Primitive neuroectodermal tumor (PNET) of pineal gland
Definitions
Highly malignant embryonal tumor of pineal gland
Pineal parenchymal tumor (not germ cell tumor)
IMAGING
General Features
CT Findings
MR Findings
Angiographic Findings
Nuclear Medicine Findings
Other Modality Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Clinical Pearl
Selected References
Deng X et al: Prognosis of pediatric patients with pineoblastoma: a SEER analysis 1990-2013. World Neurosurg. 118:e871-9, 2018
Galluzzi P et al: MRI-based assessment of the pineal gland in a large population of children aged 0-5 years and comparison with pineoblastoma: part I, the solid gland. Neuroradiology. 58(7):705-12, 2016
Sirin S et al: MRI-based assessment of the pineal gland in a large population of children aged 0-5 years and comparison with pineoblastoma: part II, the cystic gland. Neuroradiology. 58(7):713-21, 2016
Sturm D et al: New brain tumor entities emerge from molecular classification of CNS-PNETs. Cell. 164(5):1060-72, 2016
Choudhri AF et al: Diffusion characteristics of pediatric pineal tumors. Neuroradiol J. 28(2):209-16, 2015
Awa R et al: Neuroimaging diagnosis of pineal region tumors-quest for pathognomonic finding of germinoma. Neuroradiology. 56(7):525-34, 2014
de Kock L et al: Germ-line and somatic DICER1 mutations in pineoblastoma. Acta Neuropathol. 128(4):583-95, 2014
Farnia B et al: Clinical outcomes and patterns of failure in pineoblastoma: a 30-year, single-institution retrospective review. World Neurosurg. 82(6):1232-1241, 2014
Jouvet A et al: Pineal parenchymal tumours and pineal cysts. Neurochirurgie. ePub, 2014
Kakigi T et al: Quantitative imaging values of CT, MR, and FDG-PET to differentiate pineal parenchymal tumors and germinomas: are they useful? Neuroradiology. 56(4):297-303, 2014
Ramasubramanian A et al: Incidence of pineal gland cyst and pineoblastoma in children with retinoblastoma during the chemoreduction era. Am J Ophthalmol. 156(4):825-9, 2013
Dumrongpisutikul N et al: Distinguishing between germinomas and pineal cell tumors on MR imaging. AJNR Am J Neuroradiol. 33(3):550-5, 2012
Amemiya S et al: Recently established entities of central nervous system tumors: review of radiological findings. J Comput Assist Tomogr. 32(2):279-85, 2008
Gasparetto EL et al: Diffusion-weighted MR images and pineoblastoma: diagnosis and follow-up. Arq Neuropsiquiatr. 66(1):64-8, 2008
Senft C et al: Pineal parenchymal tumor of intermediate differentiation: diagnostic pitfalls and discussion of treatment options of a rare tumor entity. Neurosurg Rev. 31(2):231-6, 2008
Cuccia V et al: Pinealoblastomas in children. Childs Nerv Syst. 22(6):577-85, 2006
Reis F et al: Neuroimaging in pineal tumors. J Neuroimaging. 16(1):52-8, 2006
Roberts CC et al: Imaging of the pineal region and spine: self-assessment module. AJR Am J Roentgenol. 186(3 Suppl):S224-6, 2006
Kondziolka D et al: The role of radiosurgery for the treatment of pineal parenchymal tumors. Neurosurgery. 51(4): 880-9, 2002
Lutterbach J et al: Malignant pineal parenchymal tumors in adult patients: patterns of care and prognostic factors. Neurosurgery. 51(1): 44-55; discussion 55-6, 2002
Hirato J et al: Pathology of pineal region tumors. J Neurooncol. 54(3): 239-49, 2001
Korogi Y et al: MRI of pineal region tumors. J Neurooncol. 54(3): 251-61, 2001
Jouvet A et al: Pineal parenchymal tumors: a correlation of histological features with prognosis in 66 cases. Brain Pathol. 10(1):49-60, 2000
Nakamura M et al: Neuroradiological characteristics of pineocytoma and pineoblastoma. Neuroradiology. 42(7):509-14, 2000
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References
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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
