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Posterior Oropharyngeal Wall Squamous Cell Carcinoma
Aparna Singhal, MD; Luke N. Ledbetter, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Definitions

                • Mucosal squamous cell carcinoma (SCCa) of posterior pharyngeal wall between soft palate & level of hyoid

              IMAGING

              • General Features

                • CT Findings

                  • MR Findings

                    • Nuclear Medicine Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Staging, Grading, & Classification

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Image Interpretation Pearls

                                          • Reporting Tips

                                            Selected References

                                            1. Hammarstedt L et al: The value of p16 and HPV DNA in non-tonsillar, non-base of tongue oropharyngeal cancer. Acta Otolaryngol. 141(1):89-94, 2021
                                            2. De Virgilio A et al: A systematic review of different treatment strategies for the squamous cell carcinoma of the posterior pharyngeal wall. Eur Arch Otorhinolaryngol. 277(10):2663-72, 2020
                                            3. Iyizoba-Ebozue Z et al: Incidence and patterns of retropharyngeal lymph node involvement in oropharyngeal carcinoma. Radiother Oncol. 142:92-9, 2020
                                            4. Marklund L et al: Survival of patients with oropharyngeal squamous cell carcinomas (OPSCC) in relation to TNM 8 - risk of incorrect downstaging of HPV-mediated non-tonsillar, non-base of tongue carcinomas. Eur J Cancer. 139:192-200, 2020
                                            5. Tham T et al: Anatomical subsite modifies survival in oropharyngeal squamous cell carcinoma: National Cancer Database study. Head Neck. 42(3):434-45, 2020
                                            6. Parvathaneni U et al: Advances in diagnosis and multidisciplinary management of oropharyngeal squamous cell carcinoma: state of the art. Radiographics. 39(7):2055-68, 2019
                                            7. Tham T et al: The prognostic effect of anatomic subsite in HPV-positive oropharyngeal squamous cell carcinoma. Am J Otolaryngol. 40(4):567-72, 2019
                                            8. Gelwan E et al: Nonuniform distribution of high-risk human papillomavirus in squamous cell carcinomas of the oropharynx: rethinking the anatomic boundaries of oral and oropharyngeal carcinoma from an oncologic HPV perspective. Am J Surg Pathol. 41(12):1722-8, 2017
                                            9. Canis M et al: Oncologic results of transoral laser microsurgery for squamous cell carcinoma of the posterior pharyngeal wall. Head Neck. 37(2):156-61, 2015
                                            10. De Felice F et al: Treatment of squamous cell carcinoma of the posterior pharyngeal wall: Radiotherapy versus surgery. Head Neck. 38 Suppl 1:E1722-9, 2015
                                            11. Corey A: Pitfalls in the staging of cancer of the oropharyngeal squamous cell carcinoma. Neuroimaging Clin N Am. 23(1):47-66, 2013
                                            12. Tshering Vogel DW et al: Cancer of the oral cavity and oropharynx. Cancer Imaging. 10:62-72, 2010
                                            13. Cohan DM et al: Oropharyngeal cancer: current understanding and management. Curr Opin Otolaryngol Head Neck Surg. 17(2):88-94, 2009
                                            14. Grant DG et al: Oropharyngeal cancer: a case for single modality treatment with transoral laser microsurgery. Arch Otolaryngol Head Neck Surg. 135(12):1225-30, 2009
                                            15. Shin HA et al: Role of primary surgery for early-stage (T1-2N0) squamous cell carcinoma of the oropharynx. Oral Oncol. 45(12):1063-6, 2009
                                            16. Stambuk HE et al: Oral cavity and oropharynx tumors. Radiol Clin North Am. 45(1):1-20, 2007
                                            17. Zima AJ et al: Magnetic resonance imaging of oropharyngeal cancer. Top Magn Reson Imaging. 18(4):237-42, 2007
                                            18. Shimizu K et al: Distribution and impact of lymph node metastases in oropharyngeal cancer. Acta Otolaryngol. 126(8):872-7, 2006
                                            19. Hsu WC et al: Accuracy of magnetic resonance imaging in predicting absence of fixation of head and neck cancer to the prevertebral space. Head Neck. 27(2):95-100, 2005
                                            20. Amin M.B. et al: AJCC Cancer Staging Manual. 8th Ed. Springer New York, 2017
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Pathology

                                                    • Clinical Issues

                                                      • Diagnostic Checklist

                                                        TERMINOLOGY

                                                        • Definitions

                                                          • Mucosal squamous cell carcinoma (SCCa) of posterior pharyngeal wall between soft palate & level of hyoid

