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Postcricoid Region Squamous Cell Carcinoma
Surjith Vattoth, MD, FRCR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Definitions

                • Postcricoid region of hypopharynx represents local mucosa and submucosal tissue dorsal to posterior portion of cricoid cartilage; this mucosal surface forms anterior wall of lower hypopharynx
                  • Mucosa extends superiorly from from level of arytenoid cartilages to inferior margin of cricoid
                  • 1 of 3 major subsites of hypopharynx that give rise to SCCa: Pyriform sinus, posterior hypopharyngeal wall, and postcricoid region

              IMAGING

              • Normal Anatomy of Postcricoid Region and Lower Hypopharynx

                • General Features

                  • CT Findings

                    • MR Findings

                      • Imaging Recommendations

                        • Nuclear Medicine Findings

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              • Staging, Grading, & Classification

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Image Interpretation Pearls

                                          Selected References

                                          1. Cho SJ et al: Comparison of diagnostic performance between CT and MRI for detection of cartilage invasion for primary tumor staging in patients with laryngo-hypopharyngeal cancer: a systematic review and meta-analysis. Eur Radiol. 30(7):3803-12, 2020
                                          2. Mo X et al: Prognostic value of the radiomics-based model in progression-free survival of hypopharyngeal cancer treated with chemoradiation. Eur Radiol. 30(2):833-43, 2020
                                          3. Bradley PJ et al: Open-neck organ preservation surgery for hypopharyngeal cancer: indications, techniques, limits, and outcomes. Curr Opin Otolaryngol Head Neck Surg. 27(2):123-9, 2019
                                          4. Dworkin JP et al: The role of the modified barium swallow study and esophagram in patients with globus sensation. Dysphagia. 30(5):506-10, 2015
                                          5. Chen AY et al: Pitfalls in the staging squamous cell carcinoma of the hypopharynx. Neuroimaging Clin N Am. 23(1):67-79, 2013
                                          6. Keereweer S et al: Chemoradiation for advanced hypopharyngeal carcinoma: a retrospective study on efficacy, morbidity and quality of life. Eur Arch Otorhinolaryngol. 269(3):939-46, 2012
                                          7. Joo YH et al: The impact of paratracheal lymph node metastasis in squamous cell carcinoma of the hypopharynx. Eur Arch Otorhinolaryngol. 267(6):945-50, 2010
                                          8. Hall SF et al: TNM-based stage groupings in head and neck cancer: application in cancer of the hypopharynx. Head Neck. 31(1):1-8, 2009
                                          9. Kamiyama R et al: Significance of retropharyngeal lymph node dissection in hypopharyngeal cancer. Jpn J Clin Oncol. 39(10):632-7, 2009
                                          10. Verduijn GM et al: Magnetic resonance imaging protocol optimization for delineation of gross tumor volume in hypopharyngeal and laryngeal tumors. Int J Radiat Oncol Biol Phys. 74(2):630-6, 2009
                                          11. Becker M et al: Imaging of the larynx and hypopharynx. Eur J Radiol. 66(3):460-79, 2008
                                          12. Becker M et al: Neoplastic invasion of laryngeal cartilage: reassessment of criteria for diagnosis at MR imaging. Radiology. 249(2):551-9, 2008
                                          13. Ng SH et al: Distant metastases and synchronous second primary tumors in patients with newly diagnosed oropharyngeal and hypopharyngeal carcinomas: evaluation of (18)F-FDG PET and extended-field multi-detector row CT. Neuroradiology. 50(11):969-79, 2008
                                          14. Sesterhenn AM et al: Cancer of the oro- and hypopharynx - when to expect recurrences? Acta Otolaryngol. 128(8):925-9, 2008
                                          15. Allen AM et al: Retropharyngeal nodes in hypopharynx cancer on positron emission tomography. J Clin Oncol. 25(5):599-601, 2007
                                          16. Roh JL et al: 2-[18F]-Fluoro-2-deoxy-D-glucose positron emission tomography as guidance for primary treatment in patients with advanced-stage resectable squamous cell carcinoma of the larynx and hypopharynx. Eur J Surg Oncol. 33(6):790-5, 2007
                                          17. Rumboldt Z et al: Imaging in head and neck cancer. Curr Treat Options Oncol. 7(1):23-34, 2006
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Pathology

