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POEMS
B.J. Manaster, MD, PhD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Pathology

        • Clinical Issues

          TERMINOLOGY

          • Synonyms

            • Crow-Fukase syndrome, PEP (plasma cell dyscrasia, endocrinopathy, polyneuropathy), Takatsuki syndrome
          • Definitions

            • Polyneuropathy, organomegaly, endocrinopathy, M protein (monoclonal plasma cell proliferative disorder), skin changes (POEMS)
              • Acronym does not include several other important features; among them, sclerotic bone lesions

          IMAGING

          • General Features

            • Radiographic Findings

              • CT Findings

                • MR Findings

                  DIFFERENTIAL DIAGNOSIS

                    PATHOLOGY

                    • General Features

                      CLINICAL ISSUES

                      • Presentation

                        • Demographics

                          • Natural History & Prognosis

                            • Treatment

                              Selected References

                              1. Glazebrook K et al: Computed tomography assessment of bone lesions in patients with POEMS syndrome. Eur Radiol. 25(2):497-504, 2015
                              2. Shi X et al: CT characteristics in 24 patients with POEMS syndrome. Acta Radiol. ePub, 2015
                              3. Dispenzieri A: POEMS syndrome: 2014 update on diagnosis, risk-stratification, and management. Am J Hematol. 89(2):214-23, 2014
                              4. Ohwada C et al: Successful combination treatment with bevacizumab, thalidomide and autologous PBSC for severe POEMS syndrome. Bone Marrow Transplant. 43(9):739-40, 2009
                              5. Allam JS et al: Pulmonary manifestations in patients with POEMS syndrome: a retrospective review of 137 patients. Chest. 133(4):969-74, 2008
                              6. Kuwabara S et al: Neurologic improvement after peripheral blood stem cell transplantation in POEMS syndrome. Neurology. 71(21):1691-5, 2008
                              7. Silberman J et al: Review of peripheral neuropathy in plasma cell disorders. Hematol Oncol. 26(2):55-65, 2008
                              8. Dispenzieri A et al: POEMS syndrome: definitions and long-term outcome. Blood. 101(7):2496-506, 2003
                              9. Ishikawa O et al: The skin changes of POEMS syndrome. Br J Dermatol. 117(4):523-6, 1987
                              10. Resnick D et al: Plasma-cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes: the POEMS syndrome. Distinctive radiographic abnormalities. Radiology. 140(1):17-22, 1981
                              Related Anatomy
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                              Related Differential Diagnoses
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                              References
                              Tables

                              Tables

                              KEY FACTS

                              • Terminology

                                • Imaging

                                  • Pathology

                                    • Clinical Issues

                                      TERMINOLOGY

                                      • Synonyms

                                        • Crow-Fukase syndrome, PEP (plasma cell dyscrasia, endocrinopathy, polyneuropathy), Takatsuki syndrome
                                      • Definitions

                                        • Polyneuropathy, organomegaly, endocrinopathy, M protein (monoclonal plasma cell proliferative disorder), skin changes (POEMS)
                                          • Acronym does not include several other important features; among them, sclerotic bone lesions

                                      IMAGING

                                      • General Features

                                        • Radiographic Findings

                                          • CT Findings

                                            • MR Findings

                                              DIFFERENTIAL DIAGNOSIS

                                                PATHOLOGY

                                                • General Features

                                                  CLINICAL ISSUES

                                                  • Presentation

                                                    • Demographics

                                                      • Natural History & Prognosis

                                                        • Treatment

                                                          Selected References

                                                          1. Glazebrook K et al: Computed tomography assessment of bone lesions in patients with POEMS syndrome. Eur Radiol. 25(2):497-504, 2015
                                                          2. Shi X et al: CT characteristics in 24 patients with POEMS syndrome. Acta Radiol. ePub, 2015
                                                          3. Dispenzieri A: POEMS syndrome: 2014 update on diagnosis, risk-stratification, and management. Am J Hematol. 89(2):214-23, 2014
                                                          4. Ohwada C et al: Successful combination treatment with bevacizumab, thalidomide and autologous PBSC for severe POEMS syndrome. Bone Marrow Transplant. 43(9):739-40, 2009
                                                          5. Allam JS et al: Pulmonary manifestations in patients with POEMS syndrome: a retrospective review of 137 patients. Chest. 133(4):969-74, 2008
                                                          6. Kuwabara S et al: Neurologic improvement after peripheral blood stem cell transplantation in POEMS syndrome. Neurology. 71(21):1691-5, 2008
                                                          7. Silberman J et al: Review of peripheral neuropathy in plasma cell disorders. Hematol Oncol. 26(2):55-65, 2008
                                                          8. Dispenzieri A et al: POEMS syndrome: definitions and long-term outcome. Blood. 101(7):2496-506, 2003
                                                          9. Ishikawa O et al: The skin changes of POEMS syndrome. Br J Dermatol. 117(4):523-6, 1987
                                                          10. Resnick D et al: Plasma-cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes: the POEMS syndrome. Distinctive radiographic abnormalities. Radiology. 140(1):17-22, 1981