                                                        IMAGING

                                                        • General Features

                                                          • CT Findings

                                                            • MR Findings

                                                              • Nuclear Medicine Findings

                                                                • Imaging Recommendations

                                                                  DIFFERENTIAL DIAGNOSIS

                                                                    PATHOLOGY

                                                                    • General Features

                                                                      • Staging, Grading, & Classification

                                                                        • Microscopic Features

                                                                          CLINICAL ISSUES

                                                                          • Presentation

                                                                            • Demographics

                                                                              • Natural History & Prognosis

                                                                                • Treatment

                                                                                  DIAGNOSTIC CHECKLIST

                                                                                  • Image Interpretation Pearls

                                                                                    • Reporting Tips

                                                                                      Selected References

                                                                                      1. Hammarstedt L et al: The value of p16 and HPV DNA in non-tonsillar, non-base of tongue oropharyngeal cancer. Acta Otolaryngol. 141(1):89-94, 2021
                                                                                      2. De Virgilio A et al: A systematic review of different treatment strategies for the squamous cell carcinoma of the posterior pharyngeal wall. Eur Arch Otorhinolaryngol. 277(10):2663-72, 2020
                                                                                      3. Iyizoba-Ebozue Z et al: Incidence and patterns of retropharyngeal lymph node involvement in oropharyngeal carcinoma. Radiother Oncol. 142:92-9, 2020
                                                                                      4. Marklund L et al: Survival of patients with oropharyngeal squamous cell carcinomas (OPSCC) in relation to TNM 8 - risk of incorrect downstaging of HPV-mediated non-tonsillar, non-base of tongue carcinomas. Eur J Cancer. 139:192-200, 2020
                                                                                      5. Tham T et al: Anatomical subsite modifies survival in oropharyngeal squamous cell carcinoma: National Cancer Database study. Head Neck. 42(3):434-45, 2020
                                                                                      6. Parvathaneni U et al: Advances in diagnosis and multidisciplinary management of oropharyngeal squamous cell carcinoma: state of the art. Radiographics. 39(7):2055-68, 2019
                                                                                      7. Tham T et al: The prognostic effect of anatomic subsite in HPV-positive oropharyngeal squamous cell carcinoma. Am J Otolaryngol. 40(4):567-72, 2019
                                                                                      8. Gelwan E et al: Nonuniform distribution of high-risk human papillomavirus in squamous cell carcinomas of the oropharynx: rethinking the anatomic boundaries of oral and oropharyngeal carcinoma from an oncologic HPV perspective. Am J Surg Pathol. 41(12):1722-8, 2017
                                                                                      9. Canis M et al: Oncologic results of transoral laser microsurgery for squamous cell carcinoma of the posterior pharyngeal wall. Head Neck. 37(2):156-61, 2015
                                                                                      10. De Felice F et al: Treatment of squamous cell carcinoma of the posterior pharyngeal wall: Radiotherapy versus surgery. Head Neck. 38 Suppl 1:E1722-9, 2015
                                                                                      11. Corey A: Pitfalls in the staging of cancer of the oropharyngeal squamous cell carcinoma. Neuroimaging Clin N Am. 23(1):47-66, 2013
                                                                                      12. Tshering Vogel DW et al: Cancer of the oral cavity and oropharynx. Cancer Imaging. 10:62-72, 2010
                                                                                      13. Cohan DM et al: Oropharyngeal cancer: current understanding and management. Curr Opin Otolaryngol Head Neck Surg. 17(2):88-94, 2009
                                                                                      14. Grant DG et al: Oropharyngeal cancer: a case for single modality treatment with transoral laser microsurgery. Arch Otolaryngol Head Neck Surg. 135(12):1225-30, 2009
                                                                                      15. Shin HA et al: Role of primary surgery for early-stage (T1-2N0) squamous cell carcinoma of the oropharynx. Oral Oncol. 45(12):1063-6, 2009
                                                                                      16. Stambuk HE et al: Oral cavity and oropharynx tumors. Radiol Clin North Am. 45(1):1-20, 2007
                                                                                      17. Zima AJ et al: Magnetic resonance imaging of oropharyngeal cancer. Top Magn Reson Imaging. 18(4):237-42, 2007
                                                                                      18. Shimizu K et al: Distribution and impact of lymph node metastases in oropharyngeal cancer. Acta Otolaryngol. 126(8):872-7, 2006
                                                                                      19. Hsu WC et al: Accuracy of magnetic resonance imaging in predicting absence of fixation of head and neck cancer to the prevertebral space. Head Neck. 27(2):95-100, 2005
                                                                                      20. Amin M.B. et al: AJCC Cancer Staging Manual. 8th Ed. Springer New York, 2017