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Plasmacytoma and Multiple Myeloma
Brett W. Carter, MD, CPPS
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Solitary plasmacytoma of bone (SPB)
              • Extramedullary plasmacytoma (EMP)
              • Multiple myeloma (MM)
            • Definitions

              • SPB: Solitary plasma cell tumor of bone
                • No evidence of systemic disease
              • EMP: Solitary plasmacytoma arising in soft tissues
              • MM: Neoplastic proliferation of plasma cells
                • Monoclonal gammopathy; multiple bone lesions

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Nuclear Medicine Findings

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • Staging, Grading, & Classification

                          CLINICAL ISSUES

                          • Presentation

                            • Demographics

                              • Natural History & Prognosis

                                • Treatment

                                  Selected References

                                  1. Baffour FI et al: Role of imaging in multiple myeloma. Am J Hematol. 95(8):966-77, 2020
                                  2. Di Giuliano F et al: Radiological imaging in multiple myeloma: review of the state-of-the-art. Neuroradiology. 62(8):905-23, 2020
                                  3. Kosmala A et al: Imaging of multiple myeloma. Rofo. 191(9):805-16, 2019
                                  4. Mosebach J et al: Multiple myeloma guidelines and their recent updates: implications for imaging. Rofo. 191(11):998-1009, 2019
                                  5. Ormond Filho AG et al: Whole-body imaging of multiple myeloma: diagnostic criteria. Radiographics. 39(4):1077-97, 2019
                                  6. Shah SN et al: PET/MR imaging of multiple myeloma. Magn Reson Imaging Clin N Am. 25(2):351-65, 2017
                                  7. Hanrahan CJ et al: Current concepts in the evaluation of multiple myeloma with MR imaging and FDG PET/CT. Radiographics. 30(1):127-42, 2010
                                  8. Dores GM et al: Plasmacytoma of bone, extramedullary plasmacytoma, and multiple myeloma: incidence and survival in the United States, 1992-2004. Br J Haematol. 144(1):86-94, 2009
                                  9. International Myeloma Working Group: Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. Br J Haematol. 121(5):749-57, 2003
                                  10. Tateishi U et al: Chest wall tumors: radiologic findings and pathologic correlation: part 2. Malignant tumors. Radiographics. 23(6):1491-508, 2003
                                  Related Anatomy
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                                  Related Differential Diagnoses
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                                  References
                                  Tables

                                  Tables

                                  KEY FACTS

                                  • Terminology

                                    • Imaging

                                      • Top Differential Diagnoses

                                        • Pathology

                                          • Clinical Issues

                                            TERMINOLOGY

                                            • Abbreviations

                                              • Solitary plasmacytoma of bone (SPB)
                                              • Extramedullary plasmacytoma (EMP)
                                              • Multiple myeloma (MM)
                                            • Definitions

                                              • SPB: Solitary plasma cell tumor of bone
                                                • No evidence of systemic disease
                                              • EMP: Solitary plasmacytoma arising in soft tissues
                                              • MM: Neoplastic proliferation of plasma cells
                                                • Monoclonal gammopathy; multiple bone lesions

                                            IMAGING

                                            • General Features

                                              • Radiographic Findings

                                                • CT Findings

                                                  • MR Findings

                                                    • Nuclear Medicine Findings

                                                      DIFFERENTIAL DIAGNOSIS

                                                        PATHOLOGY

                                                        • Staging, Grading, & Classification

                                                          CLINICAL ISSUES

                                                          • Presentation

                                                            • Demographics

                                                              • Natural History & Prognosis

                                                                • Treatment

                                                                  Selected References

                                                                  1. Baffour FI et al: Role of imaging in multiple myeloma. Am J Hematol. 95(8):966-77, 2020
                                                                  2. Di Giuliano F et al: Radiological imaging in multiple myeloma: review of the state-of-the-art. Neuroradiology. 62(8):905-23, 2020
                                                                  3. Kosmala A et al: Imaging of multiple myeloma. Rofo. 191(9):805-16, 2019
                                                                  4. Mosebach J et al: Multiple myeloma guidelines and their recent updates: implications for imaging. Rofo. 191(11):998-1009, 2019
                                                                  5. Ormond Filho AG et al: Whole-body imaging of multiple myeloma: diagnostic criteria. Radiographics. 39(4):1077-97, 2019
                                                                  6. Shah SN et al: PET/MR imaging of multiple myeloma. Magn Reson Imaging Clin N Am. 25(2):351-65, 2017
                                                                  7. Hanrahan CJ et al: Current concepts in the evaluation of multiple myeloma with MR imaging and FDG PET/CT. Radiographics. 30(1):127-42, 2010
                                                                  8. Dores GM et al: Plasmacytoma of bone, extramedullary plasmacytoma, and multiple myeloma: incidence and survival in the United States, 1992-2004. Br J Haematol. 144(1):86-94, 2009
                                                                  9. International Myeloma Working Group: Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. Br J Haematol. 121(5):749-57, 2003
                                                                  10. Tateishi U et al: Chest wall tumors: radiologic findings and pathologic correlation: part 2. Malignant tumors. Radiographics. 23(6):1491-508, 2003