Less preferred terms include infundibuloma and posterior pituitary astrocytoma
Definitions
Rare tumor arising from pituicytes, specialized glial cells in neurohypophysis and infundibulum
Part of 2017 WHO spectrum of thyroid transcription factor-1 (TTF-1) expressing pituitary tumors of posterior lobe
IMAGING
General Features
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
Borg A et al: Tumors of the neurohypophysis: one unit's experience and literature review. World Neurosurg. 134:e968-78, 2020
McNamara KJ et al: A recurrent case of pituicytoma 16 years later. Ann R Coll Surg Engl. 1-3, 2020
Cole TS et al: Rare Thyroid Transcription Factor 1-Positive Tumors of the Sellar Region: Barrow Neurological Institute Retrospective Case Series. World Neurosurg. 129:e294-e302, 2019
Gezer E et al: The coexistence of infundibular pituicytoma and Cushing's disease due to pituitary adenoma: A case report. Endocr Regul. 53(4):263-267, 2019
Guerrero-Pérez F et al: Primary tumors of the posterior pituitary: A systematic review. Rev Endocr Metab Disord. 20(2):219-238, 2019
Guerrero-Pérez F et al: Posterior pituitary tumours: the spectrum of a unique entity. A clinical and histological study of a large case series. Endocrine. 63(1):36-43, 2019
Marco Del Pont F et al: Pituicytoma Associated with Acromegaly and Cushing Disease. World Neurosurg. 136:78-82, 2019
Lefevre E et al: Management of pituicytomas: a multicenter series of eight cases. Pituitary. ePub, 2018
Shibuya M: Welcoming the new WHO classification of pituitary tumors 2017: revolution in TTF-1-positive posterior pituitary tumors. Brain Tumor Pathol. 35(2):62-70, 2018
Lopes MBS: The 2017 World Health Organization classification of tumors of the pituitary gland: a summary. Acta Neuropathol. 134(4):521-535, 2017
Mete O et al: Overview of the 2017 WHO Classification of Pituitary Tumors. Endocr Pathol. 21(5): 507-14, 2018
Zygourakis CC et al: Pituicytomas and spindle cell oncocytomas: modern case series from the University of California, San Francisco. Pituitary. 18(1):150-8, 2015
Feng M et al: Surgical management of pituicytomas: case series and comprehensive literature review. Pituitary. 17(5):399-413, 2014
Teti C et al: Pituitary image: pituicytoma. Pituitary. ePub, 2014
Kleinschmidt-DeMasters BK et al: Update on hypophysitis and TTF-1 expressing sellar region masses. Brain Pathol. 23(5):495-514, 2013
Secci F et al: Pituicytomas: radiological findings, clinical behavior and surgical management. Acta Neurochir (Wien). 154(4):649-57; discussion 657, 2012
Covington MF et al: Pituicytoma, spindle cell oncocytoma, and granular cell tumor: clarification and meta-analysis of the world literature since 1893. AJNR Am J Neuroradiol. 32(11):2067-72, 2011
Brat DJ et al: Newly codified glial neoplasms of the 2007 WHO Classification of Tumours of the Central Nervous System: angiocentric glioma, pilomyxoid astrocytoma and pituicytoma. Brain Pathol. 17(3):319-24, 2007
Louis DN et al: The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 2007 Aug;114(2):97-109. Epub 2007 Jul 6. Review. Erratum in: Acta Neuropathol. 114(5):547, 2007
Wesseling et al: Pituicytoma. In Louis DN et al (eds): WHO Classification of Tumours of the Central Nervous System. Lyon, France: IARC Press. 243-4, 2007
Benveniste RJ et al: Pituicytoma presenting with spontaneous hemorrhage. Pituitary. 9(1):53-8, 2006
Gibbs WN et al: Pituicytoma: diagnostic features on selective carotid angiography and MR imaging. AJNR Am J Neuroradiol. 27(8):1639-42, 2006
Takei H et al: Pituicytoma incidentally found at autopsy. Pathol Int. 55(11):745-9, 2005
Ulm AJ et al: Pituicytoma: report of two cases and clues regarding histogenesis. Neurosurgery. 2004 Mar;54(3):753-7; discussion 757-8. Erratum in: Neurosurgery. 54(5):1252, 2004
Katsuta T et al: Distinctions between pituicytoma and ordinary pilocytic astrocytoma. Case report. J Neurosurg. 98(2):404-6, 2003
Figarella-Branger D et al: Pituicytomas, a mis-diagnosed benign tumor of the neurohypophysis: report of three cases. Acta Neuropathol. 104(3):313-9, 2002
Brat DJ et al: Pituicytoma: a distinctive low-grade glioma of the neurohypophysis. Am J Surg Pathol. 24(3):362-8, 2000
WHO classification of tumours of the central nervous system, revised WK Cavenee, S Leung, C Hawkins, EG Van Meir… - World Health Organization, 2016
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TERMINOLOGY
