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Posttransplant Lymphoproliferative Disease
Alexander J. Towbin, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Pathology

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Posttransplant lymphoproliferative disease (PTLD)
          • Definitions

            • Spectrum of abnormal lymphoid proliferation in transplant patients

          IMAGING

          • General Features

            • Radiographic Findings

              • CT Findings

                • MR Findings

                  • Ultrasonographic Findings

                    • Nuclear Medicine Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Staging, Grading, & Classification

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Image Interpretation Pearls

                                        Selected References

                                        1. Song H et al: 18F-FDG PET/CT for evaluation of post-transplant lymphoproliferative disorder (PTLD). Semin Nucl Med. 51(4):392-403, 2021
                                        2. Dembowska-Bagińska B et al: Non-Hodgkin lymphoma after liver and kidney transplantation in children. Experience from one center. Adv Clin Exp Med. 29(2):197-202, 2020
                                        3. Hyun H et al: Post-transplant lymphoproliferative diseases in pediatric kidney allograft recipients with Epstein-Barr virus viremia. J Korean Med Sci. 34(30):e203, 2019
                                        4. Twist CJ et al: Treatment and outcomes in classic Hodgkin lymphoma post-transplant lymphoproliferative disorder in children. Pediatr Blood Cancer. 66(8):e27803, 2019
                                        5. White ML et al: Primary central nervous system post-transplant lymphoproliferative disorders: the spectrum of imaging appearances and differential. Insights Imaging. 10(1):46, 2019
                                        6. Venick RS: Long-term results of intestinal transplantation in children: survival after 10 years, intestinal function, quality of life. Curr Opin Organ Transplant. 23(2):219-23, 2018
                                        7. Absalon MJ et al: Post-transplant lymphoproliferative disorder after solid-organ transplant in children. Semin Pediatr Surg. 26(4):257-66, 2017
                                        8. Guerra-García P et al: Preliminary experience on the use of PET/CT in the management of pediatric post-transplant lymphoproliferative disorder. Pediatr Blood Cancer. 64(12), 2017
                                        9. Wistinghausen B et al: Post-transplant lymphoproliferative disease in pediatric solid organ transplant recipients. Pediatr Hematol Oncol. 30(6):520-31, 2013
                                        10. Borhani AA et al: Imaging of posttransplantation lymphoproliferative disorder after solid organ transplantation. Radiographics. 29(4):981-1000; discussion 1000-2, 2009
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Pathology

                                              • Clinical Issues

                                                TERMINOLOGY

                                                • Abbreviations

                                                  • Posttransplant lymphoproliferative disease (PTLD)
                                                • Definitions

                                                  • Spectrum of abnormal lymphoid proliferation in transplant patients

                                                IMAGING

                                                • General Features

                                                  • Radiographic Findings

                                                    • CT Findings

                                                      • MR Findings

                                                        • Ultrasonographic Findings

                                                          • Nuclear Medicine Findings

                                                            • Imaging Recommendations

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Staging, Grading, & Classification

                                                                    CLINICAL ISSUES

                                                                    • Presentation

                                                                      • Demographics

                                                                        • Natural History & Prognosis

                                                                          • Treatment

                                                                            DIAGNOSTIC CHECKLIST

                                                                            • Image Interpretation Pearls

                                                                              Selected References

                                                                              1. Song H et al: 18F-FDG PET/CT for evaluation of post-transplant lymphoproliferative disorder (PTLD). Semin Nucl Med. 51(4):392-403, 2021
                                                                              2. Dembowska-Bagińska B et al: Non-Hodgkin lymphoma after liver and kidney transplantation in children. Experience from one center. Adv Clin Exp Med. 29(2):197-202, 2020
                                                                              3. Hyun H et al: Post-transplant lymphoproliferative diseases in pediatric kidney allograft recipients with Epstein-Barr virus viremia. J Korean Med Sci. 34(30):e203, 2019
                                                                              4. Twist CJ et al: Treatment and outcomes in classic Hodgkin lymphoma post-transplant lymphoproliferative disorder in children. Pediatr Blood Cancer. 66(8):e27803, 2019
                                                                              5. White ML et al: Primary central nervous system post-transplant lymphoproliferative disorders: the spectrum of imaging appearances and differential. Insights Imaging. 10(1):46, 2019
                                                                              6. Venick RS: Long-term results of intestinal transplantation in children: survival after 10 years, intestinal function, quality of life. Curr Opin Organ Transplant. 23(2):219-23, 2018
                                                                              7. Absalon MJ et al: Post-transplant lymphoproliferative disorder after solid-organ transplant in children. Semin Pediatr Surg. 26(4):257-66, 2017
                                                                              8. Guerra-García P et al: Preliminary experience on the use of PET/CT in the management of pediatric post-transplant lymphoproliferative disorder. Pediatr Blood Cancer. 64(12), 2017
                                                                              9. Wistinghausen B et al: Post-transplant lymphoproliferative disease in pediatric solid organ transplant recipients. Pediatr Hematol Oncol. 30(6):520-31, 2013
                                                                              10. Borhani AA et al: Imaging of posttransplantation lymphoproliferative disorder after solid organ transplantation. Radiographics. 29(4):981-1000; discussion 1000-2, 2009