                                                  • Clinical Issues

                                                    • Diagnostic Checklist

                                                      TERMINOLOGY

                                                      • Definitions

                                                        • Postcricoid region of hypopharynx represents local mucosa and submucosal tissue dorsal to posterior portion of cricoid cartilage; this mucosal surface forms anterior wall of lower hypopharynx
                                                          • Mucosa extends superiorly from from level of arytenoid cartilages to inferior margin of cricoid
                                                          • 1 of 3 major subsites of hypopharynx that give rise to SCCa: Pyriform sinus, posterior hypopharyngeal wall, and postcricoid region

                                                      IMAGING

                                                      • Normal Anatomy of Postcricoid Region and Lower Hypopharynx

                                                        • General Features

                                                          • CT Findings

                                                            • MR Findings

                                                              • Imaging Recommendations

                                                                • Nuclear Medicine Findings

                                                                  DIFFERENTIAL DIAGNOSIS

                                                                    PATHOLOGY

                                                                    • General Features

                                                                      • Staging, Grading, & Classification

                                                                        CLINICAL ISSUES

                                                                        • Presentation

                                                                          • Demographics

                                                                            • Natural History & Prognosis

                                                                              • Treatment

                                                                                DIAGNOSTIC CHECKLIST

                                                                                • Image Interpretation Pearls

                                                                                  Selected References

                                                                                  1. Cho SJ et al: Comparison of diagnostic performance between CT and MRI for detection of cartilage invasion for primary tumor staging in patients with laryngo-hypopharyngeal cancer: a systematic review and meta-analysis. Eur Radiol. 30(7):3803-12, 2020
                                                                                  2. Mo X et al: Prognostic value of the radiomics-based model in progression-free survival of hypopharyngeal cancer treated with chemoradiation. Eur Radiol. 30(2):833-43, 2020
                                                                                  3. Bradley PJ et al: Open-neck organ preservation surgery for hypopharyngeal cancer: indications, techniques, limits, and outcomes. Curr Opin Otolaryngol Head Neck Surg. 27(2):123-9, 2019
                                                                                  4. Dworkin JP et al: The role of the modified barium swallow study and esophagram in patients with globus sensation. Dysphagia. 30(5):506-10, 2015
                                                                                  5. Chen AY et al: Pitfalls in the staging squamous cell carcinoma of the hypopharynx. Neuroimaging Clin N Am. 23(1):67-79, 2013
                                                                                  6. Keereweer S et al: Chemoradiation for advanced hypopharyngeal carcinoma: a retrospective study on efficacy, morbidity and quality of life. Eur Arch Otorhinolaryngol. 269(3):939-46, 2012
                                                                                  7. Joo YH et al: The impact of paratracheal lymph node metastasis in squamous cell carcinoma of the hypopharynx. Eur Arch Otorhinolaryngol. 267(6):945-50, 2010
                                                                                  8. Hall SF et al: TNM-based stage groupings in head and neck cancer: application in cancer of the hypopharynx. Head Neck. 31(1):1-8, 2009
                                                                                  9. Kamiyama R et al: Significance of retropharyngeal lymph node dissection in hypopharyngeal cancer. Jpn J Clin Oncol. 39(10):632-7, 2009
                                                                                  10. Verduijn GM et al: Magnetic resonance imaging protocol optimization for delineation of gross tumor volume in hypopharyngeal and laryngeal tumors. Int J Radiat Oncol Biol Phys. 74(2):630-6, 2009
                                                                                  11. Becker M et al: Imaging of the larynx and hypopharynx. Eur J Radiol. 66(3):460-79, 2008
                                                                                  12. Becker M et al: Neoplastic invasion of laryngeal cartilage: reassessment of criteria for diagnosis at MR imaging. Radiology. 249(2):551-9, 2008
                                                                                  13. Ng SH et al: Distant metastases and synchronous second primary tumors in patients with newly diagnosed oropharyngeal and hypopharyngeal carcinomas: evaluation of (18)F-FDG PET and extended-field multi-detector row CT. Neuroradiology. 50(11):969-79, 2008
                                                                                  14. Sesterhenn AM et al: Cancer of the oro- and hypopharynx - when to expect recurrences? Acta Otolaryngol. 128(8):925-9, 2008
                                                                                  15. Allen AM et al: Retropharyngeal nodes in hypopharynx cancer on positron emission tomography. J Clin Oncol. 25(5):599-601, 2007
                                                                                  16. Roh JL et al: 2-[18F]-Fluoro-2-deoxy-D-glucose positron emission tomography as guidance for primary treatment in patients with advanced-stage resectable squamous cell carcinoma of the larynx and hypopharynx. Eur J Surg Oncol. 33(6):790-5, 2007
                                                                                  17. Rumboldt Z et al: Imaging in head and neck cancer. Curr Treat Options Oncol. 7(1):23-34, 2006