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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Synonyms
- Less preferred terms include infundibuloma and posterior pituitary astrocytoma
Definitions
- Rare tumor arising from pituicytes, specialized glial cells in neurohypophysis and infundibulum
- Part of 2017 WHO spectrum of thyroid transcription factor-1 (TTF-1) expressing pituitary tumors of posterior lobe
IMAGING
General Features
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
- Borg A et al: Tumors of the neurohypophysis: one unit's experience and literature review. World Neurosurg. 134:e968-78, 2020
- McNamara KJ et al: A recurrent case of pituicytoma 16 years later. Ann R Coll Surg Engl. 1-3, 2020
- Cole TS et al: Rare Thyroid Transcription Factor 1-Positive Tumors of the Sellar Region: Barrow Neurological Institute Retrospective Case Series. World Neurosurg. 129:e294-e302, 2019
- Gezer E et al: The coexistence of infundibular pituicytoma and Cushing's disease due to pituitary adenoma: A case report. Endocr Regul. 53(4):263-267, 2019
- Guerrero-Pérez F et al: Primary tumors of the posterior pituitary: A systematic review. Rev Endocr Metab Disord. 20(2):219-238, 2019
- Guerrero-Pérez F et al: Posterior pituitary tumours: the spectrum of a unique entity. A clinical and histological study of a large case series. Endocrine. 63(1):36-43, 2019
- Marco Del Pont F et al: Pituicytoma Associated with Acromegaly and Cushing Disease. World Neurosurg. 136:78-82, 2019
- Lefevre E et al: Management of pituicytomas: a multicenter series of eight cases. Pituitary. ePub, 2018
- Shibuya M: Welcoming the new WHO classification of pituitary tumors 2017: revolution in TTF-1-positive posterior pituitary tumors. Brain Tumor Pathol. 35(2):62-70, 2018
- Lopes MBS: The 2017 World Health Organization classification of tumors of the pituitary gland: a summary. Acta Neuropathol. 134(4):521-535, 2017
- Mete O et al: Overview of the 2017 WHO Classification of Pituitary Tumors. Endocr Pathol. 21(5): 507-14, 2018
- Zygourakis CC et al: Pituicytomas and spindle cell oncocytomas: modern case series from the University of California, San Francisco. Pituitary. 18(1):150-8, 2015
- Feng M et al: Surgical management of pituicytomas: case series and comprehensive literature review. Pituitary. 17(5):399-413, 2014
- Teti C et al: Pituitary image: pituicytoma. Pituitary. ePub, 2014
- Kleinschmidt-DeMasters BK et al: Update on hypophysitis and TTF-1 expressing sellar region masses. Brain Pathol. 23(5):495-514, 2013
- Secci F et al: Pituicytomas: radiological findings, clinical behavior and surgical management. Acta Neurochir (Wien). 154(4):649-57; discussion 657, 2012
- Covington MF et al: Pituicytoma, spindle cell oncocytoma, and granular cell tumor: clarification and meta-analysis of the world literature since 1893. AJNR Am J Neuroradiol. 32(11):2067-72, 2011
- Brat DJ et al: Newly codified glial neoplasms of the 2007 WHO Classification of Tumours of the Central Nervous System: angiocentric glioma, pilomyxoid astrocytoma and pituicytoma. Brain Pathol. 17(3):319-24, 2007
- Louis DN et al: The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 2007 Aug;114(2):97-109. Epub 2007 Jul 6. Review. Erratum in: Acta Neuropathol. 114(5):547, 2007
- Wesseling et al: Pituicytoma. In Louis DN et al (eds): WHO Classification of Tumours of the Central Nervous System. Lyon, France: IARC Press. 243-4, 2007
- Benveniste RJ et al: Pituicytoma presenting with spontaneous hemorrhage. Pituitary. 9(1):53-8, 2006
- Gibbs WN et al: Pituicytoma: diagnostic features on selective carotid angiography and MR imaging. AJNR Am J Neuroradiol. 27(8):1639-42, 2006
- Takei H et al: Pituicytoma incidentally found at autopsy. Pathol Int. 55(11):745-9, 2005
- Ulm AJ et al: Pituicytoma: report of two cases and clues regarding histogenesis. Neurosurgery. 2004 Mar;54(3):753-7; discussion 757-8. Erratum in: Neurosurgery. 54(5):1252, 2004
- Katsuta T et al: Distinctions between pituicytoma and ordinary pilocytic astrocytoma. Case report. J Neurosurg. 98(2):404-6, 2003
- Figarella-Branger D et al: Pituicytomas, a mis-diagnosed benign tumor of the neurohypophysis: report of three cases. Acta Neuropathol. 104(3):313-9, 2002
- Brat DJ et al: Pituicytoma: a distinctive low-grade glioma of the neurohypophysis. Am J Surg Pathol. 24(3):362-8, 2000
- WHO classification of tumours of the central nervous system, revised WK Cavenee, S Leung, C Hawkins, EG Van Meir… - World Health Organization, 2016
