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Pineoblastoma
Laurie A. Loevner, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Pathology

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Pinealoblastoma (PB)
            • Pineal parenchymal tumor (PPT)
          • Synonyms

            • Primitive neuroectodermal tumor (PNET) of pineal gland
          • Definitions

            • Highly malignant primitive embryonal tumor of pineal gland

          IMAGING

          • General Features

            • CT Findings

              • MR Findings

                • Angiographic Findings

                  • Nuclear Medicine Findings

                    • Other Modality Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Staging, Grading, & Classification

                              • Gross Pathologic & Surgical Features

                                • Microscopic Features

                                  CLINICAL ISSUES

                                  • Presentation

                                    • Demographics

                                      • Natural History & Prognosis

                                        • Treatment

                                          DIAGNOSTIC CHECKLIST

                                          • Consider

                                            • Image Interpretation Pearls

                                              • Clinical Pearl

                                                Selected References

                                                1. Kakigi T et al: Quantitative imaging values of CT, MR, and FDG-PET to differentiate pineal parenchymal tumors and germinomas: are they useful? Neuroradiology. 56(4):297-303, 2014
                                                2. Ramasubramanian A et al: Incidence of pineal gland cyst and pineoblastoma in children with retinoblastoma during the chemoreduction era. Am J Ophthalmol. 156(4):825-9, 2013
                                                3. Dumrongpisutikul N et al: Distinguishing between germinomas and pineal cell tumors on MR imaging. AJNR Am J Neuroradiol. 33(3):550-5, 2012
                                                4. VillĂ  S et al: Primary pineal tumors: outcome and prognostic factors--a study from the Rare Cancer Network (RCN). Clin Transl Oncol. 14(11):827-34, 2012
                                                5. Papaioannou G et al: Imaging of the unusual pediatric 'blastomas'. Cancer Imaging. 9:1-11, 2009
                                                6. Amemiya S et al: Recently established entities of central nervous system tumors: review of radiological findings. J Comput Assist Tomogr. 32(2):279-85, 2008
                                                7. Gasparetto EL et al: Diffusion-weighted MR images and pineoblastoma: diagnosis and follow-up. Arq Neuropsiquiatr. 66(1):64-8, 2008
                                                8. Senft C et al: Pineal parenchymal tumor of intermediate differentiation: diagnostic pitfalls and discussion of treatment options of a rare tumor entity. Neurosurg Rev. 31(2):231-6, 2008
                                                9. Cuccia V et al: Pinealoblastomas in children. Childs Nerv Syst. 22(6):577-85, 2006
                                                10. Reis F et al: Neuroimaging in pineal tumors. J Neuroimaging. 16(1):52-8, 2006
                                                11. Roberts CC et al: Imaging of the pineal region and spine: self-assessment module. AJR Am J Roentgenol. 186(3 Suppl):S224-6, 2006
                                                12. Konovalov AN et al: Principles of treatment of the pineal region tumors. Surg Neurol. 59(4): 250-68, 2003
                                                13. Kondziolka D et al: The role of radiosurgery for the treatment of pineal parenchymal tumors. Neurosurgery. 51(4): 880-9, 2002
                                                14. Lutterbach J et al: Malignant pineal parenchymal tumors in adult patients: patterns of care and prognostic factors. Neurosurgery. 51(1): 44-55; discussion 55-6, 2002
                                                15. Hirato J et al: Pathology of pineal region tumors. J Neurooncol. 54(3): 239-49, 2001
                                                16. Korogi Y et al: MRI of pineal region tumors. J Neurooncol. 54(3): 251-61, 2001
                                                17. Jouvet A et al: Pineal parenchymal tumors: a correlation of histological features with prognosis in 66 cases. Brain Pathol. 10(1):49-60, 2000
                                                18. Nakamura M et al: Neuroradiological characteristics of pineocytoma and pineoblastoma. Neuroradiology. 42(7):509-14, 2000
                                                Related Anatomy
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                                                Related Differential Diagnoses
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                                                References
                                                Tables

                                                Tables

                                                KEY FACTS

                                                • Terminology

                                                  • Imaging

                                                    • Pathology

                                                      • Clinical Issues

                                                        TERMINOLOGY

                                                        • Abbreviations

                                                          • Pinealoblastoma (PB)
                                                          • Pineal parenchymal tumor (PPT)
                                                        • Synonyms

