Juvenile head trauma syndrome: Diffuse brain or hemispheric swelling after single trivial injury
Due to rapidly progressive reactive hyperemia
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Ultrasonographic Findings
Angiographic Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Griemert EV et al: Deficiency of plasminogen activator inhibitor type 2 limits brain edema formation after traumatic brain injury. J Neurotrauma.36(14):2272-8, 2019
Hopp S et al: Alleviation of secondary brain injury, posttraumatic inflammation, and brain edema formation by inhibition of factor XIIa. J Neuroinflammation. 14(1):39, 2017
Mckee AC et al: The neuropathology of traumatic brain injury. Handb Clin Neurol. 127:45-66, 2015
Lu H et al: The apparent diffusion coefficient does not reflect cytotoxic edema on the uninjured side after traumatic brain injury. Neural Regen Res. 9(9):973-7, 2014
Paiva WS et al: Delayed unilateral traumatic brain swelling in a child. J Pediatr Neurosci. 9(2):169-71, 2014
Wu H et al: The diagnosis and surgical treatment of central brain herniations caused by traumatic bifrontal contusions. J Craniofac Surg. 25(6):2105-8, 2014
Bor-Seng-Shu E et al: Posttraumatic refractory intracranial hypertension and brain herniation syndrome: cerebral hemodynamic assessment before decompressive craniectomy. Biomed Res Int. 2013:750809, 2013
Ren W et al: Occludin and connexin 43 expression contribute to the pathogenesis of traumatic brain edema. Neural Regen Res. 8(29):2703-12, 2013
Squier W et al: The pathophysiology of brain swelling associated with subdural hemorrhage: the role of the trigeminovascular system. Childs Nerv Syst. 28(12):2005-15, 2012
Greve MW et al: Pathophysiology of traumatic brain injury. Mt Sinai J Med. 76(2):97-104, 2009
Tollard E et al: Experience of diffusion tensor imaging and 1H spectroscopy for outcome prediction in severe traumatic brain injury: Preliminary results. Crit Care Med. 37(4):1448-55, 2009
Galloway NR et al: Diffusion-weighted imaging improves outcome prediction in pediatric traumatic brain injury. J Neurotrauma. 25(10):1153-62, 2008
Juvenile head trauma syndrome: Diffuse brain or hemispheric swelling after single trivial injury
Due to rapidly progressive reactive hyperemia
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Ultrasonographic Findings
Angiographic Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Griemert EV et al: Deficiency of plasminogen activator inhibitor type 2 limits brain edema formation after traumatic brain injury. J Neurotrauma.36(14):2272-8, 2019
Hopp S et al: Alleviation of secondary brain injury, posttraumatic inflammation, and brain edema formation by inhibition of factor XIIa. J Neuroinflammation. 14(1):39, 2017
Mckee AC et al: The neuropathology of traumatic brain injury. Handb Clin Neurol. 127:45-66, 2015
Lu H et al: The apparent diffusion coefficient does not reflect cytotoxic edema on the uninjured side after traumatic brain injury. Neural Regen Res. 9(9):973-7, 2014
Paiva WS et al: Delayed unilateral traumatic brain swelling in a child. J Pediatr Neurosci. 9(2):169-71, 2014
Wu H et al: The diagnosis and surgical treatment of central brain herniations caused by traumatic bifrontal contusions. J Craniofac Surg. 25(6):2105-8, 2014
Bor-Seng-Shu E et al: Posttraumatic refractory intracranial hypertension and brain herniation syndrome: cerebral hemodynamic assessment before decompressive craniectomy. Biomed Res Int. 2013:750809, 2013
Ren W et al: Occludin and connexin 43 expression contribute to the pathogenesis of traumatic brain edema. Neural Regen Res. 8(29):2703-12, 2013
Squier W et al: The pathophysiology of brain swelling associated with subdural hemorrhage: the role of the trigeminovascular system. Childs Nerv Syst. 28(12):2005-15, 2012
Greve MW et al: Pathophysiology of traumatic brain injury. Mt Sinai J Med. 76(2):97-104, 2009
Tollard E et al: Experience of diffusion tensor imaging and 1H spectroscopy for outcome prediction in severe traumatic brain injury: Preliminary results. Crit Care Med. 37(4):1448-55, 2009
Galloway NR et al: Diffusion-weighted imaging improves outcome prediction in pediatric traumatic brain injury. J Neurotrauma. 25(10):1153-62, 2008
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