No anemia, hypercalcemia, or renal involvement suggesting systemic myeloma
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nonvascular Interventions
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Wang Y et al: Solitary plasmacytoma of bone of the spine: results from surveillance, epidemiology, and end results (SEER) registry. Spine (Phila Pa 1976). 44(2):E117-25, 2019
Caers J et al: Diagnosis, treatment, and response assessment in solitary plasmacytoma: updated recommendations from a European Expert Panel. J Hematol Oncol. 11(1):10, 2018
Dimopoulos MA et al: Role of magnetic resonance imaging in the management of patients with multiple myeloma: a consensus statement. J Clin Oncol. 33(6):657-64, 2015
Song IC et al: Diagnostic and prognostic implications of spine magnetic resonance imaging at diagnosis in patients with multiple myeloma. Cancer Res Treat. 47(3):465-72, 2014
Yang JS et al: Rapid progression of solitary plasmacytoma to multiple myeloma in lumbar vertebra. J Korean Neurosurg Soc. 54(5):426-30, 2013
Afonso PD et al: Solitary plasmacytoma of the spine: an unusual presentation. AJNR Am J Neuroradiol. 31(1):E5, 2010
Huang W et al: Solitary plasmacytoma of cervical spine: treatment and prognosis in patients with neurological lesions and spinal instability. Spine (Phila Pa 1976). 35(8):E278-84, 2010
Zuo Z et al: [Solitary plasmacytoma of bone: a clinicopathologic, immunohistochemical and immunoglobulin gene rearrangement study.] Zhonghua Bing Li Xue Za Zhi. 39(3):177-82, 2010
Dingli D et al: Immunoglobulin free light chains and solitary plasmacytoma of bone. Blood. 108(6):1979-83, 2006
Kumar S et al: Prognostic value of angiogenesis in solitary bone plasmacytoma. Blood. 101(5):1715-7, 2003
Dimopoulos MA et al: Solitary bone plasmacytoma and extramedullary plasmacytoma. Curr Treat Options Oncol. 3(3):255-9, 2002
Durr HR et al: Multiple myeloma: surgery of the spine: retrospective analysis of 27 patients. Spine. 27(3):320-4; discussion 325-6, 2002
Gossios K et al: Solitary plasmacytoma of the spine in an adolescent: a case report. Pediatr Radiol. 32(5):366-9, 2002
Wilder RB et al: Persistence of myeloma protein for more than one year after radiotherapy is an adverse prognostic factor in solitary plasmacytoma of bone. Cancer. 94(5):1532-7, 2002
Alexandrakis MG et al: Value of Tc-99m sestamibi scintigraphy in the detection of bone lesions in multiple myeloma: comparison with Tc-99m methylene diphosphonate. Ann Hematol. 80(6):349-53, 2001
Avva R et al: CT-guided biopsy of focal lesions in patients with multiple myeloma may reveal new and more aggressive cytogenetic abnormalities. AJNR Am J Neuroradiol. 22(4):781-5, 2001
Ota K et al: A therapeutic strategy for isolated plasmacytoma of bone. J Int Med Res. 29(4):366-73, 2001
Soderlund V et al: Diagnosis of skeletal lymphoma and myeloma by radiology and fine needle aspiration cytology. Cytopathology. 12(3):157-67, 2001
Tsang RW et al: Solitary plasmacytoma treated with radiotherapy: impact of tumor size on outcome. Int J Radiat Oncol Biol Phys. 50(1):113-20, 2001
Voss SD et al: Solitary osteosclerotic plasmacytoma: association with demyelinating polyneuropathy and amyloid deposition. Skeletal Radiol. 30(9):527-9, 2001
Dimopoulos MA et al: Solitary plasmacytoma of bone and asymptomatic multiple myeloma. Blood. 96(6):2037-44, 2000
Major NM et al: The "mini brain": plasmacytoma in a vertebral body on MR imaging. AJR Am J Roentgenol. 175(1):261-3, 2000
Shah BK et al: Magnetic resonance imaging of spinal plasmacytoma. Clin Radiol. 55(6):439-45, 2000
Liebross RH et al: Clinical course of solitary extramedullary plasmacytoma. Radiother Oncol. 52(3):245-9, 1999
Lecouvet FE et al: Vertebral compression fractures in multiple myeloma. Part I. Distribution and appearance at MR imaging. Radiology. 204(1):195-9, 1997
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Synonyms
Solitary bone plasmacytoma (SBP), solitary myeloma, solitary plasma cell tumor
Definitions