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Synonyms
- Less preferred terms include infundibuloma and posterior pituitary astrocytoma
Definitions
- Rare tumor arising from pituicytes, specialized glial cells in neurohypophysis and infundibulum
- Part of 2017 WHO spectrum of thyroid transcription factor-1 (TTF-1) expressing pituitary tumors of posterior lobe
IMAGING
General Features
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
- Borg A et al: Tumors of the neurohypophysis: one unit's experience and literature review. World Neurosurg. 134:e968-78, 2020
- McNamara KJ et al: A recurrent case of pituicytoma 16 years later. Ann R Coll Surg Engl. 1-3, 2020
- Cole TS et al: Rare Thyroid Transcription Factor 1-Positive Tumors of the Sellar Region: Barrow Neurological Institute Retrospective Case Series. World Neurosurg. 129:e294-e302, 2019
- Gezer E et al: The coexistence of infundibular pituicytoma and Cushing's disease due to pituitary adenoma: A case report. Endocr Regul. 53(4):263-267, 2019
- Guerrero-Pérez F et al: Primary tumors of the posterior pituitary: A systematic review. Rev Endocr Metab Disord. 20(2):219-238, 2019
- Guerrero-Pérez F et al: Posterior pituitary tumours: the spectrum of a unique entity. A clinical and histological study of a large case series. Endocrine. 63(1):36-43, 2019
- Marco Del Pont F et al: Pituicytoma Associated with Acromegaly and Cushing Disease. World Neurosurg. 136:78-82, 2019
- Lefevre E et al: Management of pituicytomas: a multicenter series of eight cases. Pituitary. ePub, 2018
- Shibuya M: Welcoming the new WHO classification of pituitary tumors 2017: revolution in TTF-1-positive posterior pituitary tumors. Brain Tumor Pathol. 35(2):62-70, 2018
- Lopes MBS: The 2017 World Health Organization classification of tumors of the pituitary gland: a summary. Acta Neuropathol. 134(4):521-535, 2017
- Mete O et al: Overview of the 2017 WHO Classification of Pituitary Tumors. Endocr Pathol. 21(5): 507-14, 2018
- Zygourakis CC et al: Pituicytomas and spindle cell oncocytomas: modern case series from the University of California, San Francisco. Pituitary. 18(1):150-8, 2015
- Feng M et al: Surgical management of pituicytomas: case series and comprehensive literature review. Pituitary. 17(5):399-413, 2014
- Teti C et al: Pituitary image: pituicytoma. Pituitary. ePub, 2014
- Kleinschmidt-DeMasters BK et al: Update on hypophysitis and TTF-1 expressing sellar region masses. Brain Pathol. 23(5):495-514, 2013
- Secci F et al: Pituicytomas: radiological findings, clinical behavior and surgical management. Acta Neurochir (Wien). 154(4):649-57; discussion 657, 2012
- Covington MF et al: Pituicytoma, spindle cell oncocytoma, and granular cell tumor: clarification and meta-analysis of the world literature since 1893. AJNR Am J Neuroradiol. 32(11):2067-72, 2011
- Brat DJ et al: Newly codified glial neoplasms of the 2007 WHO Classification of Tumours of the Central Nervous System: angiocentric glioma, pilomyxoid astrocytoma and pituicytoma. Brain Pathol. 17(3):319-24, 2007
- Louis DN et al: The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 2007 Aug;114(2):97-109. Epub 2007 Jul 6. Review. Erratum in: Acta Neuropathol. 114(5):547, 2007
- Wesseling et al: Pituicytoma. In Louis DN et al (eds): WHO Classification of Tumours of the Central Nervous System. Lyon, France: IARC Press. 243-4, 2007
- Benveniste RJ et al: Pituicytoma presenting with spontaneous hemorrhage. Pituitary. 9(1):53-8, 2006
- Gibbs WN et al: Pituicytoma: diagnostic features on selective carotid angiography and MR imaging. AJNR Am J Neuroradiol. 27(8):1639-42, 2006
- Takei H et al: Pituicytoma incidentally found at autopsy. Pathol Int. 55(11):745-9, 2005
- Ulm AJ et al: Pituicytoma: report of two cases and clues regarding histogenesis. Neurosurgery. 2004 Mar;54(3):753-7; discussion 757-8. Erratum in: Neurosurgery. 54(5):1252, 2004
- Katsuta T et al: Distinctions between pituicytoma and ordinary pilocytic astrocytoma. Case report. J Neurosurg. 98(2):404-6, 2003
- Figarella-Branger D et al: Pituicytomas, a mis-diagnosed benign tumor of the neurohypophysis: report of three cases. Acta Neuropathol. 104(3):313-9, 2002
- Brat DJ et al: Pituicytoma: a distinctive low-grade glioma of the neurohypophysis. Am J Surg Pathol. 24(3):362-8, 2000
- WHO classification of tumours of the central nervous system, revised WK Cavenee, S Leung, C Hawkins, EG Van Meir… - World Health Organization, 2016