                                                          • Primitive neuroectodermal tumor (PNET) of pineal gland
                                                        • Definitions

                                                          • Highly malignant primitive embryonal tumor of pineal gland

                                                        IMAGING

                                                        • General Features

                                                          • CT Findings

                                                            • MR Findings

                                                              • Angiographic Findings

                                                                • Nuclear Medicine Findings

                                                                  • Other Modality Findings

                                                                    • Imaging Recommendations

                                                                      DIFFERENTIAL DIAGNOSIS

                                                                        PATHOLOGY

                                                                        • General Features

                                                                          • Staging, Grading, & Classification

                                                                            • Gross Pathologic & Surgical Features

                                                                              • Microscopic Features

                                                                                CLINICAL ISSUES

                                                                                • Presentation

                                                                                  • Demographics

                                                                                    • Natural History & Prognosis

                                                                                      • Treatment

                                                                                        DIAGNOSTIC CHECKLIST

                                                                                        • Consider

                                                                                          • Image Interpretation Pearls

                                                                                            • Clinical Pearl

                                                                                              Selected References

                                                                                              1. Kakigi T et al: Quantitative imaging values of CT, MR, and FDG-PET to differentiate pineal parenchymal tumors and germinomas: are they useful? Neuroradiology. 56(4):297-303, 2014
                                                                                              2. Ramasubramanian A et al: Incidence of pineal gland cyst and pineoblastoma in children with retinoblastoma during the chemoreduction era. Am J Ophthalmol. 156(4):825-9, 2013
                                                                                              3. Dumrongpisutikul N et al: Distinguishing between germinomas and pineal cell tumors on MR imaging. AJNR Am J Neuroradiol. 33(3):550-5, 2012
                                                                                              4. VillĂ  S et al: Primary pineal tumors: outcome and prognostic factors--a study from the Rare Cancer Network (RCN). Clin Transl Oncol. 14(11):827-34, 2012
                                                                                              5. Papaioannou G et al: Imaging of the unusual pediatric 'blastomas'. Cancer Imaging. 9:1-11, 2009
                                                                                              6. Amemiya S et al: Recently established entities of central nervous system tumors: review of radiological findings. J Comput Assist Tomogr. 32(2):279-85, 2008
                                                                                              7. Gasparetto EL et al: Diffusion-weighted MR images and pineoblastoma: diagnosis and follow-up. Arq Neuropsiquiatr. 66(1):64-8, 2008
                                                                                              8. Senft C et al: Pineal parenchymal tumor of intermediate differentiation: diagnostic pitfalls and discussion of treatment options of a rare tumor entity. Neurosurg Rev. 31(2):231-6, 2008
                                                                                              9. Cuccia V et al: Pinealoblastomas in children. Childs Nerv Syst. 22(6):577-85, 2006
                                                                                              10. Reis F et al: Neuroimaging in pineal tumors. J Neuroimaging. 16(1):52-8, 2006
                                                                                              11. Roberts CC et al: Imaging of the pineal region and spine: self-assessment module. AJR Am J Roentgenol. 186(3 Suppl):S224-6, 2006
                                                                                              12. Konovalov AN et al: Principles of treatment of the pineal region tumors. Surg Neurol. 59(4): 250-68, 2003
                                                                                              13. Kondziolka D et al: The role of radiosurgery for the treatment of pineal parenchymal tumors. Neurosurgery. 51(4): 880-9, 2002
                                                                                              14. Lutterbach J et al: Malignant pineal parenchymal tumors in adult patients: patterns of care and prognostic factors. Neurosurgery. 51(1): 44-55; discussion 55-6, 2002
                                                                                              15. Hirato J et al: Pathology of pineal region tumors. J Neurooncol. 54(3): 239-49, 2001
                                                                                              16. Korogi Y et al: MRI of pineal region tumors. J Neurooncol. 54(3): 251-61, 2001
                                                                                              17. Jouvet A et al: Pineal parenchymal tumors: a correlation of histological features with prognosis in 66 cases. Brain Pathol. 10(1):49-60, 2000
                                                                                              18. Nakamura M et al: Neuroradiological characteristics of pineocytoma and pineoblastoma. Neuroradiology. 42(7):509-14, 2000