Solitary monoclonal plasma cell tumor of bone or soft tissue without evidence of multiple myeloma (MM)
No anemia, hypercalcemia, or renal involvement suggesting systemic myeloma
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nonvascular Interventions
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Wang Y et al: Solitary plasmacytoma of bone of the spine: results from surveillance, epidemiology, and end results (SEER) registry. Spine (Phila Pa 1976). 44(2):E117-25, 2019
Caers J et al: Diagnosis, treatment, and response assessment in solitary plasmacytoma: updated recommendations from a European Expert Panel. J Hematol Oncol. 11(1):10, 2018
Dimopoulos MA et al: Role of magnetic resonance imaging in the management of patients with multiple myeloma: a consensus statement. J Clin Oncol. 33(6):657-64, 2015
Song IC et al: Diagnostic and prognostic implications of spine magnetic resonance imaging at diagnosis in patients with multiple myeloma. Cancer Res Treat. 47(3):465-72, 2014
Yang JS et al: Rapid progression of solitary plasmacytoma to multiple myeloma in lumbar vertebra. J Korean Neurosurg Soc. 54(5):426-30, 2013
Afonso PD et al: Solitary plasmacytoma of the spine: an unusual presentation. AJNR Am J Neuroradiol. 31(1):E5, 2010
Huang W et al: Solitary plasmacytoma of cervical spine: treatment and prognosis in patients with neurological lesions and spinal instability. Spine (Phila Pa 1976). 35(8):E278-84, 2010
Zuo Z et al: [Solitary plasmacytoma of bone: a clinicopathologic, immunohistochemical and immunoglobulin gene rearrangement study.] Zhonghua Bing Li Xue Za Zhi. 39(3):177-82, 2010
Dingli D et al: Immunoglobulin free light chains and solitary plasmacytoma of bone. Blood. 108(6):1979-83, 2006
Kumar S et al: Prognostic value of angiogenesis in solitary bone plasmacytoma. Blood. 101(5):1715-7, 2003
Dimopoulos MA et al: Solitary bone plasmacytoma and extramedullary plasmacytoma. Curr Treat Options Oncol. 3(3):255-9, 2002
Durr HR et al: Multiple myeloma: surgery of the spine: retrospective analysis of 27 patients. Spine. 27(3):320-4; discussion 325-6, 2002
Gossios K et al: Solitary plasmacytoma of the spine in an adolescent: a case report. Pediatr Radiol. 32(5):366-9, 2002
Wilder RB et al: Persistence of myeloma protein for more than one year after radiotherapy is an adverse prognostic factor in solitary plasmacytoma of bone. Cancer. 94(5):1532-7, 2002
Alexandrakis MG et al: Value of Tc-99m sestamibi scintigraphy in the detection of bone lesions in multiple myeloma: comparison with Tc-99m methylene diphosphonate. Ann Hematol. 80(6):349-53, 2001
Avva R et al: CT-guided biopsy of focal lesions in patients with multiple myeloma may reveal new and more aggressive cytogenetic abnormalities. AJNR Am J Neuroradiol. 22(4):781-5, 2001
Ota K et al: A therapeutic strategy for isolated plasmacytoma of bone. J Int Med Res. 29(4):366-73, 2001
Soderlund V et al: Diagnosis of skeletal lymphoma and myeloma by radiology and fine needle aspiration cytology. Cytopathology. 12(3):157-67, 2001
Tsang RW et al: Solitary plasmacytoma treated with radiotherapy: impact of tumor size on outcome. Int J Radiat Oncol Biol Phys. 50(1):113-20, 2001
Voss SD et al: Solitary osteosclerotic plasmacytoma: association with demyelinating polyneuropathy and amyloid deposition. Skeletal Radiol. 30(9):527-9, 2001
Dimopoulos MA et al: Solitary plasmacytoma of bone and asymptomatic multiple myeloma. Blood. 96(6):2037-44, 2000
Major NM et al: The "mini brain": plasmacytoma in a vertebral body on MR imaging. AJR Am J Roentgenol. 175(1):261-3, 2000
Shah BK et al: Magnetic resonance imaging of spinal plasmacytoma. Clin Radiol. 55(6):439-45, 2000
Liebross RH et al: Clinical course of solitary extramedullary plasmacytoma. Radiother Oncol. 52(3):245-9, 1999
Lecouvet FE et al: Vertebral compression fractures in multiple myeloma. Part I. Distribution and appearance at MR imaging. Radiology. 204(1):195-9, 1997
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