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Diagnostic Checklist
TERMINOLOGY
Abbreviations
Pineoblastoma (PB)
Synonyms
Primitive neuroectodermal tumor (PNET) of pineal gland
Definitions
Highly malignant embryonal tumor of pineal gland
Pineal parenchymal tumor (not germ cell tumor)
IMAGING
General Features
CT Findings
MR Findings
Angiographic Findings
Nuclear Medicine Findings
Other Modality Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Clinical Pearl
Selected References
Deng X et al: Prognosis of pediatric patients with pineoblastoma: a SEER analysis 1990-2013. World Neurosurg. 118:e871-9, 2018
Galluzzi P et al: MRI-based assessment of the pineal gland in a large population of children aged 0-5 years and comparison with pineoblastoma: part I, the solid gland. Neuroradiology. 58(7):705-12, 2016
Sirin S et al: MRI-based assessment of the pineal gland in a large population of children aged 0-5 years and comparison with pineoblastoma: part II, the cystic gland. Neuroradiology. 58(7):713-21, 2016
Sturm D et al: New brain tumor entities emerge from molecular classification of CNS-PNETs. Cell. 164(5):1060-72, 2016
Choudhri AF et al: Diffusion characteristics of pediatric pineal tumors. Neuroradiol J. 28(2):209-16, 2015
Awa R et al: Neuroimaging diagnosis of pineal region tumors-quest for pathognomonic finding of germinoma. Neuroradiology. 56(7):525-34, 2014
de Kock L et al: Germ-line and somatic DICER1 mutations in pineoblastoma. Acta Neuropathol. 128(4):583-95, 2014
Farnia B et al: Clinical outcomes and patterns of failure in pineoblastoma: a 30-year, single-institution retrospective review. World Neurosurg. 82(6):1232-1241, 2014
Jouvet A et al: Pineal parenchymal tumours and pineal cysts. Neurochirurgie. ePub, 2014
Kakigi T et al: Quantitative imaging values of CT, MR, and FDG-PET to differentiate pineal parenchymal tumors and germinomas: are they useful? Neuroradiology. 56(4):297-303, 2014
Ramasubramanian A et al: Incidence of pineal gland cyst and pineoblastoma in children with retinoblastoma during the chemoreduction era. Am J Ophthalmol. 156(4):825-9, 2013
Dumrongpisutikul N et al: Distinguishing between germinomas and pineal cell tumors on MR imaging. AJNR Am J Neuroradiol. 33(3):550-5, 2012
Amemiya S et al: Recently established entities of central nervous system tumors: review of radiological findings. J Comput Assist Tomogr. 32(2):279-85, 2008
Gasparetto EL et al: Diffusion-weighted MR images and pineoblastoma: diagnosis and follow-up. Arq Neuropsiquiatr. 66(1):64-8, 2008
Senft C et al: Pineal parenchymal tumor of intermediate differentiation: diagnostic pitfalls and discussion of treatment options of a rare tumor entity. Neurosurg Rev. 31(2):231-6, 2008
Cuccia V et al: Pinealoblastomas in children. Childs Nerv Syst. 22(6):577-85, 2006
Reis F et al: Neuroimaging in pineal tumors. J Neuroimaging. 16(1):52-8, 2006
Roberts CC et al: Imaging of the pineal region and spine: self-assessment module. AJR Am J Roentgenol. 186(3 Suppl):S224-6, 2006
Kondziolka D et al: The role of radiosurgery for the treatment of pineal parenchymal tumors. Neurosurgery. 51(4): 880-9, 2002
Lutterbach J et al: Malignant pineal parenchymal tumors in adult patients: patterns of care and prognostic factors. Neurosurgery. 51(1): 44-55; discussion 55-6, 2002
Hirato J et al: Pathology of pineal region tumors. J Neurooncol. 54(3): 239-49, 2001
Korogi Y et al: MRI of pineal region tumors. J Neurooncol. 54(3): 251-61, 2001
Jouvet A et al: Pineal parenchymal tumors: a correlation of histological features with prognosis in 66 cases. Brain Pathol. 10(1):49-60, 2000
Nakamura M et al: Neuroradiological characteristics of pineocytoma and pineoblastoma. Neuroradiology. 42(7):509-14, 2000
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