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Plasmacytoma
B.J. Manaster, MD, PhD, FACR; Chris Hanrahan, MD, PhD
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KEY FACTS

  • Terminology

    • Imaging

      • Clinical Issues

        • Diagnostic Checklist

          TERMINOLOGY

          • Abbreviations

            • Solitary bone plasmacytoma (SBP)
            • Extramedullary plasmacytoma (EMP)
          • Definitions

            • Localized clonal proliferation of plasma cells
            • Solitary bone plasmacytoma
              • Clonal proliferation of plasma cells centered in bone marrow
            • Solitary extramedullary plasmacytoma
              • Clonal proliferation of plasma cells in extramedullary location
            • Extramedullary plasmacytoma in presence of multiple myeloma (MM)
              • MM with localized extramedullary clonal proliferation of plasma cells

          IMAGING

          • General Features

            • Imaging Recommendations

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Staging, Grading, & Classification

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Consider

                                      • Image Interpretation Pearls

                                        • Reporting Tips

                                          Selected References

                                          1. Dimopoulos MA et al: Role of Magnetic Resonance Imaging in the Management of Patients With Multiple Myeloma: A Consensus Statement. J Clin Oncol. ePub, 2015
                                          2. Wang Y et al: Pelvic solitary plasmacytoma: computed tomography and magnetic resonance imaging findings with histopathologic correlation. Korean J Radiol. 16(1):146-53, 2015
                                          3. Katodritou E et al: Clinical features, outcome, and prognostic factors for survival and evolution to multiple myeloma of solitary plasmacytomas: a report of the Greek myeloma study group in 97 patients. Am J Hematol. 89(8):803-8, 2014
                                          4. Paiva B et al: Multiparameter flow cytometry for staging of solitary bone plasmacytoma: new criteria for risk of progression to myeloma. Blood. 124(8):1300-3, 2014
                                          5. Guo SQ et al: Prognostic factors associated with solitary plasmacytoma. Onco Targets Ther. 6:1659-66, 2013
                                          6. Varettoni M et al: Incidence, presenting features and outcome of extramedullary disease in multiple myeloma: a longitudinal study on 1003 consecutive patients. Ann Oncol. 21(2):325-30, 2010
                                          7. Dores GM et al: Plasmacytoma of bone, extramedullary plasmacytoma, and multiple myeloma: incidence and survival in the United States, 1992-2004. Br J Haematol. 144(1):86-94, 2009
                                          8. Bink K et al: Primary extramedullary plasmacytoma: similarities with and differences from multiple myeloma revealed by interphase cytogenetics. Haematologica. 93(4):623-6, 2008
                                          9. Kumar S: Solitary plasmacytoma: is radiation therapy sufficient? Am J Hematol. 83(9):695-6, 2008
                                          10. Knobel D et al: Prognostic factors in solitary plasmacytoma of the bone: a multicenter Rare Cancer Network study. BMC Cancer. 6:118, 2006
                                          11. Ozsahin M et al: Outcomes and patterns of failure in solitary plasmacytoma: a multicenter Rare Cancer Network study of 258 patients. Int J Radiat Oncol Biol Phys. 64(1):210-7, 2006
                                          12. Soutar R et al: Guidelines on the diagnosis and management of solitary plasmacytoma of bone and solitary extramedullary plasmacytoma. Br J Haematol. 124(6):717-26, 2004
                                          13. Dimopoulos MA et al: Solitary plasmacytoma of bone and extramedullary plasmacytoma. Hematol Oncol Clin North Am. 13(6):1249-57, 1999
                                          14. Moulopoulos LA et al: Extraosseous multiple myeloma: imaging features. AJR Am J Roentgenol. 161(5):1083-7, 1993
                                          15. Knowling MA et al: Comparison of extramedullary plasmacytomas with solitary and multiple plasma cell tumors of bone. J Clin Oncol. 1(4):255-62, 1983
                                          16. Bush SE et al: Extramedullary plasmacytoma of the head and neck. Radiology. 140(3):801-5, 1981
                                          17. Wiltshaw E: The natural history of extramedullary plasmacytoma and its relation to solitary myeloma of bone and myelomatosis. Medicine (Baltimore). 55(3):217-38, 1976
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Clinical Issues

                                                • Diagnostic Checklist

                                                  TERMINOLOGY

                                                  • Abbreviations

                                                    • Solitary bone plasmacytoma (SBP)
                                                    • Extramedullary plasmacytoma (EMP)
                                                  • Definitions

