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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Pineoblastoma (PB)
Synonyms
- Primitive neuroectodermal tumor (PNET) of pineal gland
Definitions
- Highly malignant embryonal tumor of pineal gland
- Pineal parenchymal tumor (not germ cell tumor)
IMAGING
General Features
CT Findings
MR Findings
Angiographic Findings
Nuclear Medicine Findings
Other Modality Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Clinical Pearl
Selected References
- Deng X et al: Prognosis of pediatric patients with pineoblastoma: a SEER analysis 1990-2013. World Neurosurg. 118:e871-9, 2018
- Galluzzi P et al: MRI-based assessment of the pineal gland in a large population of children aged 0-5 years and comparison with pineoblastoma: part I, the solid gland. Neuroradiology. 58(7):705-12, 2016
- Sirin S et al: MRI-based assessment of the pineal gland in a large population of children aged 0-5 years and comparison with pineoblastoma: part II, the cystic gland. Neuroradiology. 58(7):713-21, 2016
- Sturm D et al: New brain tumor entities emerge from molecular classification of CNS-PNETs. Cell. 164(5):1060-72, 2016
- Choudhri AF et al: Diffusion characteristics of pediatric pineal tumors. Neuroradiol J. 28(2):209-16, 2015
- Awa R et al: Neuroimaging diagnosis of pineal region tumors-quest for pathognomonic finding of germinoma. Neuroradiology. 56(7):525-34, 2014
- de Kock L et al: Germ-line and somatic DICER1 mutations in pineoblastoma. Acta Neuropathol. 128(4):583-95, 2014
- Farnia B et al: Clinical outcomes and patterns of failure in pineoblastoma: a 30-year, single-institution retrospective review. World Neurosurg. 82(6):1232-1241, 2014
- Jouvet A et al: Pineal parenchymal tumours and pineal cysts. Neurochirurgie. ePub, 2014
- Kakigi T et al: Quantitative imaging values of CT, MR, and FDG-PET to differentiate pineal parenchymal tumors and germinomas: are they useful? Neuroradiology. 56(4):297-303, 2014
- Ramasubramanian A et al: Incidence of pineal gland cyst and pineoblastoma in children with retinoblastoma during the chemoreduction era. Am J Ophthalmol. 156(4):825-9, 2013
- Dumrongpisutikul N et al: Distinguishing between germinomas and pineal cell tumors on MR imaging. AJNR Am J Neuroradiol. 33(3):550-5, 2012
- Amemiya S et al: Recently established entities of central nervous system tumors: review of radiological findings. J Comput Assist Tomogr. 32(2):279-85, 2008
- Gasparetto EL et al: Diffusion-weighted MR images and pineoblastoma: diagnosis and follow-up. Arq Neuropsiquiatr. 66(1):64-8, 2008
- Senft C et al: Pineal parenchymal tumor of intermediate differentiation: diagnostic pitfalls and discussion of treatment options of a rare tumor entity. Neurosurg Rev. 31(2):231-6, 2008
- Cuccia V et al: Pinealoblastomas in children. Childs Nerv Syst. 22(6):577-85, 2006
- Reis F et al: Neuroimaging in pineal tumors. J Neuroimaging. 16(1):52-8, 2006
- Roberts CC et al: Imaging of the pineal region and spine: self-assessment module. AJR Am J Roentgenol. 186(3 Suppl):S224-6, 2006
- Kondziolka D et al: The role of radiosurgery for the treatment of pineal parenchymal tumors. Neurosurgery. 51(4): 880-9, 2002
- Lutterbach J et al: Malignant pineal parenchymal tumors in adult patients: patterns of care and prognostic factors. Neurosurgery. 51(1): 44-55; discussion 55-6, 2002
- Hirato J et al: Pathology of pineal region tumors. J Neurooncol. 54(3): 239-49, 2001
- Korogi Y et al: MRI of pineal region tumors. J Neurooncol. 54(3): 251-61, 2001
- Jouvet A et al: Pineal parenchymal tumors: a correlation of histological features with prognosis in 66 cases. Brain Pathol. 10(1):49-60, 2000
- Nakamura M et al: Neuroradiological characteristics of pineocytoma and pineoblastoma. Neuroradiology. 42(7):509-14, 2000
