Pleomorphic, high-grade sarcoma with variable number of pleomorphic lipoblasts
No areas of atypical lipomatous tumor/well-differentiated liposarcoma or other lines of differentiation are present
Rarest and most aggressive subtype (~ 5-10% of liposarcomas)
Subtype
Epithelioid sarcoma (25%)
IMAGING
General Features
Radiographic Findings
MR Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Selected References
Pedeutour F et al: Pleomorphic liposarcoma. In Fletcher CDM et al: World Health Organization Classification of Tumours: Soft Tissue and Bone Tumours. 5th ed. IARC Press. 45-6, 2020
Anderson WJ et al: Pleomorphic liposarcoma: updates and current differential diagnosis. Semin Diagn Pathol. 36(2):122-8, 2019
Wortman JR et al: Neoadjuvant radiation in primary extremity liposarcoma: correlation of MRI features with histopathology. Eur Radiol. 26(5):1226-34, 2015
Kransdorf MJ et al: Lipomatous tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 3rd ed. Lippincott Williams & Wilkins. 167-9, 2014
Lee SA et al: Encapsulated fat necrosis mimicking subcutaneous liposarcoma: radiologic findings on MR, PET-CT, and US imaging. Skeletal Radiol. 42(10):1465-70, 2013
Shanbhogue AK et al: Uncommon primary pelvic retroperitoneal masses in adults: a pattern-based imaging approach. Radiographics. 32(3):795-817, 2012
Weiss SW et al: Liposarcoma. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Elsevier. 510, 2008
Murphey MD et al: From the archives of the AFIP: imaging of musculoskeletal liposarcoma with radiologic-pathologic correlation. Radiographics. 25(5):1371-95, 2005
Mentzel T et al: Pleomorphic liposarcoma. In Fletcher CDM et al: World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. IARC Press. 34-5, 2002
Related Anatomy
Loading...
Related Differential Diagnoses
Loading...
References
Tables
Tables
KEY FACTS
Terminology
Imaging
Clinical Issues
TERMINOLOGY
Definitions
Pleomorphic, high-grade sarcoma with variable number of pleomorphic lipoblasts
No areas of atypical lipomatous tumor/well-differentiated liposarcoma or other lines of differentiation are present
Rarest and most aggressive subtype (~ 5-10% of liposarcomas)
Subtype
Epithelioid sarcoma (25%)
IMAGING
General Features
Radiographic Findings
MR Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Selected References
Pedeutour F et al: Pleomorphic liposarcoma. In Fletcher CDM et al: World Health Organization Classification of Tumours: Soft Tissue and Bone Tumours. 5th ed. IARC Press. 45-6, 2020
Anderson WJ et al: Pleomorphic liposarcoma: updates and current differential diagnosis. Semin Diagn Pathol. 36(2):122-8, 2019
Wortman JR et al: Neoadjuvant radiation in primary extremity liposarcoma: correlation of MRI features with histopathology. Eur Radiol. 26(5):1226-34, 2015
Kransdorf MJ et al: Lipomatous tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 3rd ed. Lippincott Williams & Wilkins. 167-9, 2014
Lee SA et al: Encapsulated fat necrosis mimicking subcutaneous liposarcoma: radiologic findings on MR, PET-CT, and US imaging. Skeletal Radiol. 42(10):1465-70, 2013
Shanbhogue AK et al: Uncommon primary pelvic retroperitoneal masses in adults: a pattern-based imaging approach. Radiographics. 32(3):795-817, 2012
Weiss SW et al: Liposarcoma. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Elsevier. 510, 2008
Murphey MD et al: From the archives of the AFIP: imaging of musculoskeletal liposarcoma with radiologic-pathologic correlation. Radiographics. 25(5):1371-95, 2005
Mentzel T et al: Pleomorphic liposarcoma. In Fletcher CDM et al: World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. IARC Press. 34-5, 2002
STATdx includes over 200,000 searchable images, including x-ray, CT, MR, and ultrasound images. To access all images, please log in or subscribe.