                                                    • Localized clonal proliferation of plasma cells
                                                    • Solitary bone plasmacytoma
                                                      • Clonal proliferation of plasma cells centered in bone marrow
                                                    • Solitary extramedullary plasmacytoma
                                                      • Clonal proliferation of plasma cells in extramedullary location
                                                    • Extramedullary plasmacytoma in presence of multiple myeloma (MM)
                                                      • MM with localized extramedullary clonal proliferation of plasma cells

                                                  IMAGING

                                                  • General Features

                                                    • Imaging Recommendations

                                                      • Radiographic Findings

                                                        • CT Findings

                                                          • MR Findings

                                                            DIFFERENTIAL DIAGNOSIS

                                                              PATHOLOGY

                                                              • General Features

                                                                • Staging, Grading, & Classification

                                                                  • Microscopic Features

                                                                    CLINICAL ISSUES

                                                                    • Presentation

                                                                      • Demographics

                                                                        • Natural History & Prognosis

                                                                          • Treatment

                                                                            DIAGNOSTIC CHECKLIST

                                                                            • Consider

                                                                              • Image Interpretation Pearls

                                                                                • Reporting Tips

                                                                                  Selected References

                                                                                  1. Dimopoulos MA et al: Role of Magnetic Resonance Imaging in the Management of Patients With Multiple Myeloma: A Consensus Statement. J Clin Oncol. ePub, 2015
                                                                                  2. Wang Y et al: Pelvic solitary plasmacytoma: computed tomography and magnetic resonance imaging findings with histopathologic correlation. Korean J Radiol. 16(1):146-53, 2015
                                                                                  3. Katodritou E et al: Clinical features, outcome, and prognostic factors for survival and evolution to multiple myeloma of solitary plasmacytomas: a report of the Greek myeloma study group in 97 patients. Am J Hematol. 89(8):803-8, 2014
                                                                                  4. Paiva B et al: Multiparameter flow cytometry for staging of solitary bone plasmacytoma: new criteria for risk of progression to myeloma. Blood. 124(8):1300-3, 2014
                                                                                  5. Guo SQ et al: Prognostic factors associated with solitary plasmacytoma. Onco Targets Ther. 6:1659-66, 2013
                                                                                  6. Varettoni M et al: Incidence, presenting features and outcome of extramedullary disease in multiple myeloma: a longitudinal study on 1003 consecutive patients. Ann Oncol. 21(2):325-30, 2010
                                                                                  7. Dores GM et al: Plasmacytoma of bone, extramedullary plasmacytoma, and multiple myeloma: incidence and survival in the United States, 1992-2004. Br J Haematol. 144(1):86-94, 2009
                                                                                  8. Bink K et al: Primary extramedullary plasmacytoma: similarities with and differences from multiple myeloma revealed by interphase cytogenetics. Haematologica. 93(4):623-6, 2008
                                                                                  9. Kumar S: Solitary plasmacytoma: is radiation therapy sufficient? Am J Hematol. 83(9):695-6, 2008
                                                                                  10. Knobel D et al: Prognostic factors in solitary plasmacytoma of the bone: a multicenter Rare Cancer Network study. BMC Cancer. 6:118, 2006
                                                                                  11. Ozsahin M et al: Outcomes and patterns of failure in solitary plasmacytoma: a multicenter Rare Cancer Network study of 258 patients. Int J Radiat Oncol Biol Phys. 64(1):210-7, 2006
                                                                                  12. Soutar R et al: Guidelines on the diagnosis and management of solitary plasmacytoma of bone and solitary extramedullary plasmacytoma. Br J Haematol. 124(6):717-26, 2004
                                                                                  13. Dimopoulos MA et al: Solitary plasmacytoma of bone and extramedullary plasmacytoma. Hematol Oncol Clin North Am. 13(6):1249-57, 1999
                                                                                  14. Moulopoulos LA et al: Extraosseous multiple myeloma: imaging features. AJR Am J Roentgenol. 161(5):1083-7, 1993
                                                                                  15. Knowling MA et al: Comparison of extramedullary plasmacytomas with solitary and multiple plasma cell tumors of bone. J Clin Oncol. 1(4):255-62, 1983
                                                                                  16. Bush SE et al: Extramedullary plasmacytoma of the head and neck. Radiology. 140(3):801-5, 1981
                                                                                  17. Wiltshaw E: The natural history of extramedullary plasmacytoma and its relation to solitary myeloma of bone and myelomatosis. Medicine (Baltimore). 55(3):217-38, 1976