in children. Childs Nerv Syst. 22(6):577-85, 2006
                                                    17. Reis F et al: Neuroimaging in pineal tumors. J Neuroimaging. 16(1):52-8, 2006
                                                    18. Roberts CC et al: Imaging of the pineal region and spine: self-assessment module. AJR Am J Roentgenol. 186(3 Suppl):S224-6, 2006
                                                    19. Kondziolka D et al: The role of radiosurgery for the treatment of pineal parenchymal tumors. Neurosurgery. 51(4): 880-9, 2002
                                                    20. Lutterbach J et al: Malignant pineal parenchymal tumors in adult patients: patterns of care and prognostic factors. Neurosurgery. 51(1): 44-55; discussion 55-6, 2002
                                                    21. Hirato J et al: Pathology of pineal region tumors. J Neurooncol. 54(3): 239-49, 2001
                                                    22. Korogi Y et al: MRI of pineal region tumors. J Neurooncol. 54(3): 251-61, 2001
                                                    23. Jouvet A et al: Pineal parenchymal tumors: a correlation of histological features with prognosis in 66 cases. Brain Pathol. 10(1):49-60, 2000
                                                    24. Nakamura M et al: Neuroradiological characteristics of pineocytoma and pineoblastoma. Neuroradiology. 42(7):509-14, 2000
                                                    Related Anatomy
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                                                    Related Differential Diagnoses
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                                                    References
                                                    Tables

                                                    Tables

                                                    KEY FACTS

                                                    • Terminology

                                                      • Imaging

                                                        • Top Differential Diagnoses

                                                          • Pathology

                                                            • Clinical Issues

                                                              • Diagnostic Checklist

                                                                TERMINOLOGY

                                                                • Abbreviations

                                                                  • Pineoblastoma (PB)
                                                                • Synonyms

                                                                  • Primitive neuroectodermal tumor (PNET) of pineal gland
                                                                • Definitions

                                                                  • Highly malignant embryonal tumor of pineal gland
                                                                  • Pineal parenchymal tumor (not germ cell tumor)

                                                                IMAGING

                                                                • General Features

                                                                  • CT Findings

                                                                    • MR Findings

                                                                      • Angiographic Findings

                                                                        • Nuclear Medicine Findings

                                                                          • Other Modality Findings

                                                                            • Imaging Recommendations

                                                                              DIFFERENTIAL DIAGNOSIS

                                                                                PATHOLOGY

                                                                                • General Features

                                                                                  • Staging, Grading, & Classification

                                                                                    • Gross Pathologic & Surgical Features

                                                                                      • Microscopic Features

                                                                                        CLINICAL ISSUES

                                                                                        • Presentation

                                                                                          • Demographics

                                                                                            • Natural History & Prognosis

                                                                                              • Treatment

                                                                                                DIAGNOSTIC CHECKLIST

                                                                                                • Consider

                                                                                                  • Image Interpretation Pearls

                                                                                                    • Clinical Pearl

                                                                                                      Selected References

                                                                                                      1. Deng X et al: Prognosis of pediatric patients with pineoblastoma: a SEER analysis 1990-2013. World Neurosurg. 118:e871-9, 2018
                                                                                                      2. Galluzzi P et al: MRI-based assessment of the pineal gland in a large population of children aged 0-5 years and comparison with pineoblastoma: part I, the solid gland. Neuroradiology. 58(7):705-12, 2016
                                                                                                      3. Sirin S et al: MRI-based assessment of the pineal gland in a large population of children aged 0-5 years and comparison with pineoblastoma: part II, the cystic gland. Neuroradiology. 58(7):713-21, 2016
                                                                                                      4. Sturm D et al: New brain tumor entities emerge from molecular classification of CNS-PNETs. Cell. 164(5):1060-72, 2016
                                                                                                      5. Choudhri AF et al: Diffusion characteristics of pediatric pineal tumors. Neuroradiol J. 28(2):209-16, 2015
                                                                                                      6. Awa R et al: Neuroimaging diagnosis of pineal region tumors-quest for pathognomonic finding of germinoma. Neuroradiology. 56(7):525-34, 2014
                                                                                                      7. de Kock L et al: Germ-line and somatic DICER1 mutations in pineoblastoma. Acta Neuropathol. 128(4):583-95, 2014
                                                                                                      8. Farnia B et al: Clinical outcomes and patterns of failure in pineoblastoma: a 30-year, single-institution retrospective review. World Neurosurg. 82(6):1232-1241, 2014
                                                                                                      9. Jouvet A et al: Pineal parenchymal tumours and pineal cysts. Neurochirurgie. ePub, 2014
                                                                                                      10. Kakigi T et al: Quantitative imaging values of CT, MR, and FDG-PET to differentiate pineal parenchymal tumors and germinomas: are they useful? Neuroradiology. 56(4):297-303, 2014
                                                                                                      11. Ramasubramanian A et al: Incidence of pineal gland cyst and pineoblastoma in children with retinoblastoma during the chemoreduction era. Am J Ophthalmol. 156(4):825-9, 2013
                                                                                                      12. Dumrongpisutikul N et al: Distinguishing between germinomas and pineal cell tumors on MR imaging. AJNR Am J Neuroradiol. 33(3):550-5, 2012
                                                                                                      13. Amemiya S et al: Recently established entities of central nervous system tumors: review of radiological findings. J Comput Assist Tomogr. 32(2):279-85, 2008
                                                                                                      14. Gasparetto EL et al: Diffusion-weighted MR images and pineoblastoma: diagnosis and follow-up. Arq Neuropsiquiatr. 66(1):64-8, 2008
                                                                                                      15. Senft C et al: Pineal parenchymal tumor of intermediate differentiation: diagnostic pitfalls and discussion of treatment options of a rare tumor entity. Neurosurg Rev. 31(2):231-6, 2008
                                                                                                      16. Cuccia V et al: Pinealoblastomas in children. Childs Nerv Syst. 22(6):577-85, 2006
                                                                                                      17. Reis F et al: Neuroimaging in pineal tumors. J Neuroimaging. 16(1):52-8, 2006
                                                                                                      18. Roberts CC et al: Imaging of the pineal region and spine: self-assessment module. AJR Am J Roentgenol. 186(3 Suppl):S224-6, 2006
                                                                                                      19. Kondziolka D et al: The role of radiosurgery for the treatment of pineal parenchymal tumors. Neurosurgery. 51(4): 880-9, 2002
                                                                                                      20. Lutterbach J et al: Malignant pineal parenchymal tumors in adult patients: patterns of care and prognostic factors. Neurosurgery. 51(1): 44-55; discussion 55-6, 2002
                                                                                                      21. Hirato J et al: Pathology of pineal region tumors. J Neurooncol. 54(3): 239-49, 2001
                                                                                                      22. Korogi Y et al: MRI of pineal region tumors. J Neurooncol. 54(3): 251-61, 2001
                                                                                                      23. Jouvet A et al: Pineal parenchymal tumors: a correlation of histological features with prognosis in 66 cases. Brain Pathol. 10(1):49-60, 2000
                                                                                                      24. Nakamura M et al: Neuroradiological characteristics of pineocytoma and pineoblastoma. Neuroradiology. 42(7):509-14, 2000