Synonyms
Less preferred terms include infundibuloma and posterior pituitary astrocytoma
Definitions
Rare tumor arising from pituicytes, specialized glial cells in neurohypophysis and infundibulum
Part of 2017 WHO spectrum of thyroid transcription factor-1 (TTF-1) expressing pituitary tumors of posterior lobe
IMAGING
General Features
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
Borg A et al: Tumors of the neurohypophysis: one unit's experience and literature review. World Neurosurg. 134:e968-78, 2020
McNamara KJ et al: A recurrent case of pituicytoma 16 years later. Ann R Coll Surg Engl. 1-3, 2020
Cole TS et al: Rare Thyroid Transcription Factor 1-Positive Tumors of the Sellar Region: Barrow Neurological Institute Retrospective Case Series. World Neurosurg. 129:e294-e302, 2019
Gezer E et al: The coexistence of infundibular pituicytoma and Cushing's disease due to pituitary adenoma: A case report. Endocr Regul. 53(4):263-267, 2019
Guerrero-Pérez F et al: Primary tumors of the posterior pituitary: A systematic review. Rev Endocr Metab Disord. 20(2):219-238, 2019
Guerrero-Pérez F et al: Posterior pituitary tumours: the spectrum of a unique entity. A clinical and histological study of a large case series. Endocrine. 63(1):36-43, 2019
Marco Del Pont F et al: Pituicytoma Associated with Acromegaly and Cushing Disease. World Neurosurg. 136:78-82, 2019
Lefevre E et al: Management of pituicytomas: a multicenter series of eight cases. Pituitary. ePub, 2018
Shibuya M: Welcoming the new WHO classification of pituitary tumors 2017: revolution in TTF-1-positive posterior pituitary tumors. Brain Tumor Pathol. 35(2):62-70, 2018
Lopes MBS: The 2017 World Health Organization classification of tumors of the pituitary gland: a summary. Acta Neuropathol. 134(4):521-535, 2017
Mete O et al: Overview of the 2017 WHO Classification of Pituitary Tumors. Endocr Pathol. 21(5): 507-14, 2018
Zygourakis CC et al: Pituicytomas and spindle cell oncocytomas: modern case series from the University of California, San Francisco. Pituitary. 18(1):150-8, 2015
Feng M et al: Surgical management of pituicytomas: case series and comprehensive literature review. Pituitary. 17(5):399-413, 2014
Teti C et al: Pituitary image: pituicytoma. Pituitary. ePub, 2014
Kleinschmidt-DeMasters BK et al: Update on hypophysitis and TTF-1 expressing sellar region masses. Brain Pathol. 23(5):495-514, 2013
Secci F et al: Pituicytomas: radiological findings, clinical behavior and surgical management. Acta Neurochir (Wien). 154(4):649-57; discussion 657, 2012
Covington MF et al: Pituicytoma, spindle cell oncocytoma, and granular cell tumor: clarification and meta-analysis of the world literature since 1893. AJNR Am J Neuroradiol. 32(11):2067-72, 2011
Brat DJ et al: Newly codified glial neoplasms of the 2007 WHO Classification of Tumours of the Central Nervous System: angiocentric glioma, pilomyxoid astrocytoma and pituicytoma. Brain Pathol. 17(3):319-24, 2007
Louis DN et al: The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 2007 Aug;114(2):97-109. Epub 2007 Jul 6. Review. Erratum in: Acta Neuropathol. 114(5):547, 2007
Wesseling et al: Pituicytoma. In Louis DN et al (eds): WHO Classification of Tumours of the Central Nervous System. Lyon, France: IARC Press. 243-4, 2007
Benveniste RJ et al: Pituicytoma presenting with spontaneous hemorrhage. Pituitary. 9(1):53-8, 2006
Gibbs WN et al: Pituicytoma: diagnostic features on selective carotid angiography and MR imaging. AJNR Am J Neuroradiol. 27(8):1639-42, 2006
Takei H et al: Pituicytoma incidentally found at autopsy. Pathol Int. 55(11):745-9, 2005
Ulm AJ et al: Pituicytoma: report of two cases and clues regarding histogenesis. Neurosurgery. 2004 Mar;54(3):753-7; discussion 757-8. Erratum in: Neurosurgery. 54(5):1252, 2004
Katsuta T et al: Distinctions between pituicytoma and ordinary pilocytic astrocytoma. Case report. J Neurosurg. 98(2):404-6, 2003
Figarella-Branger D et al: Pituicytomas, a mis-diagnosed benign tumor of the neurohypophysis: report of three cases. Acta Neuropathol. 104(3):313-9, 2002
Brat DJ et al: Pituicytoma: a distinctive low-grade glioma of the neurohypophysis. Am J Surg Pathol. 24(3):362-8, 2000
WHO classification of tumours of the central nervous system, revised WK Cavenee, S Leung, C Hawkins, EG Van Meir… - World Health Organization, 2016
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