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Pituitary Hyperplasia
Luke N. Ledbetter, MD; Anne G. Osborn, MD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          TERMINOLOGY

          • Definitions

            • Upper limit of normal pituitary height varies with age, gender
              • Pregnant/lactating females: 12 mm
              • Young menstruating females: 10 mm
              • Males, postmenopausal females: 8 mm
              • Infants, children: 6 mm
            • Nonphysiologic hyperplasia seen with
              • Longstanding hypothyroidism, Addison disease, end-organ failure, or some neuroendocrine neoplasms

          IMAGING

          • General Features

            • CT Findings

              • MR Findings

                • Imaging Recommendations

                  DIFFERENTIAL DIAGNOSIS

                    PATHOLOGY

                    • General Features

                      • Microscopic Features

                        CLINICAL ISSUES

                        • Presentation

                          • Demographics

                            • Treatment

                              DIAGNOSTIC CHECKLIST

                              • Consider

                                Selected References

                                1. Winters SJ et al: Addison's Disease and Pituitary Enlargement. Am J Med Sci. 349(6):526-9, 2015
                                2. Gläsker S et al: Hereditary pituitary hyperplasia with infantile gigantism. J Clin Endocrinol Metab. 96(12):E2078-87, 2011
                                3. Zhou J et al: Addison's disease with pituitary hyperplasia: a case report and review of the literature. Endocrine. 35(3):285-289, 2009
                                4. Alves C et al: Primary hypothyroidism in a child simulating a prolactin-secreting adenoma. Childs Nerv Syst. 24(12):1505-8, 2008
                                Related Anatomy
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                                Related Differential Diagnoses
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                                References
                                Tables

                                Tables

                                KEY FACTS

                                • Terminology

                                  • Imaging

                                    • Top Differential Diagnoses

                                      • Pathology

                                        TERMINOLOGY

                                        • Definitions

                                          • Upper limit of normal pituitary height varies with age, gender
                                            • Pregnant/lactating females: 12 mm
                                            • Young menstruating females: 10 mm
                                            • Males, postmenopausal females: 8 mm
                                            • Infants, children: 6 mm
                                          • Nonphysiologic hyperplasia seen with
                                            • Longstanding hypothyroidism, Addison disease, end-organ failure, or some neuroendocrine neoplasms

                                        IMAGING

                                        • General Features

                                          • CT Findings

                                            • MR Findings

                                              • Imaging Recommendations

                                                DIFFERENTIAL DIAGNOSIS

                                                  PATHOLOGY

                                                  • General Features

                                                    • Microscopic Features

                                                      CLINICAL ISSUES

                                                      • Presentation

                                                        • Demographics

                                                          • Treatment

                                                            DIAGNOSTIC CHECKLIST

                                                            • Consider

                                                              Selected References

                                                              1. Winters SJ et al: Addison's Disease and Pituitary Enlargement. Am J Med Sci. 349(6):526-9, 2015
                                                              2. Gläsker S et al: Hereditary pituitary hyperplasia with infantile gigantism. J Clin Endocrinol Metab. 96(12):E2078-87, 2011
                                                              3. Zhou J et al: Addison's disease with pituitary hyperplasia: a case report and review of the literature. Endocrine. 35(3):285-289, 2009
                                                              4. Alves C et al: Primary hypothyroidism in a child simulating a prolactin-secreting adenoma. Childs Nerv Syst. 24(12):1505-8, 2008