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Brain
Anatomy
Supratentorial Brain Anatomy
Posterior Cingulate Cortex (Areas 23, 31)
Posterior Cingulate Cortex (Areas 23, 31)
Jeffrey S. Anderson, MD, PhD; Jared A. Nielsen, PhD
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Location and Boundaries

  • Location

    • Boundaries

      Function

      • Self-Referential Cognition

        • Declarative Memory

          • Internal Narrative

            Structural Connections

            • Anterior Precuneus

              • Central Precuneus

                • Posterior Precuneus

                  • Ventral Posterior Cingulate

                    Functional Connections

                    • Coactive Regions

                      • Associated Literature Keywords (NeuroSynth)

                        Areas 23- and 31-Associated Disorders

                        • Alzheimer Dementia

                          • Epilepsy

                            • Autism, Down Syndrome, Schizophrenia

                              Selected References

                              1. Cunningham SI et al: Structural and functional connectivity of the precuneus and thalamus to the default mode network. Hum Brain Mapp. 38(2):938-56, 2017
                              2. Guterstam A et al: Posterior cingulate cortex integrates the senses of self-location and body ownership. Curr Biol. 25(11):1416-25, 2015
                              3. Mansouri FA et al: Behavioral consequences of selective damage to frontal pole and posterior cingulate cortices. Proc Natl Acad Sci U S A. 112(29):E3940-9, 2015
                              4. Khalsa S et al: The structural and functional connectivity of the posterior cingulate cortex: comparison between deterministic and probabilistic tractography for the investigation of structure-function relationships. Neuroimage. 102 Pt 1:118-27, 2014
                              5. Taylor VA et al: Impact of meditation training on the default mode network during a restful state. Soc Cogn Affect Neurosci. 8(1):4-14, 2013
                              6. Mars RB et al: On the relationship between the "default mode network" and the "social brain". Front Hum Neurosci. 6:189, 2012
                              7. Van Essen DC et al: Parcellations and hemispheric asymmetries of human cerebral cortex analyzed on surface-based atlases. Cereb Cortex. 22(10):2241-62, 2012
                              8. Anderson JS et al: Connectivity gradients between the default mode and attention control networks. Brain Connect. 1(2):147-57, 2011
                              9. Marcus DS et al: Informatics and data mining tools and strategies for the human connectome project. Front Neuroinform. 5:4, 2011
                              10. Petrella JR et al: Default mode network connectivity in stable vs progressive mild cognitive impairment. Neurology. 76(6):511-7, 2011
                              11. Andrews-Hanna JR et al: Functional-anatomic fractionation of the brain's default network. Neuron. 65(4):550-62, 2010
                              12. Greicius MD et al: Resting-state functional connectivity reflects structural connectivity in the default mode network. Cereb Cortex. 19(1):72-8, 2009
                              13. Margulies DS et al: Precuneus shares intrinsic functional architecture in humans and monkeys. Proc Natl Acad Sci U S A. 106(47):20069-74, 2009
                              14. Buckner RL et al: The brain's default network: anatomy, function, and relevance to disease. Ann N Y Acad Sci. 1124:1-38, 2008
                              15. Fransson P et al: The precuneus/posterior cingulate cortex plays a pivotal role in the default mode network: evidence from a partial correlation network analysis. Neuroimage. 42(3):1178-84, 2008
                              16. Cavanna AE et al: The precuneus: a review of its functional anatomy and behavioural correlates. Brain. 129(Pt 3):564-83, 2006
                              17. Greicius MD et al: Default-mode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI. Proc Natl Acad Sci U S A. 101(13):4637-42, 2004
                              18. Maldjian JA et al: An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Neuroimage. 19(3):1233-9, 2003
                              19. Raichle ME et al: A default mode of brain function. Proc Natl Acad Sci U S A. 98(2):676-82, 2001
                              Related Anatomy
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                              Related Differential Diagnoses
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                              References
                              Tables

                              Tables

                              Location and Boundaries

                              • Location

                                • Boundaries

                                  Function

                                  • Self-Referential Cognition

                                    • Declarative Memory

                                      • Internal Narrative

                                        Structural Connections

                                        • Anterior Precuneus

                                          • Central Precuneus

                                            • Posterior Precuneus

                                              • Ventral Posterior Cingulate

                                                Functional Connections

                                                • Coactive Regions

                                                  • Associated Literature Keywords (NeuroSynth)

                                                    Areas 23- and 31-Associated Disorders

                                                    • Alzheimer Dementia

                                                      • Epilepsy

                                                        • Autism, Down Syndrome, Schizophrenia

                                                          Selected References

                                                          1. Cunningham SI et al: Structural and functional connectivity of the precuneus and thalamus to the default mode network. Hum Brain Mapp. 38(2):938-56, 2017
                                                          2. Guterstam A et al: Posterior cingulate cortex integrates the senses of self-location and body ownership. Curr Biol. 25(11):1416-25, 2015
                                                          3. Mansouri FA et al: Behavioral consequences of selective damage to frontal pole and posterior cingulate cortices. Proc Natl Acad Sci U S A. 112(29):E3940-9, 2015
                                                          4. Khalsa S et al: The structural and functional connectivity of the posterior cingulate cortex: comparison between deterministic and probabilistic tractography for the investigation of structure-function relationships. Neuroimage. 102 Pt 1:118-27, 2014
                                                          5. Taylor VA et al: Impact of meditation training on the default mode network during a restful state. Soc Cogn Affect Neurosci. 8(1):4-14, 2013
                                                          6. Mars RB et al: On the relationship between the "default mode network" and the "social brain". Front Hum Neurosci. 6:189, 2012
                                                          7. Van Essen DC et al: Parcellations and hemispheric asymmetries of human cerebral cortex analyzed on surface-based atlases. Cereb Cortex. 22(10):2241-62, 2012
                                                          8. Anderson JS et al: Connectivity gradients between the default mode and attention control networks. Brain Connect. 1(2):147-57, 2011
                                                          9. Marcus DS et al: Informatics and data mining tools and strategies for the human connectome project. Front Neuroinform. 5:4, 2011
                                                          10. Petrella JR et al: Default mode network connectivity in stable vs progressive mild cognitive impairment. Neurology. 76(6):511-7, 2011
                                                          11. Andrews-Hanna JR et al: Functional-anatomic fractionation of the brain's default network. Neuron. 65(4):550-62, 2010
                                                          12. Greicius MD et al: Resting-state functional connectivity reflects structural connectivity in the default mode network. Cereb Cortex. 19(1):72-8, 2009
                                                          13. Margulies DS et al: Precuneus shares intrinsic functional architecture in humans and monkeys. Proc Natl Acad Sci U S A. 106(47):20069-74, 2009
                                                          14. Buckner RL et al: The brain's default network: anatomy, function, and relevance to disease. Ann N Y Acad Sci. 1124:1-38, 2008
                                                          15. Fransson P et al: The precuneus/posterior cingulate cortex plays a pivotal role in the default mode network: evidence from a partial correlation network analysis. Neuroimage. 42(3):1178-84, 2008
                                                          16. Cavanna AE et al: The precuneus: a review of its functional anatomy and behavioural correlates. Brain. 129(Pt 3):564-83, 2006
                                                          17. Greicius MD et al: Default-mode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI. Proc Natl Acad Sci U S A. 101(13):4637-42, 2004
                                                          18. Maldjian JA et al: An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Neuroimage. 19(3):1233-9, 2003
                                                          19. Raichle ME et al: A default mode of brain function. Proc Natl Acad Sci U S A. 98(2):676-82, 2001