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Pineoblastoma (PB)
Synonyms
- Primitive neuroectodermal tumor (PNET) of pineal gland
Definitions
- Highly malignant embryonal tumor of pineal gland
- Pineal parenchymal tumor (not germ cell tumor)
IMAGING
General Features
CT Findings
MR Findings
Angiographic Findings
Nuclear Medicine Findings
Other Modality Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Clinical Pearl
Selected References
- Deng X et al: Prognosis of pediatric patients with pineoblastoma: a SEER analysis 1990-2013. World Neurosurg. 118:e871-9, 2018
- Galluzzi P et al: MRI-based assessment of the pineal gland in a large population of children aged 0-5 years and comparison with pineoblastoma: part I, the solid gland. Neuroradiology. 58(7):705-12, 2016
- Sirin S et al: MRI-based assessment of the pineal gland in a large population of children aged 0-5 years and comparison with pineoblastoma: part II, the cystic gland. Neuroradiology. 58(7):713-21, 2016
- Sturm D et al: New brain tumor entities emerge from molecular classification of CNS-PNETs. Cell. 164(5):1060-72, 2016
- Choudhri AF et al: Diffusion characteristics of pediatric pineal tumors. Neuroradiol J. 28(2):209-16, 2015
- Awa R et al: Neuroimaging diagnosis of pineal region tumors-quest for pathognomonic finding of germinoma. Neuroradiology. 56(7):525-34, 2014
- de Kock L et al: Germ-line and somatic DICER1 mutations in pineoblastoma. Acta Neuropathol. 128(4):583-95, 2014
- Farnia B et al: Clinical outcomes and patterns of failure in pineoblastoma: a 30-year, single-institution retrospective review. World Neurosurg. 82(6):1232-1241, 2014
- Jouvet A et al: Pineal parenchymal tumours and pineal cysts. Neurochirurgie. ePub, 2014
- Kakigi T et al: Quantitative imaging values of CT, MR, and FDG-PET to differentiate pineal parenchymal tumors and germinomas: are they useful? Neuroradiology. 56(4):297-303, 2014
- Ramasubramanian A et al: Incidence of pineal gland cyst and pineoblastoma in children with retinoblastoma during the chemoreduction era. Am J Ophthalmol. 156(4):825-9, 2013
- Dumrongpisutikul N et al: Distinguishing between germinomas and pineal cell tumors on MR imaging. AJNR Am J Neuroradiol. 33(3):550-5, 2012
- Amemiya S et al: Recently established entities of central nervous system tumors: review of radiological findings. J Comput Assist Tomogr. 32(2):279-85, 2008
- Gasparetto EL et al: Diffusion-weighted MR images and pineoblastoma: diagnosis and follow-up. Arq Neuropsiquiatr. 66(1):64-8, 2008
- Senft C et al: Pineal parenchymal tumor of intermediate differentiation: diagnostic pitfalls and discussion of treatment options of a rare tumor entity. Neurosurg Rev. 31(2):231-6, 2008
- Cuccia V et al: Pinealoblastomas in children. Childs Nerv Syst. 22(6):577-85, 2006
- Reis F et al: Neuroimaging in pineal tumors. J Neuroimaging. 16(1):52-8, 2006
- Roberts CC et al: Imaging of the pineal region and spine: self-assessment module. AJR Am J Roentgenol. 186(3 Suppl):S224-6, 2006
- Kondziolka D et al: The role of radiosurgery for the treatment of pineal parenchymal tumors. Neurosurgery. 51(4): 880-9, 2002
- Lutterbach J et al: Malignant pineal parenchymal tumors in adult patients: patterns of care and prognostic factors. Neurosurgery. 51(1): 44-55; discussion 55-6, 2002
- Hirato J et al: Pathology of pineal region tumors. J Neurooncol. 54(3): 239-49, 2001
- Korogi Y et al: MRI of pineal region tumors. J Neurooncol. 54(3): 251-61, 2001
- Jouvet A et al: Pineal parenchymal tumors: a correlation of histological features with prognosis in 66 cases. Brain Pathol. 10(1):49-60, 2000
- Nakamura M et al: Neuroradiological characteristics of pineocytoma and pineoblastoma. Neuroradiology. 42(7):509-14, 2000
