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Primary Brain Malignancy
Abdul-Rahman Abualruz, MD; Ashley F. Blurton, MD, MS; Paige Bennett, MD
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KEY FACTS

  • Imaging

    • Diagnostic Checklist

      TERMINOLOGY

      • Definitions

        • World Health Organization (WHO) brain tumor classification
          • Low-grade tumors
            • WHO grade I (noninvasive)
              • e.g., pilocytic astrocytoma
            • WHO grade II (partly invasive)
              • e.g., diffuse astrocytoma
          • High-grade tumors
            • WHO grade III (invasive)
              • e.g., anaplastic astrocytoma
            • WHO grade IV (highly invasive)
              • e.g., glioblastoma multiforme

      IMAGING

      • General Features

        • Nuclear Medicine Findings

          • Imaging Recommendations

            DIFFERENTIAL DIAGNOSIS

              PATHOLOGY

              • Staging, Grading, & Classification

                CLINICAL ISSUES

                • Presentation

                  • Demographics

                    • Natural History & Prognosis

                      • Treatment

                        DIAGNOSTIC CHECKLIST

                        • Consider

                          • Image Interpretation Pearls

                            Selected References

                            1. Kim MM et al: Non-invasive metabolic imaging of brain tumours in the era of precision medicine. Nat Rev Clin Oncol. 13(12):725-739, 2016
                            2. Fink JR et al: Multimodality brain tumor imaging: MR imaging, PET, and PET/MR imaging. J Nucl Med. 56(10):1554-61, 2015
                            3. Galldiks N et al: From the clinician's point of view - What is the status quo of positron emission tomography in patients with brain tumors? Neuro Oncol. 17(11):1434-44, 2015
                            4. Segtnan EA et al: ¹⁸F-fluorodeoxyglucose PET/computed tomography for primary brain tumors. PET Clin. 10(1):59-73, 2015
                            5. Wray R et al: (18)F-Flourodeoxy-glucose PET/computed tomography in brain tumors: Value to patient management and survival outcomes. PET Clin. 10(3):423-30, 2015
                            6. Demetriades AK et al: Applications of positron emission tomography in neuro-oncology: a clinical approach. Surgeon. 12(3):148-57, 2014
                            7. Suchorska B et al: PET imaging for brain tumor diagnostics. Curr Opin Neurol. 27(6):683-8, 2014
                            8. Kosaka N et al: 18F-FDG PET of common enhancing malignant brain tumors. AJR Am J Roentgenol. 190(6):W365-9, 2008
                            9. Chen W: Clinical applications of PET in brain tumors. J Nucl Med. 48(9):1468-81, 2007
                            10. Chen W et al: 18F-FDOPA PET imaging of brain tumors: comparison study with 18F-FDG PET and evaluation of diagnostic accuracy. J Nucl Med. 47(6):904-11, 2006
                            Related Anatomy
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                            Related Differential Diagnoses
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                            References
                            Tables

                            Tables

                            KEY FACTS

                            • Imaging

                              • Diagnostic Checklist

                                TERMINOLOGY

                                • Definitions

                                  • World Health Organization (WHO) brain tumor classification
                                    • Low-grade tumors
                                      • WHO grade I (noninvasive)
                                        • e.g., pilocytic astrocytoma
                                      • WHO grade II (partly invasive)
                                        • e.g., diffuse astrocytoma
                                    • High-grade tumors
                                      • WHO grade III (invasive)
                                        • e.g., anaplastic astrocytoma
                                      • WHO grade IV (highly invasive)
                                        • e.g., glioblastoma multiforme

                                IMAGING

                                • General Features

                                  • Nuclear Medicine Findings

                                    • Imaging Recommendations

                                      DIFFERENTIAL DIAGNOSIS

                                        PATHOLOGY

                                        • Staging, Grading, & Classification

                                          CLINICAL ISSUES

                                          • Presentation

                                            • Demographics

                                              • Natural History & Prognosis

                                                • Treatment

                                                  DIAGNOSTIC CHECKLIST

                                                  • Consider

                                                    • Image Interpretation Pearls

                                                      Selected References

                                                      1. Kim MM et al: Non-invasive metabolic imaging of brain tumours in the era of precision medicine. Nat Rev Clin Oncol. 13(12):725-739, 2016
                                                      2. Fink JR et al: Multimodality brain tumor imaging: MR imaging, PET, and PET/MR imaging. J Nucl Med. 56(10):1554-61, 2015
                                                      3. Galldiks N et al: From the clinician's point of view - What is the status quo of positron emission tomography in patients with brain tumors? Neuro Oncol. 17(11):1434-44, 2015
                                                      4. Segtnan EA et al: ¹⁸F-fluorodeoxyglucose PET/computed tomography for primary brain tumors. PET Clin. 10(1):59-73, 2015
                                                      5. Wray R et al: (18)F-Flourodeoxy-glucose PET/computed tomography in brain tumors: Value to patient management and survival outcomes. PET Clin. 10(3):423-30, 2015
                                                      6. Demetriades AK et al: Applications of positron emission tomography in neuro-oncology: a clinical approach. Surgeon. 12(3):148-57, 2014
                                                      7. Suchorska B et al: PET imaging for brain tumor diagnostics. Curr Opin Neurol. 27(6):683-8, 2014
                                                      8. Kosaka N et al: 18F-FDG PET of common enhancing malignant brain tumors. AJR Am J Roentgenol. 190(6):W365-9, 2008
                                                      9. Chen W: Clinical applications of PET in brain tumors. J Nucl Med. 48(9):1468-81, 2007
                                                      10. Chen W et al: 18F-FDOPA PET imaging of brain tumors: comparison study with 18F-FDG PET and evaluation of diagnostic accuracy. J Nucl Med. 47(6):904-11, 2006